‘Guess who’? An Italian multicentric study on pigmentation traits prevalence in endometriosis localizations

N. Salmeri; J. Ottolina; L. Bartiromo; M. Schimberni; C. Dolci; S. Ferrari; R. Villanacci; S. Arena; N. Berlanda; L. Buggio; A. Di Cello; E. Fuggetta; F. Maneschi; C. Massarotti; A. Mattei; F. Perelli; I. Pino; M. G. Porpora; D. Raimondo; V. Remorgida; R. Seracchioli; A. Ticino; P. Viganò; M. Vignali; F. Zullo; E. Zupi; L. Pagliardini; M. Candiani

doi:10.1016/j.ejogrb.2022.05.001

‘Guess who’? An Italian multicentric study on pigmentation traits prevalence in endometriosis localizations

N. Salmeri, J. Ottolina, L. Bartiromo, M. Schimberni, C. Dolci, S. Ferrari, R. Villanacci, S. Arena, N. Berlanda, L. Buggio, A. Di Cello, E. Fuggetta, F. Maneschi, C. Massarotti, A. Mattei, F. Perelli, I. Pino, M. G. Porpora, D. Raimondo, V. RemorgidaR. Seracchioli, A. Ticino, P. Viganò, M. Vignali, F. Zullo, E. Zupi, L. Pagliardini, M. Candiani

Research output: Contribution to journal › Article › peer-review

Abstract

Objectives: Previous evidence seems to support the more common presence of certain pigmentation types in women with endometriosis. The aim of this study was to assess the association of certain somatic phenotypes with specific localizations of the disease. The genetic makeup of those somatic traits may will help in better define the disease pathogenesis. Study design: Multicentric, retrospective study of women aged 18 to 45 with histologically confirmed endometriosis. 575 patients were recruited at eleven different Italian endometriosis clinics from March 2015 to January 2021. Data regarding clinical and surgical features were recorded following the self-administered endometriosis patient questionnaire and the surgical standard of reports approved by the World Endometriosis Research Foundation (WERF). Pigmentation types/somatic phenotypes frequencies among endometriosis localizations were reported. A logistic regression analysis was performed to determine somatic types independently associated with disease’ localizations. Results: Having green eyes increased by ∼4 folds (OR 3.7; 95% CI: 1.42–9.61; p = 0.007) the risk of having a ureteral nodule, whereas brown/black eyes decreased this risk (OR 0.34; 95% CI: 0.13–0.87; p = 0.025). Consistently, the combination of green eyes and blonde/light brown hairs increased the odds of ureteral endometriosis by more than 5 folds (OR 5.40; 95%CI: 2.02–14.49; p = 0.001), even after correction for anthropometric confounders (aOR 5.85; 95% CI: 2.13–16.09; p < 0.001). Conclusions: The association between endometriosis and pigmentary traits has been herein confirmed, with the novel finding of the possible predisposition of ureteral endometriosis in patients with green eyes and blonde/light brown hairs. Further investigation on the genetic makeup of somatic traits may provide new inroads also into the molecular aspects of endometriosis leading to a better understanding of this complex disease.

Original language	English
Pages (from-to)	5-12
Number of pages	8
Journal	European Journal of Obstetrics, Gynecology and Reproductive Biology
Volume	274
DOIs	https://doi.org/10.1016/j.ejogrb.2022.05.001
Publication status	Published - Jul 2022
Externally published	Yes

Keywords

Endometriosis
Pigmentation traits
Somatic phenotypes
Ureteral endometriosis

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10.1016/j.ejogrb.2022.05.001

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Salmeri, N., Ottolina, J., Bartiromo, L., Schimberni, M., Dolci, C., Ferrari, S., Villanacci, R., Arena, S., Berlanda, N., Buggio, L., Di Cello, A., Fuggetta, E., Maneschi, F., Massarotti, C., Mattei, A., Perelli, F., Pino, I., Porpora, M. G., Raimondo, D., ... Candiani, M. (2022). ‘Guess who’? An Italian multicentric study on pigmentation traits prevalence in endometriosis localizations. European Journal of Obstetrics, Gynecology and Reproductive Biology, 274, 5-12. https://doi.org/10.1016/j.ejogrb.2022.05.001

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title = "{\textquoteleft}Guess who{\textquoteright}? An Italian multicentric study on pigmentation traits prevalence in endometriosis localizations",

abstract = "Objectives: Previous evidence seems to support the more common presence of certain pigmentation types in women with endometriosis. The aim of this study was to assess the association of certain somatic phenotypes with specific localizations of the disease. The genetic makeup of those somatic traits may will help in better define the disease pathogenesis. Study design: Multicentric, retrospective study of women aged 18 to 45 with histologically confirmed endometriosis. 575 patients were recruited at eleven different Italian endometriosis clinics from March 2015 to January 2021. Data regarding clinical and surgical features were recorded following the self-administered endometriosis patient questionnaire and the surgical standard of reports approved by the World Endometriosis Research Foundation (WERF). Pigmentation types/somatic phenotypes frequencies among endometriosis localizations were reported. A logistic regression analysis was performed to determine somatic types independently associated with disease{\textquoteright} localizations. Results: Having green eyes increased by ∼4 folds (OR 3.7; 95% CI: 1.42–9.61; p = 0.007) the risk of having a ureteral nodule, whereas brown/black eyes decreased this risk (OR 0.34; 95% CI: 0.13–0.87; p = 0.025). Consistently, the combination of green eyes and blonde/light brown hairs increased the odds of ureteral endometriosis by more than 5 folds (OR 5.40; 95%CI: 2.02–14.49; p = 0.001), even after correction for anthropometric confounders (aOR 5.85; 95% CI: 2.13–16.09; p < 0.001). Conclusions: The association between endometriosis and pigmentary traits has been herein confirmed, with the novel finding of the possible predisposition of ureteral endometriosis in patients with green eyes and blonde/light brown hairs. Further investigation on the genetic makeup of somatic traits may provide new inroads also into the molecular aspects of endometriosis leading to a better understanding of this complex disease.",

keywords = "Endometriosis, Pigmentation traits, Somatic phenotypes, Ureteral endometriosis",

author = "N. Salmeri and J. Ottolina and L. Bartiromo and M. Schimberni and C. Dolci and S. Ferrari and R. Villanacci and S. Arena and N. Berlanda and L. Buggio and {Di Cello}, A. and E. Fuggetta and F. Maneschi and C. Massarotti and A. Mattei and F. Perelli and I. Pino and Porpora, {M. G.} and D. Raimondo and V. Remorgida and R. Seracchioli and A. Ticino and P. Vigan{\`o} and M. Vignali and F. Zullo and E. Zupi and L. Pagliardini and M. Candiani",

note = "Publisher Copyright: {\textcopyright} 2022 Elsevier B.V.",

year = "2022",

month = jul,

doi = "10.1016/j.ejogrb.2022.05.001",

language = "English",

volume = "274",

pages = "5--12",

journal = "European Journal of Obstetrics, Gynecology and Reproductive Biology",

issn = "0301-2115",

publisher = "Elsevier Ireland Ltd",

}

Salmeri, N, Ottolina, J, Bartiromo, L, Schimberni, M, Dolci, C, Ferrari, S, Villanacci, R, Arena, S, Berlanda, N, Buggio, L, Di Cello, A, Fuggetta, E, Maneschi, F, Massarotti, C, Mattei, A, Perelli, F, Pino, I, Porpora, MG, Raimondo, D, Remorgida, V, Seracchioli, R, Ticino, A, Viganò, P, Vignali, M, Zullo, F, Zupi, E, Pagliardini, L & Candiani, M 2022, '‘Guess who’? An Italian multicentric study on pigmentation traits prevalence in endometriosis localizations', European Journal of Obstetrics, Gynecology and Reproductive Biology, vol. 274, pp. 5-12. https://doi.org/10.1016/j.ejogrb.2022.05.001

TY - JOUR

T1 - ‘Guess who’? An Italian multicentric study on pigmentation traits prevalence in endometriosis localizations

AU - Salmeri, N.

AU - Ottolina, J.

AU - Bartiromo, L.

AU - Schimberni, M.

AU - Dolci, C.

AU - Ferrari, S.

AU - Villanacci, R.

AU - Arena, S.

AU - Berlanda, N.

AU - Buggio, L.

AU - Di Cello, A.

AU - Fuggetta, E.

AU - Maneschi, F.

AU - Massarotti, C.

AU - Mattei, A.

AU - Perelli, F.

AU - Pino, I.

AU - Porpora, M. G.

AU - Raimondo, D.

AU - Remorgida, V.

AU - Seracchioli, R.

AU - Ticino, A.

AU - Viganò, P.

AU - Vignali, M.

AU - Zullo, F.

AU - Zupi, E.

AU - Pagliardini, L.

AU - Candiani, M.

PY - 2022/7

Y1 - 2022/7

N2 - Objectives: Previous evidence seems to support the more common presence of certain pigmentation types in women with endometriosis. The aim of this study was to assess the association of certain somatic phenotypes with specific localizations of the disease. The genetic makeup of those somatic traits may will help in better define the disease pathogenesis. Study design: Multicentric, retrospective study of women aged 18 to 45 with histologically confirmed endometriosis. 575 patients were recruited at eleven different Italian endometriosis clinics from March 2015 to January 2021. Data regarding clinical and surgical features were recorded following the self-administered endometriosis patient questionnaire and the surgical standard of reports approved by the World Endometriosis Research Foundation (WERF). Pigmentation types/somatic phenotypes frequencies among endometriosis localizations were reported. A logistic regression analysis was performed to determine somatic types independently associated with disease’ localizations. Results: Having green eyes increased by ∼4 folds (OR 3.7; 95% CI: 1.42–9.61; p = 0.007) the risk of having a ureteral nodule, whereas brown/black eyes decreased this risk (OR 0.34; 95% CI: 0.13–0.87; p = 0.025). Consistently, the combination of green eyes and blonde/light brown hairs increased the odds of ureteral endometriosis by more than 5 folds (OR 5.40; 95%CI: 2.02–14.49; p = 0.001), even after correction for anthropometric confounders (aOR 5.85; 95% CI: 2.13–16.09; p < 0.001). Conclusions: The association between endometriosis and pigmentary traits has been herein confirmed, with the novel finding of the possible predisposition of ureteral endometriosis in patients with green eyes and blonde/light brown hairs. Further investigation on the genetic makeup of somatic traits may provide new inroads also into the molecular aspects of endometriosis leading to a better understanding of this complex disease.

AB - Objectives: Previous evidence seems to support the more common presence of certain pigmentation types in women with endometriosis. The aim of this study was to assess the association of certain somatic phenotypes with specific localizations of the disease. The genetic makeup of those somatic traits may will help in better define the disease pathogenesis. Study design: Multicentric, retrospective study of women aged 18 to 45 with histologically confirmed endometriosis. 575 patients were recruited at eleven different Italian endometriosis clinics from March 2015 to January 2021. Data regarding clinical and surgical features were recorded following the self-administered endometriosis patient questionnaire and the surgical standard of reports approved by the World Endometriosis Research Foundation (WERF). Pigmentation types/somatic phenotypes frequencies among endometriosis localizations were reported. A logistic regression analysis was performed to determine somatic types independently associated with disease’ localizations. Results: Having green eyes increased by ∼4 folds (OR 3.7; 95% CI: 1.42–9.61; p = 0.007) the risk of having a ureteral nodule, whereas brown/black eyes decreased this risk (OR 0.34; 95% CI: 0.13–0.87; p = 0.025). Consistently, the combination of green eyes and blonde/light brown hairs increased the odds of ureteral endometriosis by more than 5 folds (OR 5.40; 95%CI: 2.02–14.49; p = 0.001), even after correction for anthropometric confounders (aOR 5.85; 95% CI: 2.13–16.09; p < 0.001). Conclusions: The association between endometriosis and pigmentary traits has been herein confirmed, with the novel finding of the possible predisposition of ureteral endometriosis in patients with green eyes and blonde/light brown hairs. Further investigation on the genetic makeup of somatic traits may provide new inroads also into the molecular aspects of endometriosis leading to a better understanding of this complex disease.

KW - Endometriosis

KW - Pigmentation traits

KW - Somatic phenotypes

KW - Ureteral endometriosis

UR - http://www.scopus.com/inward/record.url?scp=85129745497&partnerID=8YFLogxK

U2 - 10.1016/j.ejogrb.2022.05.001

DO - 10.1016/j.ejogrb.2022.05.001

M3 - Article

SN - 0301-2115

VL - 274

SP - 5

EP - 12

JO - European Journal of Obstetrics, Gynecology and Reproductive Biology

JF - European Journal of Obstetrics, Gynecology and Reproductive Biology

ER -

‘Guess who’? An Italian multicentric study on pigmentation traits prevalence in endometriosis localizations

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Keywords

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