Hormonal modulation of GM-CSF receptor alpha-chain in in vitro models of endometrial cancer

G. Baj, A. Arnulfo, R. Boldorini, G. Nicosia, L. Villa, F. Malavasi, N. Surico, Deniz Yalman

Research output: Contribution to journalArticlepeer-review

Abstract

Granulocyte-macrophage colony-stimulating factor (GM-CSF) is a cytokine that stimulates the proliferation and differentiation of bone marrow progenitors. Moreover, the presence and activity of GM-CSF and its receptor (GM-CSF-r) has been documented on tissues and cell lines of a non-hemopoietic origin. In this paper we studied the expression and putative role of GM-CSF and GM-CSF-r in endometrial cancer. The modulation of GM-CSF-r alpha-chain upon progesterone treatment suggests a role for GM-CSF and its receptor in the pathogenesis and development of endometriial cancer.

Original languageEnglish
Pages (from-to)305-308
Number of pages4
JournalEuropean Journal of Gynaecological Oncology
Volume21
Issue number3
Publication statusPublished - 2000

Keywords

  • Endometrial cancer
  • GM-CSF receptor
  • Progesterone

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