Gadolinium-Decorated Silica Microspheres as Redox-Responsive MRI Probes for Applications in Cell Therapy Follow-Up

Monica Muñoz Úbeda, Fabio Carniato, Valeria Catanzaro, Sergio Padovan, Cristina Grange, Stefano Porta, Carla Carrera, Lorenzo Tei, Giuseppe Digilio

Research output: Contribution to journalArticlepeer-review

Abstract

The redox microenvironment within a cell graft can be considered as an indicator to assess whether the graft is metabolically active or hypoxic. We present a redox-responsive MRI probe based on porous silica microparticles whose surface has been decorated with a Gd-chelate through a disulphide bridge. Such microparticles are designed to be interspersed with therapeutic cells within a biocompatible hydrogel. The onset of reducing conditions within the hydrogel is paralleled by an increased clearance of Gd, that can be detected by MRI.

Original languageEnglish
Pages (from-to)7716-7720
Number of pages5
JournalChemistry - A European Journal
Volume22
Issue number23
DOIs
Publication statusPublished - 1 Jun 2016

Keywords

  • cellular imaging
  • gadolinium
  • magnetic resonance imaging
  • redox-responsive
  • silica microspheres

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