Identification of a Strigoterpenoid with Dual Nrf2 and Nf-Î°B Modulatory Activity

Federica Rogati; Estrella Millán; Giovanni Appendino; Alejandro Correa; Diego Caprioglio; Alberto Minassi; Eduardo Munoz

doi:10.1021/acsmedchemlett.8b00604

Identification of a Strigoterpenoid with Dual Nrf2 and Nf-Î°B Modulatory Activity

Federica Rogati
, Estrella Millán
, Giovanni Appendino
, Alejandro Correa
, Diego Caprioglio
, Alberto Minassi
, Eduardo Munoz

Department of Pharmaceutical Sciences

Research output: Contribution to journal › Article › peer-review

Abstract

The sesquiterpene-coumarin ether samarcandone provided a suitable framework to replace the apocarotenoid A-C ring system of strigol (1), replicating, after linking to a butenolide moiety, the activity of the natural phytohormone on Nrf2 and also showing potent NF-kB inhibitory activity, overall modulating two critical pathways of inflammation and cancer.

Original language	English
Pages (from-to)	606-610
Number of pages	5
Journal	ACS Medicinal Chemistry Letters
Volume	10
Issue number	4
DOIs	https://doi.org/10.1021/acsmedchemlett.8b00604
Publication status	Published - 11 Apr 2019

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

Keywords

NF-B
Nrf2
Strigolactones
terpenes

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10.1021/acsmedchemlett.8b00604

Cite this

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title = "Identification of a Strigoterpenoid with Dual Nrf2 and Nf-{\^I}°B Modulatory Activity",

abstract = "The sesquiterpene-coumarin ether samarcandone provided a suitable framework to replace the apocarotenoid A-C ring system of strigol (1), replicating, after linking to a butenolide moiety, the activity of the natural phytohormone on Nrf2 and also showing potent NF-kB inhibitory activity, overall modulating two critical pathways of inflammation and cancer.",

keywords = "NF-B, Nrf2, Strigolactones, terpenes",

author = "Federica Rogati and Estrella Mill{\'a}n and Giovanni Appendino and Alejandro Correa and Diego Caprioglio and Alberto Minassi and Eduardo Munoz",

note = "Publisher Copyright: {\textcopyright} 2019 American Chemical Society.",

year = "2019",

month = apr,

day = "11",

doi = "10.1021/acsmedchemlett.8b00604",

language = "English",

volume = "10",

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journal = "ACS Medicinal Chemistry Letters",

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TY - JOUR

T1 - Identification of a Strigoterpenoid with Dual Nrf2 and Nf-Î°B Modulatory Activity

AU - Rogati, Federica

AU - Millán, Estrella

AU - Appendino, Giovanni

AU - Correa, Alejandro

AU - Caprioglio, Diego

AU - Minassi, Alberto

AU - Munoz, Eduardo

PY - 2019/4/11

Y1 - 2019/4/11

N2 - The sesquiterpene-coumarin ether samarcandone provided a suitable framework to replace the apocarotenoid A-C ring system of strigol (1), replicating, after linking to a butenolide moiety, the activity of the natural phytohormone on Nrf2 and also showing potent NF-kB inhibitory activity, overall modulating two critical pathways of inflammation and cancer.

AB - The sesquiterpene-coumarin ether samarcandone provided a suitable framework to replace the apocarotenoid A-C ring system of strigol (1), replicating, after linking to a butenolide moiety, the activity of the natural phytohormone on Nrf2 and also showing potent NF-kB inhibitory activity, overall modulating two critical pathways of inflammation and cancer.

KW - NF-B

KW - Nrf2

KW - Strigolactones

KW - terpenes

UR - https://www.scopus.com/pages/publications/85060008254

U2 - 10.1021/acsmedchemlett.8b00604

DO - 10.1021/acsmedchemlett.8b00604

M3 - Article

SN - 1948-5875

VL - 10

SP - 606

EP - 610

JO - ACS Medicinal Chemistry Letters

JF - ACS Medicinal Chemistry Letters

IS - 4

ER -

Identification of a Strigoterpenoid with Dual Nrf2 and Nf-Î°B Modulatory Activity

Abstract

UN SDGs

Keywords

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