Gangliosides attenuate NHDA receptor-mediated excitatory amino acid release in cultured cerebellar neurons

F. Nicoletti; B. Cavallaro; V. Bruno; M. Virgili; M. V. Catania; A. Contestabile; P. L. Canonico

doi:10.1016/0028-3908(89)90224-4

Gangliosides attenuate NHDA receptor-mediated excitatory amino acid release in cultured cerebellar neurons

F. Nicoletti, B. Cavallaro, V. Bruno, M. Virgili, M. V. Catania, A. Contestabile, P. L. Canonico

Research output: Contribution to journal › Article › peer-review

Abstract

Release of both D-[³H]aspartate and endogenous amino acids uas measured in primary cultures of cerebellargranule cells.Tuo hour-pretreatment with the glycosphingolipids, GM1 or GT1b, attenuatedthestimulation of excitatory amino acid release induced by depolarizing concentrations of K^- (50 mM). Gangliosides inhibited the phencyclidine (PCP)-sensitive component of depolarizationinduced release, i.e. the amplification of release that follous activation of NMDA receptorsby the endogenous glutamate.

Original language	English
Pages (from-to)	1283-1286
Number of pages	4
Journal	Neuropharmacology
Volume	28
Issue number	11
DOIs	https://doi.org/10.1016/0028-3908(89)90224-4
Publication status	Published - Nov 1989
Externally published	Yes

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10.1016/0028-3908(89)90224-4

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title = "Gangliosides attenuate NHDA receptor-mediated excitatory amino acid release in cultured cerebellar neurons",

abstract = "Release of both D-[3H]aspartate and endogenous amino acids uas measured in primary cultures of cerebellargranule cells.Tuo hour-pretreatment with the glycosphingolipids, GM1 or GT1b, attenuatedthestimulation of excitatory amino acid release induced by depolarizing concentrations of K- (50 mM). Gangliosides inhibited the phencyclidine (PCP)-sensitive component of depolarizationinduced release, i.e. the amplification of release that follous activation of NMDA receptorsby the endogenous glutamate.",

author = "F. Nicoletti and B. Cavallaro and V. Bruno and M. Virgili and Catania, \{M. V.\} and A. Contestabile and Canonico, \{P. L.\}",

year = "1989",

month = nov,

doi = "10.1016/0028-3908(89)90224-4",

language = "English",

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journal = "Neuropharmacology",

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T1 - Gangliosides attenuate NHDA receptor-mediated excitatory amino acid release in cultured cerebellar neurons

AU - Nicoletti, F.

AU - Cavallaro, B.

AU - Bruno, V.

AU - Virgili, M.

AU - Catania, M. V.

AU - Contestabile, A.

AU - Canonico, P. L.

PY - 1989/11

Y1 - 1989/11

N2 - Release of both D-[3H]aspartate and endogenous amino acids uas measured in primary cultures of cerebellargranule cells.Tuo hour-pretreatment with the glycosphingolipids, GM1 or GT1b, attenuatedthestimulation of excitatory amino acid release induced by depolarizing concentrations of K- (50 mM). Gangliosides inhibited the phencyclidine (PCP)-sensitive component of depolarizationinduced release, i.e. the amplification of release that follous activation of NMDA receptorsby the endogenous glutamate.

AB - Release of both D-[3H]aspartate and endogenous amino acids uas measured in primary cultures of cerebellargranule cells.Tuo hour-pretreatment with the glycosphingolipids, GM1 or GT1b, attenuatedthestimulation of excitatory amino acid release induced by depolarizing concentrations of K- (50 mM). Gangliosides inhibited the phencyclidine (PCP)-sensitive component of depolarizationinduced release, i.e. the amplification of release that follous activation of NMDA receptorsby the endogenous glutamate.

UR - https://www.scopus.com/pages/publications/0024420236

U2 - 10.1016/0028-3908(89)90224-4

DO - 10.1016/0028-3908(89)90224-4

M3 - Article

SN - 0028-3908

VL - 28

SP - 1283

EP - 1286

JO - Neuropharmacology

JF - Neuropharmacology

IS - 11

ER -

Gangliosides attenuate NHDA receptor-mediated excitatory amino acid release in cultured cerebellar neurons

Abstract

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