[Gd-AAZTA]-: A new structural entry for an improved generation of MRI contrast agents

Silvio Aime; Luisella Calabi; Camilla Cavallotti; Eliana Gianolio; Giovanni B. Giovenzana; Pietro Losi; Alessandro Maiocchi; Giovanni Palmisano; Massimo Sisti

doi:10.1021/ic0489692

[Gd-AAZTA]^-: A new structural entry for an improved generation of MRI contrast agents

Silvio Aime
, Luisella Calabi
, Camilla Cavallotti
, Eliana Gianolio
, Giovanni B. Giovenzana
, Pietro Losi
, Alessandro Maiocchi
, Giovanni Palmisano
, Massimo Sisti

Department of Pharmaceutical Sciences

Research output: Contribution to journal › Article › peer-review

Abstract

An innovative MRI contrast agent based on the unprecedented and easily obtained ligand AAZTA is described. The simple and straightforward synthesis of the ligand, together with the potentiometric and relaxometric behavior of the corresponding Gd(III) chelate, is reported. The complex [Gd(AAZTA)]^- shows outstanding magnetic properties connected with high thermodynamic stability in aqueous solution and a nearly complete inertness toward the influence of bidentate endogenous anions, placing this compound as one of the most promising candidates for the development of high performance MRI contrast agents.

Original language	English
Pages (from-to)	7588-7590
Number of pages	3
Journal	Inorganic Chemistry
Volume	43
Issue number	24
DOIs	https://doi.org/10.1021/ic0489692
Publication status	Published - 29 Nov 2004

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abstract = "An innovative MRI contrast agent based on the unprecedented and easily obtained ligand AAZTA is described. The simple and straightforward synthesis of the ligand, together with the potentiometric and relaxometric behavior of the corresponding Gd(III) chelate, is reported. The complex [Gd(AAZTA)]- shows outstanding magnetic properties connected with high thermodynamic stability in aqueous solution and a nearly complete inertness toward the influence of bidentate endogenous anions, placing this compound as one of the most promising candidates for the development of high performance MRI contrast agents.",

author = "Silvio Aime and Luisella Calabi and Camilla Cavallotti and Eliana Gianolio and Giovenzana, \{Giovanni B.\} and Pietro Losi and Alessandro Maiocchi and Giovanni Palmisano and Massimo Sisti",

year = "2004",

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doi = "10.1021/ic0489692",

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T2 - A new structural entry for an improved generation of MRI contrast agents

AU - Aime, Silvio

AU - Calabi, Luisella

AU - Cavallotti, Camilla

AU - Gianolio, Eliana

AU - Giovenzana, Giovanni B.

AU - Losi, Pietro

AU - Maiocchi, Alessandro

AU - Palmisano, Giovanni

AU - Sisti, Massimo

PY - 2004/11/29

Y1 - 2004/11/29

N2 - An innovative MRI contrast agent based on the unprecedented and easily obtained ligand AAZTA is described. The simple and straightforward synthesis of the ligand, together with the potentiometric and relaxometric behavior of the corresponding Gd(III) chelate, is reported. The complex [Gd(AAZTA)]- shows outstanding magnetic properties connected with high thermodynamic stability in aqueous solution and a nearly complete inertness toward the influence of bidentate endogenous anions, placing this compound as one of the most promising candidates for the development of high performance MRI contrast agents.

AB - An innovative MRI contrast agent based on the unprecedented and easily obtained ligand AAZTA is described. The simple and straightforward synthesis of the ligand, together with the potentiometric and relaxometric behavior of the corresponding Gd(III) chelate, is reported. The complex [Gd(AAZTA)]- shows outstanding magnetic properties connected with high thermodynamic stability in aqueous solution and a nearly complete inertness toward the influence of bidentate endogenous anions, placing this compound as one of the most promising candidates for the development of high performance MRI contrast agents.

UR - https://www.scopus.com/pages/publications/9444270383

U2 - 10.1021/ic0489692

DO - 10.1021/ic0489692

M3 - Article

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SP - 7588

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JO - Inorganic Chemistry

JF - Inorganic Chemistry

IS - 24

ER -

[Gd-AAZTA]^-: A new structural entry for an improved generation of MRI contrast agents

Abstract

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