Genome-wide DNA analysis identifies recurrent imbalances predicting outcome in chronic lymphocytic leukaemia with 17p deletion

Francesco Forconi; Andrea Rinaldi; Ivo Kwee; Elisa Sozzi; Donatella Raspadori; Paola M.V. Rancoita; Marta Scandurra; Davide Rossi; Clara Deambrogi; Daniela Capello; Emanuele Zucca; Daniela Marconi; Riccardo Bomben; Valter Gattei; Francesco Lauria; Gianluca Gaidano; Francesco Bertoni

doi:10.1111/j.1365-2141.2008.07373.x

Genome-wide DNA analysis identifies recurrent imbalances predicting outcome in chronic lymphocytic leukaemia with 17p deletion

Francesco Forconi
, Andrea Rinaldi
, Ivo Kwee
, Elisa Sozzi
, Donatella Raspadori
, Paola M.V. Rancoita
, Marta Scandurra
, Davide Rossi
, Clara Deambrogi
, Daniela Capello
, Emanuele Zucca
, Daniela Marconi
, Riccardo Bomben
, Valter Gattei
, Francesco Lauria
, Gianluca Gaidano
, Francesco Bertoni

Department of Translational Medicine

Research output: Contribution to journal › Article › peer-review

Abstract

Deletion of 17p (TP53) identifies a rare subset of chronic lymphocytic leukaemia (17p- CLL) with aggressive behaviour. Genome-wide DNA-profiling was performed to investigate 18 patients with 17p- CLL. All cases had multiple copy-number (CN) changes. Among the several recurrent CN changes identified, 8q24.13-q24.1-gain (MYC), 8p-loss (TNFRSF10A/B, also known as TRAIL1/2) and 2p16.1-p14-gain (REL/BCL11A) appeared frequently represented. 8p-loss and 2p16.1-p14-gain also appeared clinically relevant and predicted significant shorter time from diagnosis to treatment (8p-loss) and overall survival (8p-loss and 2p16.1-p14-gain, P < 0.05). These observations document a highly unstable genome in 17p- CLL and suggest that additional genes outside the TP53 locus may be important for tumour behaviour.

Original language	English
Pages (from-to)	532-536
Number of pages	5
Journal	British Journal of Haematology
Volume	143
Issue number	4
DOIs	https://doi.org/10.1111/j.1365-2141.2008.07373.x
Publication status	Published - Nov 2008

Keywords

17p13 deletion
250K Affymetrix
Chronic lymphocytic leukaemia
Genome-wide DNA profile
Single nucleotide polymporphysms
TP53

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10.1111/j.1365-2141.2008.07373.x

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Forconi, F., Rinaldi, A., Kwee, I., Sozzi, E., Raspadori, D., Rancoita, P. M. V., Scandurra, M., Rossi, D., Deambrogi, C., Capello, D., Zucca, E., Marconi, D., Bomben, R., Gattei, V., Lauria, F., Gaidano, G., & Bertoni, F. (2008). Genome-wide DNA analysis identifies recurrent imbalances predicting outcome in chronic lymphocytic leukaemia with 17p deletion. British Journal of Haematology, 143(4), 532-536. https://doi.org/10.1111/j.1365-2141.2008.07373.x

@article{825bb01502c147c0bdf9e9d3f6d55111,

title = "Genome-wide DNA analysis identifies recurrent imbalances predicting outcome in chronic lymphocytic leukaemia with 17p deletion",

abstract = "Deletion of 17p (TP53) identifies a rare subset of chronic lymphocytic leukaemia (17p- CLL) with aggressive behaviour. Genome-wide DNA-profiling was performed to investigate 18 patients with 17p- CLL. All cases had multiple copy-number (CN) changes. Among the several recurrent CN changes identified, 8q24.13-q24.1-gain (MYC), 8p-loss (TNFRSF10A/B, also known as TRAIL1/2) and 2p16.1-p14-gain (REL/BCL11A) appeared frequently represented. 8p-loss and 2p16.1-p14-gain also appeared clinically relevant and predicted significant shorter time from diagnosis to treatment (8p-loss) and overall survival (8p-loss and 2p16.1-p14-gain, P < 0.05). These observations document a highly unstable genome in 17p- CLL and suggest that additional genes outside the TP53 locus may be important for tumour behaviour.",

keywords = "17p13 deletion, 250K Affymetrix, Chronic lymphocytic leukaemia, Genome-wide DNA profile, Single nucleotide polymporphysms, TP53",

author = "Francesco Forconi and Andrea Rinaldi and Ivo Kwee and Elisa Sozzi and Donatella Raspadori and Rancoita, \{Paola M.V.\} and Marta Scandurra and Davide Rossi and Clara Deambrogi and Daniela Capello and Emanuele Zucca and Daniela Marconi and Riccardo Bomben and Valter Gattei and Francesco Lauria and Gianluca Gaidano and Francesco Bertoni",

year = "2008",

month = nov,

doi = "10.1111/j.1365-2141.2008.07373.x",

language = "English",

volume = "143",

pages = "532--536",

journal = "British Journal of Haematology",

issn = "0007-1048",

publisher = "John Wiley and Sons Inc.",

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Forconi, F, Rinaldi, A, Kwee, I, Sozzi, E, Raspadori, D, Rancoita, PMV, Scandurra, M, Rossi, D, Deambrogi, C, Capello, D, Zucca, E, Marconi, D, Bomben, R, Gattei, V, Lauria, F, Gaidano, G & Bertoni, F 2008, 'Genome-wide DNA analysis identifies recurrent imbalances predicting outcome in chronic lymphocytic leukaemia with 17p deletion', British Journal of Haematology, vol. 143, no. 4, pp. 532-536. https://doi.org/10.1111/j.1365-2141.2008.07373.x

TY - JOUR

T1 - Genome-wide DNA analysis identifies recurrent imbalances predicting outcome in chronic lymphocytic leukaemia with 17p deletion

AU - Forconi, Francesco

AU - Rinaldi, Andrea

AU - Kwee, Ivo

AU - Sozzi, Elisa

AU - Raspadori, Donatella

AU - Rancoita, Paola M.V.

AU - Scandurra, Marta

AU - Rossi, Davide

AU - Deambrogi, Clara

AU - Capello, Daniela

AU - Zucca, Emanuele

AU - Marconi, Daniela

AU - Bomben, Riccardo

AU - Gattei, Valter

AU - Lauria, Francesco

AU - Gaidano, Gianluca

AU - Bertoni, Francesco

PY - 2008/11

Y1 - 2008/11

N2 - Deletion of 17p (TP53) identifies a rare subset of chronic lymphocytic leukaemia (17p- CLL) with aggressive behaviour. Genome-wide DNA-profiling was performed to investigate 18 patients with 17p- CLL. All cases had multiple copy-number (CN) changes. Among the several recurrent CN changes identified, 8q24.13-q24.1-gain (MYC), 8p-loss (TNFRSF10A/B, also known as TRAIL1/2) and 2p16.1-p14-gain (REL/BCL11A) appeared frequently represented. 8p-loss and 2p16.1-p14-gain also appeared clinically relevant and predicted significant shorter time from diagnosis to treatment (8p-loss) and overall survival (8p-loss and 2p16.1-p14-gain, P < 0.05). These observations document a highly unstable genome in 17p- CLL and suggest that additional genes outside the TP53 locus may be important for tumour behaviour.

AB - Deletion of 17p (TP53) identifies a rare subset of chronic lymphocytic leukaemia (17p- CLL) with aggressive behaviour. Genome-wide DNA-profiling was performed to investigate 18 patients with 17p- CLL. All cases had multiple copy-number (CN) changes. Among the several recurrent CN changes identified, 8q24.13-q24.1-gain (MYC), 8p-loss (TNFRSF10A/B, also known as TRAIL1/2) and 2p16.1-p14-gain (REL/BCL11A) appeared frequently represented. 8p-loss and 2p16.1-p14-gain also appeared clinically relevant and predicted significant shorter time from diagnosis to treatment (8p-loss) and overall survival (8p-loss and 2p16.1-p14-gain, P < 0.05). These observations document a highly unstable genome in 17p- CLL and suggest that additional genes outside the TP53 locus may be important for tumour behaviour.

KW - 17p13 deletion

KW - 250K Affymetrix

KW - Chronic lymphocytic leukaemia

KW - Genome-wide DNA profile

KW - Single nucleotide polymporphysms

KW - TP53

UR - https://www.scopus.com/pages/publications/54849430966

U2 - 10.1111/j.1365-2141.2008.07373.x

DO - 10.1111/j.1365-2141.2008.07373.x

M3 - Article

SN - 0007-1048

VL - 143

SP - 532

EP - 536

JO - British Journal of Haematology

JF - British Journal of Haematology

IS - 4

ER -

Genome-wide DNA analysis identifies recurrent imbalances predicting outcome in chronic lymphocytic leukaemia with 17p deletion

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Keywords

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