Abstract
Granulocyte-macrophage colony-stimulating factor (GM-CSF) is a cytokine that stimulates the proliferation and differentiation of bone marrow progenitors. Moreover, the presence and activity of GM-CSF and its receptor (GM-CSF-r) has been documented on tissues and cell lines of a non-hemopoietic origin. In this paper we studied the expression and putative role of GM-CSF and GM-CSF-r in endometrial cancer. The modulation of GM-CSF-r alpha-chain upon progesterone treatment suggests a role for GM-CSF and its receptor in the pathogenesis and development of endometriial cancer.
| Original language | English |
|---|---|
| Pages (from-to) | 305-308 |
| Number of pages | 4 |
| Journal | European Journal of Gynaecological Oncology |
| Volume | 21 |
| Issue number | 3 |
| Publication status | Published - 2000 |
UN SDGs
This output contributes to the following UN Sustainable Development Goals (SDGs)
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SDG 3 Good Health and Well-being
Keywords
- Endometrial cancer
- GM-CSF receptor
- Progesterone
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