Gut microbiota diversity and T1DM onset: Preliminary data of a case-control study

Deborah Traversi; Ivana Rabbone; Maria Giovanna Ignaccolo; Giulia Carletto; Irene Racca; Camilla Vallini; Violetta Andriolo; Francesco Cadario; Silvia Savastio; Roberta Siliquini; Franco Cerutti

doi:10.1016/j.humic.2017.11.002

Gut microbiota diversity and T1DM onset: Preliminary data of a case-control study

Deborah Traversi
, Ivana Rabbone
, Maria Giovanna Ignaccolo
, Giulia Carletto
, Irene Racca
, Camilla Vallini
, Violetta Andriolo
, Francesco Cadario
, Silvia Savastio
, Roberta Siliquini
, Franco Cerutti

Research output: Contribution to journal › Article › peer-review

Abstract

Type-1 diabetes incidence is increasing during the last decades. Recently, a role of microbiota alteration is proposed as pre-diabetic and diabetic risk factor. A bicentric case-control study is in progress in Northern Italy. Here preliminary results are shown. The microbiome clusterization showed a division between cases and controls even if fingerprint profiles are heterogenic. Methanobrevibacter smithii is highly present only in few patients. The diversity index and the microorganism sequenced in cases and controls, seems to be quite dissimilar. The conclusive results could show a significant predictive value for the bio-indicators evaluated.

Original language	English
Pages (from-to)	11-13
Number of pages	3
Journal	Human Microbiome Journal
Volume	5-6
DOIs	https://doi.org/10.1016/j.humic.2017.11.002
Publication status	Published - Dec 2017
Externally published	Yes

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

Keywords

Children
Methanobrevibacter smithii
Microbiota
Type 1 diabetes mellitus
qRT-PCR

Access to Document

10.1016/j.humic.2017.11.002

Cite this

@article{4faf66608f4c409cb925ede82d91b7cb,

title = "Gut microbiota diversity and T1DM onset: Preliminary data of a case-control study",

abstract = "Type-1 diabetes incidence is increasing during the last decades. Recently, a role of microbiota alteration is proposed as pre-diabetic and diabetic risk factor. A bicentric case-control study is in progress in Northern Italy. Here preliminary results are shown. The microbiome clusterization showed a division between cases and controls even if fingerprint profiles are heterogenic. Methanobrevibacter smithii is highly present only in few patients. The diversity index and the microorganism sequenced in cases and controls, seems to be quite dissimilar. The conclusive results could show a significant predictive value for the bio-indicators evaluated.",

keywords = "Children, Methanobrevibacter smithii, Microbiota, Type 1 diabetes mellitus, qRT-PCR",

author = "Deborah Traversi and Ivana Rabbone and Ignaccolo, \{Maria Giovanna\} and Giulia Carletto and Irene Racca and Camilla Vallini and Violetta Andriolo and Francesco Cadario and Silvia Savastio and Roberta Siliquini and Franco Cerutti",

note = "Publisher Copyright: {\textcopyright} 2017 Elsevier Ltd. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).",

year = "2017",

month = dec,

doi = "10.1016/j.humic.2017.11.002",

language = "English",

volume = "5-6",

pages = "11--13",

journal = "Human Microbiome Journal",

issn = "2452-2317",

publisher = "Elsevier Ltd.",

}

TY - JOUR

T1 - Gut microbiota diversity and T1DM onset

T2 - Preliminary data of a case-control study

AU - Traversi, Deborah

AU - Rabbone, Ivana

AU - Ignaccolo, Maria Giovanna

AU - Carletto, Giulia

AU - Racca, Irene

AU - Vallini, Camilla

AU - Andriolo, Violetta

AU - Cadario, Francesco

AU - Savastio, Silvia

AU - Siliquini, Roberta

AU - Cerutti, Franco

PY - 2017/12

Y1 - 2017/12

N2 - Type-1 diabetes incidence is increasing during the last decades. Recently, a role of microbiota alteration is proposed as pre-diabetic and diabetic risk factor. A bicentric case-control study is in progress in Northern Italy. Here preliminary results are shown. The microbiome clusterization showed a division between cases and controls even if fingerprint profiles are heterogenic. Methanobrevibacter smithii is highly present only in few patients. The diversity index and the microorganism sequenced in cases and controls, seems to be quite dissimilar. The conclusive results could show a significant predictive value for the bio-indicators evaluated.

AB - Type-1 diabetes incidence is increasing during the last decades. Recently, a role of microbiota alteration is proposed as pre-diabetic and diabetic risk factor. A bicentric case-control study is in progress in Northern Italy. Here preliminary results are shown. The microbiome clusterization showed a division between cases and controls even if fingerprint profiles are heterogenic. Methanobrevibacter smithii is highly present only in few patients. The diversity index and the microorganism sequenced in cases and controls, seems to be quite dissimilar. The conclusive results could show a significant predictive value for the bio-indicators evaluated.

KW - Children

KW - Methanobrevibacter smithii

KW - Microbiota

KW - Type 1 diabetes mellitus

KW - qRT-PCR

UR - https://www.scopus.com/pages/publications/85034585712

U2 - 10.1016/j.humic.2017.11.002

DO - 10.1016/j.humic.2017.11.002

M3 - Article

SN - 2452-2317

VL - 5-6

SP - 11

EP - 13

JO - Human Microbiome Journal

JF - Human Microbiome Journal

ER -

Gut microbiota diversity and T1DM onset: Preliminary data of a case-control study

Abstract

UN SDGs

Keywords

Access to Document

Other files and links

Fingerprint

Cite this