Genetic pathways and histogenetic models of AIDS-related lymphomas

A. Carbone; A. Gloghini; D. Capello; G. Gaidano

doi:10.1016/S0959-8049(01)00119-8

Genetic pathways and histogenetic models of AIDS-related lymphomas

A. Carbone, A. Gloghini, D. Capello, G. Gaidano

Department of Translational Medicine

Research output: Contribution to journal › Article › peer-review

Abstract

Acquired immunodeficiency syndrome (AIDS)-related lymphomas consistently display a B-cell phenotype and are histogenetically related to germinal centre or post-germinal centre B cells in the overwhelming majority of cases. The pathogenesis of AIDS-related lymphoma is a multistep process involving factors provided by the host as well as alterations intrinsic to the tumour clone. The molecular pathways of viral infection and lesions of cancer-related genes associated with AIDS-related lymphomas vary substantially in different clinicopathological categories of the disease and highlight the marked degree of biological heterogeneity of these lymphomas.

Original language	English
Pages (from-to)	1270-1275
Number of pages	6
Journal	European Journal of Cancer
Volume	37
Issue number	10
DOIs	https://doi.org/10.1016/S0959-8049(01)00119-8
Publication status	Published - 2001

Keywords

AIDS
Histogenesis
Lymphomas
Pathogenesis

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1016/S0959-8049(01)00119-8

Cite this

@article{1e470c63283149fb9c726e6b6fe4487d,

title = "Genetic pathways and histogenetic models of AIDS-related lymphomas",

abstract = "Acquired immunodeficiency syndrome (AIDS)-related lymphomas consistently display a B-cell phenotype and are histogenetically related to germinal centre or post-germinal centre B cells in the overwhelming majority of cases. The pathogenesis of AIDS-related lymphoma is a multistep process involving factors provided by the host as well as alterations intrinsic to the tumour clone. The molecular pathways of viral infection and lesions of cancer-related genes associated with AIDS-related lymphomas vary substantially in different clinicopathological categories of the disease and highlight the marked degree of biological heterogeneity of these lymphomas.",

keywords = "AIDS, Histogenesis, Lymphomas, Pathogenesis",

author = "A. Carbone and A. Gloghini and D. Capello and G. Gaidano",

note = "Funding Information: Work by the authors described in this review has been supported by Istituto Superiore di Sanit{\`a}, III Programma Nazionale di Ricerca sull'AIDS 1999, Progetto Patologia, Clinica e Terapia dell'AIDS, Rome, Italy; Progetto di ricerca finalizzata “Nuovi marcatori molecolari e sierologici nella linfomagenesi virus-associata”, Ministero della Sanita', Rome, Italy, and by Associazione Italiana per la Ricerca sul Cancro (AIRC), Milan, Italy. The authors wish to thank particularly Ms M. Elettra Gislon for her precious secretarial assistance.",

year = "2001",

doi = "10.1016/S0959-8049(01)00119-8",

language = "English",

volume = "37",

pages = "1270--1275",

journal = "European Journal of Cancer",

issn = "0959-8049",

publisher = "Elsevier Ltd.",

number = "10",

}

TY - JOUR

T1 - Genetic pathways and histogenetic models of AIDS-related lymphomas

AU - Carbone, A.

AU - Gloghini, A.

AU - Capello, D.

AU - Gaidano, G.

N1 - Funding Information: Work by the authors described in this review has been supported by Istituto Superiore di Sanità, III Programma Nazionale di Ricerca sull'AIDS 1999, Progetto Patologia, Clinica e Terapia dell'AIDS, Rome, Italy; Progetto di ricerca finalizzata “Nuovi marcatori molecolari e sierologici nella linfomagenesi virus-associata”, Ministero della Sanita', Rome, Italy, and by Associazione Italiana per la Ricerca sul Cancro (AIRC), Milan, Italy. The authors wish to thank particularly Ms M. Elettra Gislon for her precious secretarial assistance.

PY - 2001

Y1 - 2001

N2 - Acquired immunodeficiency syndrome (AIDS)-related lymphomas consistently display a B-cell phenotype and are histogenetically related to germinal centre or post-germinal centre B cells in the overwhelming majority of cases. The pathogenesis of AIDS-related lymphoma is a multistep process involving factors provided by the host as well as alterations intrinsic to the tumour clone. The molecular pathways of viral infection and lesions of cancer-related genes associated with AIDS-related lymphomas vary substantially in different clinicopathological categories of the disease and highlight the marked degree of biological heterogeneity of these lymphomas.

AB - Acquired immunodeficiency syndrome (AIDS)-related lymphomas consistently display a B-cell phenotype and are histogenetically related to germinal centre or post-germinal centre B cells in the overwhelming majority of cases. The pathogenesis of AIDS-related lymphoma is a multistep process involving factors provided by the host as well as alterations intrinsic to the tumour clone. The molecular pathways of viral infection and lesions of cancer-related genes associated with AIDS-related lymphomas vary substantially in different clinicopathological categories of the disease and highlight the marked degree of biological heterogeneity of these lymphomas.

KW - AIDS

KW - Histogenesis

KW - Lymphomas

KW - Pathogenesis

UR - https://www.scopus.com/pages/publications/0034973084

U2 - 10.1016/S0959-8049(01)00119-8

DO - 10.1016/S0959-8049(01)00119-8

M3 - Article

SN - 0959-8049

VL - 37

SP - 1270

EP - 1275

JO - European Journal of Cancer

JF - European Journal of Cancer

IS - 10

ER -

Genetic pathways and histogenetic models of AIDS-related lymphomas

Abstract

Keywords

UN SDGs

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