Abstract
Acquired immunodeficiency syndrome (AIDS)-related lymphomas consistently display a B-cell phenotype and are histogenetically related to germinal centre or post-germinal centre B cells in the overwhelming majority of cases. The pathogenesis of AIDS-related lymphoma is a multistep process involving factors provided by the host as well as alterations intrinsic to the tumour clone. The molecular pathways of viral infection and lesions of cancer-related genes associated with AIDS-related lymphomas vary substantially in different clinicopathological categories of the disease and highlight the marked degree of biological heterogeneity of these lymphomas.
Original language | English |
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Pages (from-to) | 1270-1275 |
Number of pages | 6 |
Journal | European Journal of Cancer |
Volume | 37 |
Issue number | 10 |
DOIs | |
Publication status | Published - 2001 |
Keywords
- AIDS
- Histogenesis
- Lymphomas
- Pathogenesis