GWAS meta-analysis of 16 852 women identifies new susceptibility locus for endometrial cancer

National Study Of Endometrial Cancer Genetics Group (NSECG); Australian National Endometrial Cancer Study Group (ANECS)

doi:10.1093/hmg/ddw092

GWAS meta-analysis of 16 852 women identifies new susceptibility locus for endometrial cancer

National Study Of Endometrial Cancer Genetics Group (NSECG)
, Australian National Endometrial Cancer Study Group (ANECS)

Research output: Contribution to journal › Article › peer-review

Abstract

Endometrial cancer is the most common gynecological malignancy in the developed world. Although there is evidence of genetic predisposition to the disease, most of the genetic risk remains unexplained. We present the meta-analysis results of four genome-wide association studies (4907 cases and 11 945 controls total) in women of European ancestry. We describe one new locus reaching genome-wide significance (P < 5 × 10 -8) at 6p22.3 (rs1740828; P = 2.29 × 10 -8, OR = 1.20), providing evidence of an additional region of interest for genetic susceptibility to endometrial cancer.

Original language	English
Pages (from-to)	2612-2620
Number of pages	9
Journal	Human Molecular Genetics
Volume	25
Issue number	12
DOIs	https://doi.org/10.1093/hmg/ddw092
Publication status	Published - 15 Jun 2016
Externally published	Yes

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10.1093/hmg/ddw092

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@article{f79a2b465ae34be8b8003c616f79e882,

title = "GWAS meta-analysis of 16 852 women identifies new susceptibility locus for endometrial cancer",

abstract = "Endometrial cancer is the most common gynecological malignancy in the developed world. Although there is evidence of genetic predisposition to the disease, most of the genetic risk remains unexplained. We present the meta-analysis results of four genome-wide association studies (4907 cases and 11 945 controls total) in women of European ancestry. We describe one new locus reaching genome-wide significance (P < 5 × 10 -8) at 6p22.3 (rs1740828; P = 2.29 × 10 -8, OR = 1.20), providing evidence of an additional region of interest for genetic susceptibility to endometrial cancer.",

author = "\{National Study Of Endometrial Cancer Genetics Group (NSECG)\} and \{Australian National Endometrial Cancer Study Group (ANECS)\} and Chen, \{Maxine M.\} and O'Mara, \{Tracy A.\} and Thompson, \{Deborah J.\} and Painter, \{Jodie N.\} and John Attia and Amanda Black and Louise Brinton and Stephen Chanock and Chu Chen and Cheng, \{Timothy Ht\} and Cook, \{Linda S.\} and Marta Crous-Bou and Jennifer Doherty and Friedenreich, \{Christine M.\} and Montserrat Garcia-Closas and Gaudet, \{Mia M.\} and Maggie Gorman and Christopher Haiman and Hankinson, \{Susan E.\} and Patricia Hartge and Henderson, \{Brian E.\} and Shirley Hodgson and Holliday, \{Elizabeth G.\} and Horn-Ross, \{Pamela L.\} and Hunter, \{David J.\} and \{Le Marchand\}, Loic and Xiaolin Liang and Jolanta Lissowska and Jirong Long and Lingeng Lu and Magliocco, \{Anthony M.\} and Lynn Martin and Mark McEvoy and Olson, \{Sara H.\} and Irene Orlow and Loreall Pooler and Jennifer Prescott and Radhai Rastogi and Rebbeck, \{Timothy R.\} and Harvey Risch and Carlotta Sacerdote and Frederick Schumacher and \{Wendy Setiawan\}, Veronica and Scott, \{Rodney J.\} and Xin Sheng and Shu, \{Xiao Ou\} and Constance Turman and \{Van Den Berg\}, David and Zhaoming Wang and Weiss, \{Noel S.\}",

year = "2016",

month = jun,

day = "15",

doi = "10.1093/hmg/ddw092",

language = "English",

volume = "25",

pages = "2612--2620",

journal = "Human Molecular Genetics",

issn = "0964-6906",

publisher = "Oxford University Press",

number = "12",

}

TY - JOUR

T1 - GWAS meta-analysis of 16 852 women identifies new susceptibility locus for endometrial cancer

AU - National Study Of Endometrial Cancer Genetics Group (NSECG)

AU - Australian National Endometrial Cancer Study Group (ANECS)

AU - Chen, Maxine M.

AU - O'Mara, Tracy A.

AU - Thompson, Deborah J.

AU - Painter, Jodie N.

AU - Attia, John

AU - Black, Amanda

AU - Brinton, Louise

AU - Chanock, Stephen

AU - Chen, Chu

AU - Cheng, Timothy Ht

AU - Cook, Linda S.

AU - Crous-Bou, Marta

AU - Doherty, Jennifer

AU - Friedenreich, Christine M.

AU - Garcia-Closas, Montserrat

AU - Gaudet, Mia M.

AU - Gorman, Maggie

AU - Haiman, Christopher

AU - Hankinson, Susan E.

AU - Hartge, Patricia

AU - Henderson, Brian E.

AU - Hodgson, Shirley

AU - Holliday, Elizabeth G.

AU - Horn-Ross, Pamela L.

AU - Hunter, David J.

AU - Le Marchand, Loic

AU - Liang, Xiaolin

AU - Lissowska, Jolanta

AU - Long, Jirong

AU - Lu, Lingeng

AU - Magliocco, Anthony M.

AU - Martin, Lynn

AU - McEvoy, Mark

AU - Olson, Sara H.

AU - Orlow, Irene

AU - Pooler, Loreall

AU - Prescott, Jennifer

AU - Rastogi, Radhai

AU - Rebbeck, Timothy R.

AU - Risch, Harvey

AU - Sacerdote, Carlotta

AU - Schumacher, Frederick

AU - Wendy Setiawan, Veronica

AU - Scott, Rodney J.

AU - Sheng, Xin

AU - Shu, Xiao Ou

AU - Turman, Constance

AU - Van Den Berg, David

AU - Wang, Zhaoming

AU - Weiss, Noel S.

PY - 2016/6/15

Y1 - 2016/6/15

N2 - Endometrial cancer is the most common gynecological malignancy in the developed world. Although there is evidence of genetic predisposition to the disease, most of the genetic risk remains unexplained. We present the meta-analysis results of four genome-wide association studies (4907 cases and 11 945 controls total) in women of European ancestry. We describe one new locus reaching genome-wide significance (P < 5 × 10 -8) at 6p22.3 (rs1740828; P = 2.29 × 10 -8, OR = 1.20), providing evidence of an additional region of interest for genetic susceptibility to endometrial cancer.

AB - Endometrial cancer is the most common gynecological malignancy in the developed world. Although there is evidence of genetic predisposition to the disease, most of the genetic risk remains unexplained. We present the meta-analysis results of four genome-wide association studies (4907 cases and 11 945 controls total) in women of European ancestry. We describe one new locus reaching genome-wide significance (P < 5 × 10 -8) at 6p22.3 (rs1740828; P = 2.29 × 10 -8, OR = 1.20), providing evidence of an additional region of interest for genetic susceptibility to endometrial cancer.

UR - https://www.scopus.com/pages/publications/85024098018

U2 - 10.1093/hmg/ddw092

DO - 10.1093/hmg/ddw092

M3 - Article

SN - 0964-6906

VL - 25

SP - 2612

EP - 2620

JO - Human Molecular Genetics

JF - Human Molecular Genetics

IS - 12

ER -

GWAS meta-analysis of 16 852 women identifies new susceptibility locus for endometrial cancer

Abstract

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