HLA supratypes in an Italian population

Sandra D'Alfonso; Nazario Cappello; Iolanda Borelli; Gina Mazzola; Daniela Peruccio; Mara Giordano; Isabella Cascino; Roberto Tosi; Patricia Momigliano Richiardi

doi:10.1007/BF00188614

HLA supratypes in an Italian population

Sandra D'Alfonso
, Nazario Cappello
, Iolanda Borelli
, Gina Mazzola
, Daniela Peruccio
, Mara Giordano
, Isabella Cascino
, Roberto Tosi
, Patricia Momigliano Richiardi

Research output: Contribution to journal › Article › peer-review

Abstract

A supratype analysis of a North Italian population was performed, using 16 polymorphisms in the HLA region spanning the HLA-A-DP segment. Fourteen supratypes were identified, mostly corresponding to those found in other Caucasiod populations. The degree of their conservation both within the B-DR/DQ region and in the regions telomeric and centromeric from HLA-A and DP was evaluated and linkage disequilibria among several DR and DP alleles were identified. Notably, the degree of association with DP increased when the DR marker was part of a conserved B-DR/DQ supratype. These data are relevant to the definition of the genetic structure of the population and to the prediction of probabilities of histocompatibility matching between unrelated individuals.

Original language	English
Pages (from-to)	114-120
Number of pages	7
Journal	Immunogenetics
Volume	39
Issue number	2
DOIs	https://doi.org/10.1007/BF00188614
Publication status	Published - Jan 1994
Externally published	Yes

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10.1007/BF00188614

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title = "HLA supratypes in an Italian population",

abstract = "A supratype analysis of a North Italian population was performed, using 16 polymorphisms in the HLA region spanning the HLA-A-DP segment. Fourteen supratypes were identified, mostly corresponding to those found in other Caucasiod populations. The degree of their conservation both within the B-DR/DQ region and in the regions telomeric and centromeric from HLA-A and DP was evaluated and linkage disequilibria among several DR and DP alleles were identified. Notably, the degree of association with DP increased when the DR marker was part of a conserved B-DR/DQ supratype. These data are relevant to the definition of the genetic structure of the population and to the prediction of probabilities of histocompatibility matching between unrelated individuals.",

author = "Sandra D'Alfonso and Nazario Cappello and Iolanda Borelli and Gina Mazzola and Daniela Peruccio and Mara Giordano and Isabella Cascino and Roberto Tosi and Richiardi, \{Patricia Momigliano\}",

year = "1994",

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doi = "10.1007/BF00188614",

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T1 - HLA supratypes in an Italian population

AU - D'Alfonso, Sandra

AU - Cappello, Nazario

AU - Borelli, Iolanda

AU - Mazzola, Gina

AU - Peruccio, Daniela

AU - Giordano, Mara

AU - Cascino, Isabella

AU - Tosi, Roberto

AU - Richiardi, Patricia Momigliano

PY - 1994/1

Y1 - 1994/1

N2 - A supratype analysis of a North Italian population was performed, using 16 polymorphisms in the HLA region spanning the HLA-A-DP segment. Fourteen supratypes were identified, mostly corresponding to those found in other Caucasiod populations. The degree of their conservation both within the B-DR/DQ region and in the regions telomeric and centromeric from HLA-A and DP was evaluated and linkage disequilibria among several DR and DP alleles were identified. Notably, the degree of association with DP increased when the DR marker was part of a conserved B-DR/DQ supratype. These data are relevant to the definition of the genetic structure of the population and to the prediction of probabilities of histocompatibility matching between unrelated individuals.

AB - A supratype analysis of a North Italian population was performed, using 16 polymorphisms in the HLA region spanning the HLA-A-DP segment. Fourteen supratypes were identified, mostly corresponding to those found in other Caucasiod populations. The degree of their conservation both within the B-DR/DQ region and in the regions telomeric and centromeric from HLA-A and DP was evaluated and linkage disequilibria among several DR and DP alleles were identified. Notably, the degree of association with DP increased when the DR marker was part of a conserved B-DR/DQ supratype. These data are relevant to the definition of the genetic structure of the population and to the prediction of probabilities of histocompatibility matching between unrelated individuals.

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M3 - Article

SN - 0093-7711

VL - 39

SP - 114

EP - 120

JO - Immunogenetics

JF - Immunogenetics

IS - 2

ER -

HLA supratypes in an Italian population

Abstract

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