Impurity analysis of retinoic acid samples

Gianna Allegrone; Elisabetta Brenna; Giovanni Fronza; Claudio Fuganti; Tommaso Giovenzana; Luciana Malpezzi; Enrico Barlocchi; Cesare Pellegatta

doi:10.1016/j.bmcl.2005.05.050

Impurity analysis of retinoic acid samples

Gianna Allegrone
, Elisabetta Brenna
, Giovanni Fronza
, Claudio Fuganti
, Tommaso Giovenzana
, Luciana Malpezzi
, Enrico Barlocchi
, Cesare Pellegatta

Department of Pharmaceutical Sciences

Research output: Contribution to journal › Article › peer-review

Abstract

The structure of an impurity contained in samples of all trans-retinoic acid was established by means of NMR and MS spectra, and confirmed by X-ray diffraction analysis. The chemical structure of the impurity 2 was found to be strictly correlated to the synthetic procedure employed for the preparation of the retinoic acid samples. Single crystal analysis allowed us to characterise the molecular conformation and the crystal structure of 2.

Original language	English
Pages (from-to)	3528-3531
Number of pages	4
Journal	Bioorganic and Medicinal Chemistry Letters
Volume	15
Issue number	15
DOIs	https://doi.org/10.1016/j.bmcl.2005.05.050
Publication status	Published - 1 Aug 2005

Keywords

Allylic oxidation
Impurity
Retinoic acid

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10.1016/j.bmcl.2005.05.050

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abstract = "The structure of an impurity contained in samples of all trans-retinoic acid was established by means of NMR and MS spectra, and confirmed by X-ray diffraction analysis. The chemical structure of the impurity 2 was found to be strictly correlated to the synthetic procedure employed for the preparation of the retinoic acid samples. Single crystal analysis allowed us to characterise the molecular conformation and the crystal structure of 2.",

keywords = "Allylic oxidation, Impurity, Retinoic acid",

author = "Gianna Allegrone and Elisabetta Brenna and Giovanni Fronza and Claudio Fuganti and Tommaso Giovenzana and Luciana Malpezzi and Enrico Barlocchi and Cesare Pellegatta",

year = "2005",

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doi = "10.1016/j.bmcl.2005.05.050",

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TY - JOUR

T1 - Impurity analysis of retinoic acid samples

AU - Allegrone, Gianna

AU - Brenna, Elisabetta

AU - Fronza, Giovanni

AU - Fuganti, Claudio

AU - Giovenzana, Tommaso

AU - Malpezzi, Luciana

AU - Barlocchi, Enrico

AU - Pellegatta, Cesare

PY - 2005/8/1

Y1 - 2005/8/1

N2 - The structure of an impurity contained in samples of all trans-retinoic acid was established by means of NMR and MS spectra, and confirmed by X-ray diffraction analysis. The chemical structure of the impurity 2 was found to be strictly correlated to the synthetic procedure employed for the preparation of the retinoic acid samples. Single crystal analysis allowed us to characterise the molecular conformation and the crystal structure of 2.

AB - The structure of an impurity contained in samples of all trans-retinoic acid was established by means of NMR and MS spectra, and confirmed by X-ray diffraction analysis. The chemical structure of the impurity 2 was found to be strictly correlated to the synthetic procedure employed for the preparation of the retinoic acid samples. Single crystal analysis allowed us to characterise the molecular conformation and the crystal structure of 2.

KW - Allylic oxidation

KW - Impurity

KW - Retinoic acid

UR - https://www.scopus.com/pages/publications/21744435062

U2 - 10.1016/j.bmcl.2005.05.050

DO - 10.1016/j.bmcl.2005.05.050

M3 - Article

SN - 0960-894X

VL - 15

SP - 3528

EP - 3531

JO - Bioorganic and Medicinal Chemistry Letters

JF - Bioorganic and Medicinal Chemistry Letters

IS - 15

ER -

Impurity analysis of retinoic acid samples

Abstract

Keywords

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