Abstract
The redox microenvironment within a cell graft can be considered as an indicator to assess whether the graft is metabolically active or hypoxic. We present a redox-responsive MRI probe based on porous silica microparticles whose surface has been decorated with a Gd-chelate through a disulphide bridge. Such microparticles are designed to be interspersed with therapeutic cells within a biocompatible hydrogel. The onset of reducing conditions within the hydrogel is paralleled by an increased clearance of Gd, that can be detected by MRI.
Original language | English |
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Pages (from-to) | 7716-7720 |
Number of pages | 5 |
Journal | Chemistry - A European Journal |
Volume | 22 |
Issue number | 23 |
DOIs | |
Publication status | Published - 1 Jun 2016 |
Keywords
- cellular imaging
- gadolinium
- magnetic resonance imaging
- redox-responsive
- silica microspheres