Immunological characterization of a rigid α-Tn mimetic on murine iNKT and human NK cells

Silvia Fallarini; Alvaro Brittoli; Michele Fiore; Grazia Lombardi; Olivier Renaudet; Barbara Richichi; Cristina Nativi

doi:10.1007/s10719-017-9775-6

Immunological characterization of a rigid α-Tn mimetic on murine iNKT and human NK cells

Silvia Fallarini
, Alvaro Brittoli
, Michele Fiore
, Grazia Lombardi
, Olivier Renaudet
, Barbara Richichi
, Cristina Nativi

Department of Pharmaceutical Sciences

Research output: Contribution to journal › Article › peer-review

Abstract

The ability of a rigid α-Tn mimetic (compound 1) to activate murine invariant natural killer T (iNKT) and human natural killer (NK) cells, two subsets of lymphocytes involved in cancer immunesurveillance, was investigated. For this purpose, the mimetic 1 was properly conjugated to a stearic acid containing glycerol-based phospholipid (compound 5) to be presented, in the context of the conserved non polymorphic major histocompatibility complex class I-like molecules (CD1d), to iNKT cells. On the contrary, the mimetic 1 was conjugated to a multivalent peptide-based scaffold (compound 6) to induce NK cell activation.

Original language	English
Pages (from-to)	553-562
Number of pages	10
Journal	Glycoconjugate Journal
Volume	34
Issue number	4
DOIs	https://doi.org/10.1007/s10719-017-9775-6
Publication status	Published - 1 Aug 2017

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

Keywords

Glycomimetic
Immunotherapy
Invariant natural killer T cells
Natural killer cells
α-Tn antigen

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10.1007/s10719-017-9775-6

Cite this

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title = "Immunological characterization of a rigid α-Tn mimetic on murine iNKT and human NK cells",

abstract = "The ability of a rigid α-Tn mimetic (compound 1) to activate murine invariant natural killer T (iNKT) and human natural killer (NK) cells, two subsets of lymphocytes involved in cancer immunesurveillance, was investigated. For this purpose, the mimetic 1 was properly conjugated to a stearic acid containing glycerol-based phospholipid (compound 5) to be presented, in the context of the conserved non polymorphic major histocompatibility complex class I-like molecules (CD1d), to iNKT cells. On the contrary, the mimetic 1 was conjugated to a multivalent peptide-based scaffold (compound 6) to induce NK cell activation.",

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T1 - Immunological characterization of a rigid α-Tn mimetic on murine iNKT and human NK cells

AU - Fallarini, Silvia

AU - Brittoli, Alvaro

AU - Fiore, Michele

AU - Lombardi, Grazia

AU - Renaudet, Olivier

AU - Richichi, Barbara

AU - Nativi, Cristina

PY - 2017/8/1

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N2 - The ability of a rigid α-Tn mimetic (compound 1) to activate murine invariant natural killer T (iNKT) and human natural killer (NK) cells, two subsets of lymphocytes involved in cancer immunesurveillance, was investigated. For this purpose, the mimetic 1 was properly conjugated to a stearic acid containing glycerol-based phospholipid (compound 5) to be presented, in the context of the conserved non polymorphic major histocompatibility complex class I-like molecules (CD1d), to iNKT cells. On the contrary, the mimetic 1 was conjugated to a multivalent peptide-based scaffold (compound 6) to induce NK cell activation.

AB - The ability of a rigid α-Tn mimetic (compound 1) to activate murine invariant natural killer T (iNKT) and human natural killer (NK) cells, two subsets of lymphocytes involved in cancer immunesurveillance, was investigated. For this purpose, the mimetic 1 was properly conjugated to a stearic acid containing glycerol-based phospholipid (compound 5) to be presented, in the context of the conserved non polymorphic major histocompatibility complex class I-like molecules (CD1d), to iNKT cells. On the contrary, the mimetic 1 was conjugated to a multivalent peptide-based scaffold (compound 6) to induce NK cell activation.

KW - Glycomimetic

KW - Immunotherapy

KW - Invariant natural killer T cells

KW - Natural killer cells

KW - α-Tn antigen

UR - https://www.scopus.com/pages/publications/85020119446

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M3 - Article

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JO - Glycoconjugate Journal

JF - Glycoconjugate Journal

IS - 4

ER -

Immunological characterization of a rigid α-Tn mimetic on murine iNKT and human NK cells

Abstract

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Keywords

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