Improvement of water solubility and dissolution rate of ursodeoxycholic acid and chenodeoxycholic acid by complexation with natural and modified β-cyclodextrins

C. A. Ventura; S. Tirendi; G. Puglisi; E. Bousquet; L. Panza

doi:10.1016/S0378-5173(96)04821-1

Improvement of water solubility and dissolution rate of ursodeoxycholic acid and chenodeoxycholic acid by complexation with natural and modified β-cyclodextrins

C. A. Ventura
, S. Tirendi
, G. Puglisi
, E. Bousquet
, L. Panza

Research output: Contribution to journal › Article › peer-review

Abstract

The inclusion complexes of ursodeoxycholic and chenodeoxycholic acid with β-cyclodextrin, heptakis-(2,6-di-O-methyl)-β-cyclodextrin and soluble polymerized β-cyclodextrin were investigated in solution (¹H-MMR spectrometry) and solid state (FT-IR spectroscopy and differential scanning calorimetry). Stability constants were determined at pH 7.4 and different temperatures and consequently thermodynamic parameters were obtained. All cyclodextrins are able to increase water solubility of the bile acids, particularly polymerized β-cyclodextrin. All complexes show high dissolution rate at 37°C and pH 1.1 and in particular freeze-dried complexes.

Original language	English
Pages (from-to)	1-13
Number of pages	13
Journal	International Journal of Pharmaceutics
Volume	149
Issue number	1
DOIs	https://doi.org/10.1016/S0378-5173(96)04821-1
Publication status	Published - 14 Apr 1997
Externally published	Yes

Keywords

Blue acids
Characterization of the complexes
Dimethyl-β-cyclodextrin
Dissolution rate
Polymerized β-cyclodextrin
Solubility studies
β-Cyclodextrin

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10.1016/S0378-5173(96)04821-1

Cite this

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title = "Improvement of water solubility and dissolution rate of ursodeoxycholic acid and chenodeoxycholic acid by complexation with natural and modified β-cyclodextrins",

abstract = "The inclusion complexes of ursodeoxycholic and chenodeoxycholic acid with β-cyclodextrin, heptakis-(2,6-di-O-methyl)-β-cyclodextrin and soluble polymerized β-cyclodextrin were investigated in solution (1H-MMR spectrometry) and solid state (FT-IR spectroscopy and differential scanning calorimetry). Stability constants were determined at pH 7.4 and different temperatures and consequently thermodynamic parameters were obtained. All cyclodextrins are able to increase water solubility of the bile acids, particularly polymerized β-cyclodextrin. All complexes show high dissolution rate at 37°C and pH 1.1 and in particular freeze-dried complexes.",

keywords = "Blue acids, Characterization of the complexes, Dimethyl-β-cyclodextrin, Dissolution rate, Polymerized β-cyclodextrin, Solubility studies, β-Cyclodextrin",

author = "Ventura, \{C. A.\} and S. Tirendi and G. Puglisi and E. Bousquet and L. Panza",

year = "1997",

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doi = "10.1016/S0378-5173(96)04821-1",

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TY - JOUR

T1 - Improvement of water solubility and dissolution rate of ursodeoxycholic acid and chenodeoxycholic acid by complexation with natural and modified β-cyclodextrins

AU - Ventura, C. A.

AU - Tirendi, S.

AU - Puglisi, G.

AU - Bousquet, E.

AU - Panza, L.

PY - 1997/4/14

Y1 - 1997/4/14

N2 - The inclusion complexes of ursodeoxycholic and chenodeoxycholic acid with β-cyclodextrin, heptakis-(2,6-di-O-methyl)-β-cyclodextrin and soluble polymerized β-cyclodextrin were investigated in solution (1H-MMR spectrometry) and solid state (FT-IR spectroscopy and differential scanning calorimetry). Stability constants were determined at pH 7.4 and different temperatures and consequently thermodynamic parameters were obtained. All cyclodextrins are able to increase water solubility of the bile acids, particularly polymerized β-cyclodextrin. All complexes show high dissolution rate at 37°C and pH 1.1 and in particular freeze-dried complexes.

AB - The inclusion complexes of ursodeoxycholic and chenodeoxycholic acid with β-cyclodextrin, heptakis-(2,6-di-O-methyl)-β-cyclodextrin and soluble polymerized β-cyclodextrin were investigated in solution (1H-MMR spectrometry) and solid state (FT-IR spectroscopy and differential scanning calorimetry). Stability constants were determined at pH 7.4 and different temperatures and consequently thermodynamic parameters were obtained. All cyclodextrins are able to increase water solubility of the bile acids, particularly polymerized β-cyclodextrin. All complexes show high dissolution rate at 37°C and pH 1.1 and in particular freeze-dried complexes.

KW - Blue acids

KW - Characterization of the complexes

KW - Dimethyl-β-cyclodextrin

KW - Dissolution rate

KW - Polymerized β-cyclodextrin

KW - Solubility studies

KW - β-Cyclodextrin

UR - https://www.scopus.com/pages/publications/0030945137

U2 - 10.1016/S0378-5173(96)04821-1

DO - 10.1016/S0378-5173(96)04821-1

M3 - Article

SN - 0378-5173

VL - 149

SP - 1

EP - 13

JO - International Journal of Pharmaceutics

JF - International Journal of Pharmaceutics

IS - 1

ER -

Improvement of water solubility and dissolution rate of ursodeoxycholic acid and chenodeoxycholic acid by complexation with natural and modified β-cyclodextrins

Abstract

Keywords

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