TY - JOUR
T1 - Genetic variation and autism
T2 - A field synopsis and systematic meta-analysis
AU - Lee, Jinhee
AU - Son, Min Ji
AU - Son, Chei Yun
AU - Jeong, Gwang Hun
AU - Lee, Keum Hwa
AU - Lee, Kwang Seob
AU - Ko, Younhee
AU - Kim, Jong Yeob
AU - Lee, Jun Young
AU - Radua, Joaquim
AU - Eisenhut, Michael
AU - Gressier, Florence
AU - Koyanagi, Ai
AU - Stubbs, Brendon
AU - Solmi, Marco
AU - Rais, Theodor B.
AU - Kronbichler, Andreas
AU - Dragioti, Elena
AU - Vasconcelos, Daniel Fernando Pereira
AU - da Silva, Felipe Rodolfo Pereira
AU - Tizaoui, Kalthoum
AU - Brunoni, André Russowsky
AU - Carvalho, Andre F.
AU - Cargnin, Sarah
AU - Terrazzino, Salvatore
AU - Stickley, Andrew
AU - Smith, Lee
AU - Thompson, Trevor
AU - Shin, Jae Il
AU - Fusar-Poli, Paolo
N1 - Publisher Copyright:
© 2020 by the authors. Licensee MDPI, Basel, Switzerland.
PY - 2020/10
Y1 - 2020/10
N2 - This study aimed to verify noteworthy findings between genetic risk factors and autism spectrum disorder (ASD) by employing the false positive report probability (FPRP) and the Bayesian false-discovery probability (BFDP). PubMed and the Genome-Wide Association Studies (GWAS) catalog were searched from inception to 1 August, 2019. We included meta-analyses on genetic factors of ASD of any study design. Overall, twenty-seven meta-analyses articles from literature searches, and four manually added articles from the GWAS catalog were re-analyzed. This showed that five of 31 comparisons for meta-analyses of observational studies, 40 out of 203 comparisons for the GWAS meta-analyses, and 18 out of 20 comparisons for the GWAS catalog, respectively, had noteworthy estimations under both Bayesian approaches. In this study, we found noteworthy genetic comparisons highly related to an increased risk of ASD. Multiple genetic comparisons were shown to be associated with ASD risk; however, genuine associations should be carefully verified and understood.
AB - This study aimed to verify noteworthy findings between genetic risk factors and autism spectrum disorder (ASD) by employing the false positive report probability (FPRP) and the Bayesian false-discovery probability (BFDP). PubMed and the Genome-Wide Association Studies (GWAS) catalog were searched from inception to 1 August, 2019. We included meta-analyses on genetic factors of ASD of any study design. Overall, twenty-seven meta-analyses articles from literature searches, and four manually added articles from the GWAS catalog were re-analyzed. This showed that five of 31 comparisons for meta-analyses of observational studies, 40 out of 203 comparisons for the GWAS meta-analyses, and 18 out of 20 comparisons for the GWAS catalog, respectively, had noteworthy estimations under both Bayesian approaches. In this study, we found noteworthy genetic comparisons highly related to an increased risk of ASD. Multiple genetic comparisons were shown to be associated with ASD risk; however, genuine associations should be carefully verified and understood.
KW - Autism spectrum disorder
KW - Bayesian false-discovery probability (BFDP)
KW - False positive report probability (FPRP)
KW - Genome-Wide Association Studies (GWAS)
KW - Meta-analysis
UR - https://www.scopus.com/pages/publications/85097364873
U2 - 10.3390/brainsci10100692
DO - 10.3390/brainsci10100692
M3 - Article
SN - 2076-3425
VL - 10
SP - 1
EP - 25
JO - Brain Sciences
JF - Brain Sciences
IS - 10
M1 - 692
ER -