Gadolinium-loaded polychelating amphiphilic polymer as an enhanced MRI contrast agent for human multiple myeloma and non Hodgkin's lymphoma (human Burkitt's lymphoma)

Dorota Kozlowska; Swati Biswas; Eoin K. Fox; Bing Wu; Ferdia Bolster; Om Prakash Edupuganti; Vladimir Torchilin; Stephen Eustace; Mauro Botta; Richard O'Kennedy; Dermot F. Brougham

doi:10.1039/c3ra45400b

Gadolinium-loaded polychelating amphiphilic polymer as an enhanced MRI contrast agent for human multiple myeloma and non Hodgkin's lymphoma (human Burkitt's lymphoma)

Dorota Kozlowska
, Swati Biswas
, Eoin K. Fox
, Bing Wu
, Ferdia Bolster
, Om Prakash Edupuganti
, Vladimir Torchilin
, Stephen Eustace
, Mauro Botta
, Richard O'Kennedy
, Dermot F. Brougham

Department of Science and Technological Innovation

Research output: Contribution to journal › Article › peer-review

Abstract

Liposomes, loaded with gadolinium (Gd) ions using different membrane-incorporated chelating lipids and functionalized with monoclonal anti-CD138 (syndecan-1) antibody were prepared. Nuclear Magnetic Resonance Dispersion (NMRD) analysis showed that use of the polychelating amphiphilic polymer (PAP) increases both the Gd content and the spin-lattice relaxivity of the Gd-loaded-PAP-liposomes as compared to Gd-DTPA-BSA equivalents. The potential application of contrast syndecan-1- and Rituximab-liposomes, for application as a novel minimally invasive diagnostic agent for multiple myeloma and non Hodgkin's lymphoma was investigated.

Original language	English
Pages (from-to)	18007-18016
Number of pages	10
Journal	RSC Advances
Volume	4
Issue number	35
DOIs	https://doi.org/10.1039/c3ra45400b
Publication status	Published - 2014

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Kozlowska, D., Biswas, S., Fox, E. K., Wu, B., Bolster, F., Edupuganti, O. P., Torchilin, V., Eustace, S., Botta, M., O'Kennedy, R., & Brougham, D. F. (2014). Gadolinium-loaded polychelating amphiphilic polymer as an enhanced MRI contrast agent for human multiple myeloma and non Hodgkin's lymphoma (human Burkitt's lymphoma). RSC Advances, 4(35), 18007-18016. https://doi.org/10.1039/c3ra45400b

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title = "Gadolinium-loaded polychelating amphiphilic polymer as an enhanced MRI contrast agent for human multiple myeloma and non Hodgkin's lymphoma (human Burkitt's lymphoma)",

abstract = "Liposomes, loaded with gadolinium (Gd) ions using different membrane-incorporated chelating lipids and functionalized with monoclonal anti-CD138 (syndecan-1) antibody were prepared. Nuclear Magnetic Resonance Dispersion (NMRD) analysis showed that use of the polychelating amphiphilic polymer (PAP) increases both the Gd content and the spin-lattice relaxivity of the Gd-loaded-PAP-liposomes as compared to Gd-DTPA-BSA equivalents. The potential application of contrast syndecan-1- and Rituximab-liposomes, for application as a novel minimally invasive diagnostic agent for multiple myeloma and non Hodgkin's lymphoma was investigated.",

author = "Dorota Kozlowska and Swati Biswas and Fox, \{Eoin K.\} and Bing Wu and Ferdia Bolster and Edupuganti, \{Om Prakash\} and Vladimir Torchilin and Stephen Eustace and Mauro Botta and Richard O'Kennedy and Brougham, \{Dermot F.\}",

year = "2014",

doi = "10.1039/c3ra45400b",

language = "English",

volume = "4",

pages = "18007--18016",

journal = "RSC Advances",

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Kozlowska, D, Biswas, S, Fox, EK, Wu, B, Bolster, F, Edupuganti, OP, Torchilin, V, Eustace, S, Botta, M, O'Kennedy, R & Brougham, DF 2014, 'Gadolinium-loaded polychelating amphiphilic polymer as an enhanced MRI contrast agent for human multiple myeloma and non Hodgkin's lymphoma (human Burkitt's lymphoma)', RSC Advances, vol. 4, no. 35, pp. 18007-18016. https://doi.org/10.1039/c3ra45400b

TY - JOUR

T1 - Gadolinium-loaded polychelating amphiphilic polymer as an enhanced MRI contrast agent for human multiple myeloma and non Hodgkin's lymphoma (human Burkitt's lymphoma)

AU - Kozlowska, Dorota

AU - Biswas, Swati

AU - Fox, Eoin K.

AU - Wu, Bing

AU - Bolster, Ferdia

AU - Edupuganti, Om Prakash

AU - Torchilin, Vladimir

AU - Eustace, Stephen

AU - Botta, Mauro

AU - O'Kennedy, Richard

AU - Brougham, Dermot F.

PY - 2014

Y1 - 2014

N2 - Liposomes, loaded with gadolinium (Gd) ions using different membrane-incorporated chelating lipids and functionalized with monoclonal anti-CD138 (syndecan-1) antibody were prepared. Nuclear Magnetic Resonance Dispersion (NMRD) analysis showed that use of the polychelating amphiphilic polymer (PAP) increases both the Gd content and the spin-lattice relaxivity of the Gd-loaded-PAP-liposomes as compared to Gd-DTPA-BSA equivalents. The potential application of contrast syndecan-1- and Rituximab-liposomes, for application as a novel minimally invasive diagnostic agent for multiple myeloma and non Hodgkin's lymphoma was investigated.

AB - Liposomes, loaded with gadolinium (Gd) ions using different membrane-incorporated chelating lipids and functionalized with monoclonal anti-CD138 (syndecan-1) antibody were prepared. Nuclear Magnetic Resonance Dispersion (NMRD) analysis showed that use of the polychelating amphiphilic polymer (PAP) increases both the Gd content and the spin-lattice relaxivity of the Gd-loaded-PAP-liposomes as compared to Gd-DTPA-BSA equivalents. The potential application of contrast syndecan-1- and Rituximab-liposomes, for application as a novel minimally invasive diagnostic agent for multiple myeloma and non Hodgkin's lymphoma was investigated.

UR - https://www.scopus.com/pages/publications/84899566080

U2 - 10.1039/c3ra45400b

DO - 10.1039/c3ra45400b

M3 - Article

SN - 2046-2069

VL - 4

SP - 18007

EP - 18016

JO - RSC Advances

JF - RSC Advances

IS - 35

ER -

Gadolinium-loaded polychelating amphiphilic polymer as an enhanced MRI contrast agent for human multiple myeloma and non Hodgkin's lymphoma (human Burkitt's lymphoma)

Abstract

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