Abstract
In a program aimed at discovering novel protein kinase inhibitors, a convenient synthesis of 3,8-diaminoimidazo[1,2-a]pyrazines has been developed exploiting the isocyanide-based multicomponent Blackburn reaction, followed by a nucleophilic aromatic substitution with ammonia or primary and secondary amines. The potential of the reported scaffold is strengthened by the inhibition of STAT5-dependent transcription displayed by four of the synthesized compounds.
Original language | English |
---|---|
Pages (from-to) | 4144-4149 |
Number of pages | 6 |
Journal | Organic and Biomolecular Chemistry |
Volume | 9 |
Issue number | 11 |
DOIs | |
Publication status | Published - 7 Jun 2011 |