TY - JOUR
T1 - Human normal CD5+ B lymphocytes can be induced to differentiate to CD5- B lymphocytes with germinal center cell features
AU - Caligaris-Cappio, F.
AU - Riva, M.
AU - Tesio, L.
AU - Schena, M.
AU - Gaidano, G.
AU - Bergui, L.
PY - 1989
Y1 - 1989
N2 - A significant proportion of cord blood CD5+ B cells express the activation molecules CD23, CD25, and transferrin receptor; react with the cell-cycle-associated monoclonal antibody (MoAb) Ki67; can be induced to enter the S phase of cell cycle by interleukin-2 (IL-2), IL-4, or low-molecular-weight B-cell growth factor (lmw-BCGF) and, exposed to IL-1 and IL-2, acquire the features (sIgD-, CD5-, CD10+, CD38+) of B blasts proliferating in the germinal centers of secondary follicles. These findings indicate that CD5+ B cells are preactivated and, in the proper microenvironment, may give rise to CD5-B cells.
AB - A significant proportion of cord blood CD5+ B cells express the activation molecules CD23, CD25, and transferrin receptor; react with the cell-cycle-associated monoclonal antibody (MoAb) Ki67; can be induced to enter the S phase of cell cycle by interleukin-2 (IL-2), IL-4, or low-molecular-weight B-cell growth factor (lmw-BCGF) and, exposed to IL-1 and IL-2, acquire the features (sIgD-, CD5-, CD10+, CD38+) of B blasts proliferating in the germinal centers of secondary follicles. These findings indicate that CD5+ B cells are preactivated and, in the proper microenvironment, may give rise to CD5-B cells.
UR - http://www.scopus.com/inward/record.url?scp=0024551199&partnerID=8YFLogxK
U2 - 10.1182/blood.v73.5.1259.bloodjournal7351259
DO - 10.1182/blood.v73.5.1259.bloodjournal7351259
M3 - Article
SN - 0006-4971
VL - 73
SP - 1259
EP - 1263
JO - Blood
JF - Blood
IS - 5
ER -