Abstract
Release of both D-[3H]aspartate and endogenous amino acids uas measured in primary cultures of cerebellargranule cells.Tuo hour-pretreatment with the glycosphingolipids, GM1 or GT1b, attenuatedthestimulation of excitatory amino acid release induced by depolarizing concentrations of K- (50 mM). Gangliosides inhibited the phencyclidine (PCP)-sensitive component of depolarizationinduced release, i.e. the amplification of release that follous activation of NMDA receptorsby the endogenous glutamate.
Original language | English |
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Pages (from-to) | 1283-1286 |
Number of pages | 4 |
Journal | Neuropharmacology |
Volume | 28 |
Issue number | 11 |
DOIs | |
Publication status | Published - Nov 1989 |
Externally published | Yes |