Genetic interaction of CTLA-4 with HLA-DR15 in multiple sclerosis patients

Mehdi Alizadeh; Marie Claude Babron; Brigitte Birebent; Fumihiko Matsuda; Erwann Quelvennec; Roland Liblau; Isabelle Cournu-Rebeix; Patricia Momigliano-Richiardi; Jorge Sequeiros; Jacqueline Yaouanq; Emmanuelle Genin; Alexandre Vasilescu; Héloise Bougerie; Maria Trojano; Berta Martins Silva; Patricia Maciel; Françoise Clerget-Darpoux; Michel Clanet; Gilles Edan; Bertrand Fontaine; Gilbert Semana

doi:10.1002/ana.10617

Genetic interaction of CTLA-4 with HLA-DR15 in multiple sclerosis patients

Mehdi Alizadeh
, Marie Claude Babron
, Brigitte Birebent
, Fumihiko Matsuda
, Erwann Quelvennec
, Roland Liblau
, Isabelle Cournu-Rebeix
, Patricia Momigliano-Richiardi
, Jorge Sequeiros
, Jacqueline Yaouanq
, Emmanuelle Genin
, Alexandre Vasilescu
, Héloise Bougerie
, Maria Trojano
, Berta Martins Silva
, Patricia Maciel
, Françoise Clerget-Darpoux
, Michel Clanet
, Gilles Edan
, Bertrand Fontaine

Gilbert Semana

Research output: Contribution to journal › Article › peer-review

Abstract

Multiple sclerosis is a chronic inflammatory disease of the central nervous system with a genetic component. Until now, the more consistent association with the disease is found with the major histocompatibility complex, especially HLA-DRB1*1501-DQB1*0602 haplotype. In this report, we demonstrate the interaction of Cytotoxic T Lymphocyte-associated antigen 4 (CTLA-4 [CD152]) gene with DRB1*15 haplotype in multiple sclerosis genetic susceptibility. Our data were obtained from two European independent family-based studies including 610 multiple sclerosis family trios.

Original language	English
Pages (from-to)	119-122
Number of pages	4
Journal	Annals of Neurology
Volume	54
Issue number	1
DOIs	https://doi.org/10.1002/ana.10617
Publication status	Published - 1 Jul 2003
Externally published	Yes

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Alizadeh, M., Babron, M. C., Birebent, B., Matsuda, F., Quelvennec, E., Liblau, R., Cournu-Rebeix, I., Momigliano-Richiardi, P., Sequeiros, J., Yaouanq, J., Genin, E., Vasilescu, A., Bougerie, H., Trojano, M., Silva, B. M., Maciel, P., Clerget-Darpoux, F., Clanet, M., Edan, G., ... Semana, G. (2003). Genetic interaction of CTLA-4 with HLA-DR15 in multiple sclerosis patients. Annals of Neurology, 54(1), 119-122. https://doi.org/10.1002/ana.10617

@article{58a728aeaf6540b5846dd0aa1ae62388,

title = "Genetic interaction of CTLA-4 with HLA-DR15 in multiple sclerosis patients",

abstract = "Multiple sclerosis is a chronic inflammatory disease of the central nervous system with a genetic component. Until now, the more consistent association with the disease is found with the major histocompatibility complex, especially HLA-DRB1*1501-DQB1*0602 haplotype. In this report, we demonstrate the interaction of Cytotoxic T Lymphocyte-associated antigen 4 (CTLA-4 [CD152]) gene with DRB1*15 haplotype in multiple sclerosis genetic susceptibility. Our data were obtained from two European independent family-based studies including 610 multiple sclerosis family trios.",

author = "Mehdi Alizadeh and Babron, \{Marie Claude\} and Brigitte Birebent and Fumihiko Matsuda and Erwann Quelvennec and Roland Liblau and Isabelle Cournu-Rebeix and Patricia Momigliano-Richiardi and Jorge Sequeiros and Jacqueline Yaouanq and Emmanuelle Genin and Alexandre Vasilescu and H{\'e}loise Bougerie and Maria Trojano and Silva, \{Berta Martins\} and Patricia Maciel and Fran{\c c}oise Clerget-Darpoux and Michel Clanet and Gilles Edan and Bertrand Fontaine and Gilbert Semana",

year = "2003",

month = jul,

day = "1",

doi = "10.1002/ana.10617",

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journal = "Annals of Neurology",

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Alizadeh, M, Babron, MC, Birebent, B, Matsuda, F, Quelvennec, E, Liblau, R, Cournu-Rebeix, I, Momigliano-Richiardi, P, Sequeiros, J, Yaouanq, J, Genin, E, Vasilescu, A, Bougerie, H, Trojano, M, Silva, BM, Maciel, P, Clerget-Darpoux, F, Clanet, M, Edan, G, Fontaine, B & Semana, G 2003, 'Genetic interaction of CTLA-4 with HLA-DR15 in multiple sclerosis patients', Annals of Neurology, vol. 54, no. 1, pp. 119-122. https://doi.org/10.1002/ana.10617

TY - JOUR

T1 - Genetic interaction of CTLA-4 with HLA-DR15 in multiple sclerosis patients

AU - Alizadeh, Mehdi

AU - Babron, Marie Claude

AU - Birebent, Brigitte

AU - Matsuda, Fumihiko

AU - Quelvennec, Erwann

AU - Liblau, Roland

AU - Cournu-Rebeix, Isabelle

AU - Momigliano-Richiardi, Patricia

AU - Sequeiros, Jorge

AU - Yaouanq, Jacqueline

AU - Genin, Emmanuelle

AU - Vasilescu, Alexandre

AU - Bougerie, Héloise

AU - Trojano, Maria

AU - Silva, Berta Martins

AU - Maciel, Patricia

AU - Clerget-Darpoux, Françoise

AU - Clanet, Michel

AU - Edan, Gilles

AU - Fontaine, Bertrand

AU - Semana, Gilbert

PY - 2003/7/1

Y1 - 2003/7/1

N2 - Multiple sclerosis is a chronic inflammatory disease of the central nervous system with a genetic component. Until now, the more consistent association with the disease is found with the major histocompatibility complex, especially HLA-DRB1*1501-DQB1*0602 haplotype. In this report, we demonstrate the interaction of Cytotoxic T Lymphocyte-associated antigen 4 (CTLA-4 [CD152]) gene with DRB1*15 haplotype in multiple sclerosis genetic susceptibility. Our data were obtained from two European independent family-based studies including 610 multiple sclerosis family trios.

AB - Multiple sclerosis is a chronic inflammatory disease of the central nervous system with a genetic component. Until now, the more consistent association with the disease is found with the major histocompatibility complex, especially HLA-DRB1*1501-DQB1*0602 haplotype. In this report, we demonstrate the interaction of Cytotoxic T Lymphocyte-associated antigen 4 (CTLA-4 [CD152]) gene with DRB1*15 haplotype in multiple sclerosis genetic susceptibility. Our data were obtained from two European independent family-based studies including 610 multiple sclerosis family trios.

UR - https://www.scopus.com/pages/publications/0037785378

U2 - 10.1002/ana.10617

DO - 10.1002/ana.10617

M3 - Article

SN - 0364-5134

VL - 54

SP - 119

EP - 122

JO - Annals of Neurology

JF - Annals of Neurology

IS - 1

ER -

Genetic interaction of CTLA-4 with HLA-DR15 in multiple sclerosis patients

Abstract

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