Il costo dei ritardi nel trasferimento delle conoscenze dalla ricerca alla pratica clinica

[Machine translation] The delay in the transfer of knowledge from research to the clinic is a well-known problem that affects all fields of medicine with varying degrees of severity. However, in the case of substance dependence, this delay, and the consequences deriving from it, appear particularly serious. In fact, they affect early mortality, morbidity due to infectious diseases and the social costs related to disability and crimes. The poor administration of replacement treatments, the poor combination of pharmacological and psychosocial treatments, the low dosages, the failure to administer replacement treatments in prison and immediately after leaving prison, are some of the examples of the lack of transfer of knowledge from research to the clinic. A recent American study has shown that the risk of dying in the first two weeks after leaving prison is 12.7 times higher than that of the general population of the same age and that the risk of dying from an overdose is even 129 times higher, with an attributable proportion of 91%: 91% of these overdose deaths would probably have been prevented if they had received replacement treatment.