Abstract
Aim: To perform a systematic review and meta-analysis of studies evaluating the influence of recipient angiotensin-converting enzyme insertion/deletion (ACE I/D) polymorphism on kidney function in renal transplant recipients. Materials & methods: A comprehensive search was performed through PubMed, Web of Knowledge and Cochrane databases up to December 2014. The methodological quality of identified studies was assessed using the MINORS criteria. Results: A total of 15 studies evaluating the role of recipient ACE I/D were included in the meta-analysis. In overall analyzes and subsequent subgroup and sensitivity analyzes, no evidence emerged of an effect of ACE I/D on serum creatinine levels, creatinine clearance or glomerular filtration rate. Conclusion: Although further investigation is still needed to determine the role of donor ACE genotype, recipient ACE I/D does not play a significant role on kidney function in renal transplant patients.
| Original language | English |
|---|---|
| Pages (from-to) | 1887-1902 |
| Number of pages | 16 |
| Journal | Pharmacogenomics |
| Volume | 16 |
| Issue number | 16 |
| DOIs | |
| Publication status | Published - Nov 2015 |
Keywords
- ACE
- allograft dysfunction
- meta-analysis
- polymorphisms
- renal transplantation
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