Homologues and isomers of noladin ether, a putative novel endocannabinoid: Interaction with rat cannabinoid CB1 receptors

Giovanni Appendino; Alessia Ligresti; Alberto Minassi; Nives Daddario; Tiziana Bisogno; Vincenzo Di Marzo

doi:10.1016/S0960-894X(02)00839-9

Homologues and isomers of noladin ether, a putative novel endocannabinoid: Interaction with rat cannabinoid CB₁ receptors

Giovanni Appendino
, Alessia Ligresti
, Alberto Minassi
, Nives Daddario
, Tiziana Bisogno
, Vincenzo Di Marzo

Department of Pharmaceutical Sciences

Research output: Contribution to journal › Article › peer-review

Abstract

Two regioisomers and 13 analogues of the putative endocannabinoid noladin ether (2-arachidonyl glyceryl ether, 2-AGE, 1) were synthesized and tested for their interaction with CB₁ receptors in rat brain membranes. The results showed that a C-20 tetra-unsaturated moiety is necessary for high affinity, and that a series of alkyl glyceryl ethers of potential occurrence in brain tissues have less affinity than 2-AGE for CB₁ receptors.

Original language	English
Pages (from-to)	43-46
Number of pages	4
Journal	Bioorganic and Medicinal Chemistry Letters
Volume	13
Issue number	1
DOIs	https://doi.org/10.1016/S0960-894X(02)00839-9
Publication status	Published - 6 Jan 2003

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title = "Homologues and isomers of noladin ether, a putative novel endocannabinoid: Interaction with rat cannabinoid CB1 receptors",

abstract = "Two regioisomers and 13 analogues of the putative endocannabinoid noladin ether (2-arachidonyl glyceryl ether, 2-AGE, 1) were synthesized and tested for their interaction with CB1 receptors in rat brain membranes. The results showed that a C-20 tetra-unsaturated moiety is necessary for high affinity, and that a series of alkyl glyceryl ethers of potential occurrence in brain tissues have less affinity than 2-AGE for CB1 receptors.",

author = "Giovanni Appendino and Alessia Ligresti and Alberto Minassi and Nives Daddario and Tiziana Bisogno and \{Di Marzo\}, Vincenzo",

note = "Funding Information: We are grateful to Chemi (Cinisello Balsamo, MI, Italy) for a generous gift of d - and l -solketal, and to Giuseppe Guilla for his help in the synthesis of several glyceryl ethers. Support from MURST (grant 3933 to V.D.M.) is acknowledged.",

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doi = "10.1016/S0960-894X(02)00839-9",

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AU - Appendino, Giovanni

AU - Ligresti, Alessia

AU - Minassi, Alberto

AU - Daddario, Nives

AU - Bisogno, Tiziana

AU - Di Marzo, Vincenzo

N1 - Funding Information: We are grateful to Chemi (Cinisello Balsamo, MI, Italy) for a generous gift of d - and l -solketal, and to Giuseppe Guilla for his help in the synthesis of several glyceryl ethers. Support from MURST (grant 3933 to V.D.M.) is acknowledged.

PY - 2003/1/6

Y1 - 2003/1/6

N2 - Two regioisomers and 13 analogues of the putative endocannabinoid noladin ether (2-arachidonyl glyceryl ether, 2-AGE, 1) were synthesized and tested for their interaction with CB1 receptors in rat brain membranes. The results showed that a C-20 tetra-unsaturated moiety is necessary for high affinity, and that a series of alkyl glyceryl ethers of potential occurrence in brain tissues have less affinity than 2-AGE for CB1 receptors.

AB - Two regioisomers and 13 analogues of the putative endocannabinoid noladin ether (2-arachidonyl glyceryl ether, 2-AGE, 1) were synthesized and tested for their interaction with CB1 receptors in rat brain membranes. The results showed that a C-20 tetra-unsaturated moiety is necessary for high affinity, and that a series of alkyl glyceryl ethers of potential occurrence in brain tissues have less affinity than 2-AGE for CB1 receptors.

UR - https://www.scopus.com/pages/publications/1842864772

U2 - 10.1016/S0960-894X(02)00839-9

DO - 10.1016/S0960-894X(02)00839-9

M3 - Article

SN - 0960-894X

VL - 13

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JO - Bioorganic and Medicinal Chemistry Letters

JF - Bioorganic and Medicinal Chemistry Letters

IS - 1

ER -

Homologues and isomers of noladin ether, a putative novel endocannabinoid: Interaction with rat cannabinoid CB₁ receptors

Abstract

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