Genetic Polymorphisms Affecting the Pharmacokinetics of Antiretroviral Drugs

Andrea CALCAGNO; JESSICA CUSATO; ANTONIO D'AVOLIO; Stefano BONORA

doi:10.1007/s40262-016-0456-6

Genetic Polymorphisms Affecting the Pharmacokinetics of Antiretroviral Drugs

Andrea CALCAGNO
, JESSICA CUSATO
, ANTONIO D'AVOLIO
, Stefano BONORA

Department of Translational Medicine

Research output: Contribution to journal › Article › peer-review

Abstract

Antiretroviral treatment is highly effective in enhancing HIV-positive patients' survival and quality of life. Despite an increased tolerability in recent years, a substantial amount of patients experience side effects. Antiretrovirals' efficacy and tolerability have been associated with plasma concentrations and single nucleotide polymorphisms in selected genes involved in drug disposition.

Original language	English
Pages (from-to)	355-369
Number of pages	15
Journal	Clinical Pharmacokinetics
Volume	56
Issue number	4
DOIs	https://doi.org/10.1007/s40262-016-0456-6
Publication status	Published - 2017

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This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

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10.1007/s40262-016-0456-6

https://hdl.handle.net/11579/216836

Cite this

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title = "Genetic Polymorphisms Affecting the Pharmacokinetics of Antiretroviral Drugs",

abstract = "Antiretroviral treatment is highly effective in enhancing HIV-positive patients' survival and quality of life. Despite an increased tolerability in recent years, a substantial amount of patients experience side effects. Antiretrovirals' efficacy and tolerability have been associated with plasma concentrations and single nucleotide polymorphisms in selected genes involved in drug disposition.",

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AU - BONORA, Stefano

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AB - Antiretroviral treatment is highly effective in enhancing HIV-positive patients' survival and quality of life. Despite an increased tolerability in recent years, a substantial amount of patients experience side effects. Antiretrovirals' efficacy and tolerability have been associated with plasma concentrations and single nucleotide polymorphisms in selected genes involved in drug disposition.

UR - https://iris.uniupo.it/handle/11579/216836

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SP - 355

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JO - Clinical Pharmacokinetics

JF - Clinical Pharmacokinetics

IS - 4

ER -

Genetic Polymorphisms Affecting the Pharmacokinetics of Antiretroviral Drugs

Abstract

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