Histamine release by free radicals: Paracetamol-induced histamine release from rat peritoneal mast cells after in vitro activation by monooxygenase

Emanuela Masini; Maura Lodovici; R. Fantozzi; Sandra Brunelleschi; A. Conti; P. F. Mannaioni

doi:10.1007/BF01987990

Histamine release by free radicals: Paracetamol-induced histamine release from rat peritoneal mast cells after in vitro activation by monooxygenase

Emanuela Masini, Maura Lodovici, R. Fantozzi, Sandra Brunelleschi, A. Conti, P. F. Mannaioni

Research output: Contribution to journal › Article › peer-review

Abstract

The incubation of paracetamol with isolated rat serosal mast cells evokes the release of histamine only in the presence of (S10) liver microsomes obtained from PCB or phenobarbital treated rats. The release of histamine was not accompanied by a leakage of lactate dehydrogenase and was blocked by the antioxidant α-tocopherol and by D-mannitol, an hydroxyl free radicals scavenger. The data are consistent with the metabolic oxidation of paracetamol in the generation of reactive intermediates capable of activating the sequential exocytosis.

Original language	English
Pages (from-to)	85-88
Number of pages	4
Journal	Agents and Actions
Volume	18
Issue number	1-2
DOIs	https://doi.org/10.1007/BF01987990
Publication status	Published - Apr 1986
Externally published	Yes

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title = "Histamine release by free radicals: Paracetamol-induced histamine release from rat peritoneal mast cells after in vitro activation by monooxygenase",

abstract = "The incubation of paracetamol with isolated rat serosal mast cells evokes the release of histamine only in the presence of (S10) liver microsomes obtained from PCB or phenobarbital treated rats. The release of histamine was not accompanied by a leakage of lactate dehydrogenase and was blocked by the antioxidant α-tocopherol and by D-mannitol, an hydroxyl free radicals scavenger. The data are consistent with the metabolic oxidation of paracetamol in the generation of reactive intermediates capable of activating the sequential exocytosis.",

author = "Emanuela Masini and Maura Lodovici and R. Fantozzi and Sandra Brunelleschi and A. Conti and Mannaioni, {P. F.}",

year = "1986",

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T2 - Paracetamol-induced histamine release from rat peritoneal mast cells after in vitro activation by monooxygenase

AU - Masini, Emanuela

AU - Lodovici, Maura

AU - Fantozzi, R.

AU - Brunelleschi, Sandra

AU - Conti, A.

AU - Mannaioni, P. F.

PY - 1986/4

Y1 - 1986/4

N2 - The incubation of paracetamol with isolated rat serosal mast cells evokes the release of histamine only in the presence of (S10) liver microsomes obtained from PCB or phenobarbital treated rats. The release of histamine was not accompanied by a leakage of lactate dehydrogenase and was blocked by the antioxidant α-tocopherol and by D-mannitol, an hydroxyl free radicals scavenger. The data are consistent with the metabolic oxidation of paracetamol in the generation of reactive intermediates capable of activating the sequential exocytosis.

AB - The incubation of paracetamol with isolated rat serosal mast cells evokes the release of histamine only in the presence of (S10) liver microsomes obtained from PCB or phenobarbital treated rats. The release of histamine was not accompanied by a leakage of lactate dehydrogenase and was blocked by the antioxidant α-tocopherol and by D-mannitol, an hydroxyl free radicals scavenger. The data are consistent with the metabolic oxidation of paracetamol in the generation of reactive intermediates capable of activating the sequential exocytosis.

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U2 - 10.1007/BF01987990

DO - 10.1007/BF01987990

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JO - Agents and Actions

JF - Agents and Actions

IS - 1-2

ER -

Histamine release by free radicals: Paracetamol-induced histamine release from rat peritoneal mast cells after in vitro activation by monooxygenase

Abstract

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