Hybrid inorganic (nonporous silica)/organic (alginate) core-shell platform for targeting a cisplatin-based Pt(IV) anticancer prodrug

Mauro Ravera; Elisabetta Gabano; Diego Bonzani; Ilaria Zanellato; Aldo Arrais; Simone Cantamessa; Marco Biggiogera; Domenico Osella

doi:10.1016/j.jinorgbio.2018.09.019

Hybrid inorganic (nonporous silica)/organic (alginate) core-shell platform for targeting a cisplatin-based Pt(IV) anticancer prodrug

Mauro Ravera
, Elisabetta Gabano
, Diego Bonzani
, Ilaria Zanellato
, Aldo Arrais
, Simone Cantamessa
, Marco Biggiogera
, Domenico Osella

Research output: Contribution to journal › Article › peer-review

Abstract

Nonporous silica nanoparticles with an external shell containing the 3‑aminopropyl arm (SiNP) were further decorated with alginic acid (SiNP-ALG) as a potential biocompatible delivery system for Pt antitumor agents. Such particles were coupled with the prodrug (OC‑6‑44)‑acetato(β‑alaninato)diamminedichloridoplatinum(IV), 1, through the formation of amide bonds between the pendant carboxylate groups on SiNP-ALG and the free amino group of the complex. Cytosol extracted from tumor cells was able to quickly and efficiently reduce the Pt(IV) prodrug, and produces the active metabolite cisplatin. SiNP-ALG-Pt conjugate was more active than both cisplatin and 1, due to its more efficient cell uptake, whereas the SiNP-ALG unplatinated nanoparticles were deprived of any nonspecific toxicity.

Original language	English
Pages (from-to)	185-191
Number of pages	7
Journal	Journal of Inorganic Biochemistry
Volume	189
DOIs	https://doi.org/10.1016/j.jinorgbio.2018.09.019
Publication status	Published - Dec 2018

Keywords

Alginic acid
Antiproliferative activity
Platinum(IV)
Silica nanoparticles

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10.1016/j.jinorgbio.2018.09.019

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@article{ad865c9d4daa4bfa9ebfe86d6fdf9689,

title = "Hybrid inorganic (nonporous silica)/organic (alginate) core-shell platform for targeting a cisplatin-based Pt(IV) anticancer prodrug",

abstract = "Nonporous silica nanoparticles with an external shell containing the 3‑aminopropyl arm (SiNP) were further decorated with alginic acid (SiNP-ALG) as a potential biocompatible delivery system for Pt antitumor agents. Such particles were coupled with the prodrug (OC‑6‑44)‑acetato(β‑alaninato)diamminedichloridoplatinum(IV), 1, through the formation of amide bonds between the pendant carboxylate groups on SiNP-ALG and the free amino group of the complex. Cytosol extracted from tumor cells was able to quickly and efficiently reduce the Pt(IV) prodrug, and produces the active metabolite cisplatin. SiNP-ALG-Pt conjugate was more active than both cisplatin and 1, due to its more efficient cell uptake, whereas the SiNP-ALG unplatinated nanoparticles were deprived of any nonspecific toxicity.",

keywords = "Alginic acid, Antiproliferative activity, Platinum(IV), Silica nanoparticles",

author = "Mauro Ravera and Elisabetta Gabano and Diego Bonzani and Ilaria Zanellato and Aldo Arrais and Simone Cantamessa and Marco Biggiogera and Domenico Osella",

note = "Publisher Copyright: {\textcopyright} 2018 Elsevier Inc.",

year = "2018",

month = dec,

doi = "10.1016/j.jinorgbio.2018.09.019",

language = "English",

volume = "189",

pages = "185--191",

journal = "Journal of Inorganic Biochemistry",

issn = "0162-0134",

publisher = "Elsevier Inc.",

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TY - JOUR

T1 - Hybrid inorganic (nonporous silica)/organic (alginate) core-shell platform for targeting a cisplatin-based Pt(IV) anticancer prodrug

AU - Ravera, Mauro

AU - Gabano, Elisabetta

AU - Bonzani, Diego

AU - Zanellato, Ilaria

AU - Arrais, Aldo

AU - Cantamessa, Simone

AU - Biggiogera, Marco

AU - Osella, Domenico

PY - 2018/12

Y1 - 2018/12

N2 - Nonporous silica nanoparticles with an external shell containing the 3‑aminopropyl arm (SiNP) were further decorated with alginic acid (SiNP-ALG) as a potential biocompatible delivery system for Pt antitumor agents. Such particles were coupled with the prodrug (OC‑6‑44)‑acetato(β‑alaninato)diamminedichloridoplatinum(IV), 1, through the formation of amide bonds between the pendant carboxylate groups on SiNP-ALG and the free amino group of the complex. Cytosol extracted from tumor cells was able to quickly and efficiently reduce the Pt(IV) prodrug, and produces the active metabolite cisplatin. SiNP-ALG-Pt conjugate was more active than both cisplatin and 1, due to its more efficient cell uptake, whereas the SiNP-ALG unplatinated nanoparticles were deprived of any nonspecific toxicity.

AB - Nonporous silica nanoparticles with an external shell containing the 3‑aminopropyl arm (SiNP) were further decorated with alginic acid (SiNP-ALG) as a potential biocompatible delivery system for Pt antitumor agents. Such particles were coupled with the prodrug (OC‑6‑44)‑acetato(β‑alaninato)diamminedichloridoplatinum(IV), 1, through the formation of amide bonds between the pendant carboxylate groups on SiNP-ALG and the free amino group of the complex. Cytosol extracted from tumor cells was able to quickly and efficiently reduce the Pt(IV) prodrug, and produces the active metabolite cisplatin. SiNP-ALG-Pt conjugate was more active than both cisplatin and 1, due to its more efficient cell uptake, whereas the SiNP-ALG unplatinated nanoparticles were deprived of any nonspecific toxicity.

KW - Alginic acid

KW - Antiproliferative activity

KW - Platinum(IV)

KW - Silica nanoparticles

UR - https://www.scopus.com/pages/publications/85054594264

U2 - 10.1016/j.jinorgbio.2018.09.019

DO - 10.1016/j.jinorgbio.2018.09.019

M3 - Article

SN - 0162-0134

VL - 189

SP - 185

EP - 191

JO - Journal of Inorganic Biochemistry

JF - Journal of Inorganic Biochemistry

ER -

Hybrid inorganic (nonporous silica)/organic (alginate) core-shell platform for targeting a cisplatin-based Pt(IV) anticancer prodrug

Abstract

Keywords

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