High incidence of spontaneous autoimmune thyroiditis in immunocompetent self-reactive human T cell receptor transgenic mice

Keyphrases

• Autoantigen 33%
• Autoimmune Thyroiditis 100%
• Autoimmunity 100%
• CD4+ 33%
• Genetically Modified T Cells 33%
• High Incidence 100%
• Humanized 33%
• Immunodominant Epitopes 33%
• Non-transgenic 33%
• Pathogenic Activity 33%
• RAG1 66%
• Regulatory Function 33%
• Regulatory T Cells 33%
• Self-reactivity 100%
• T Cell Receptor 100%
• T Cells 100%
• TCR Transgenic Mice 33%
• Thyroid Peroxidase Antibody (TPOAb) 33%
• Transgenic Mice 100%
• Transgenic Mouse Model 33%

Immunology and Microbiology

• Autoantigen 16%
• Autoimmune Thyroiditis 100%
• Autoimmunity 50%
• CD4 16%
• Epitope 16%
• Peroxidase 16%
• Recombination-Activating Gene 1 Knockout Mouse 16%
• Regulatory T Cell 16%
• T Cell 50%
• T Cell Receptor 100%
• Thyroid 16%
• Transgenic Mouse 100%
• Transgenic Organism 16%
• Transgenics 16%