Abstract
Granulocyte-macrophage colony-stimulating factor (GM-CSF) is a cytokine that stimulates the proliferation and differentiation of bone marrow progenitors. Moreover, the presence and activity of GM-CSF and its receptor (GM-CSF-r) has been documented on tissues and cell lines of a non-hemopoietic origin. In this paper we studied the expression and putative role of GM-CSF and GM-CSF-r in endometrial cancer. The modulation of GM-CSF-r alpha-chain upon progesterone treatment suggests a role for GM-CSF and its receptor in the pathogenesis and development of endometriial cancer.
Original language | English |
---|---|
Pages (from-to) | 305-308 |
Number of pages | 4 |
Journal | European Journal of Gynaecological Oncology |
Volume | 21 |
Issue number | 3 |
Publication status | Published - 2000 |
Keywords
- Endometrial cancer
- GM-CSF receptor
- Progesterone