From bone marrow to the arterial wall: The ongoing tale of endothelial progenitor cells

Antonio Maria Leone; Marco Valgimigli; Maria Benedetta Giannico; Vincenzo Zaccone; Matteo Perfetti; Domenico D'Amario; Antonio Giuseppe Rebuzzi; Filippo Crea

doi:10.1093/eurheartj/ehp078

From bone marrow to the arterial wall: The ongoing tale of endothelial progenitor cells

Antonio Maria Leone
, Marco Valgimigli
, Maria Benedetta Giannico
, Vincenzo Zaccone
, Matteo Perfetti
, Domenico D'Amario
, Antonio Giuseppe Rebuzzi
, Filippo Crea

Research output: Contribution to journal › Review article › peer-review

Abstract

Several physiological and pathophysiological stimuli or drugs modulate endothelial progenitor cell (EPC) mobilization. Moreover, levels of circulating EPCs predict cardiovascular risk and left ventricular remodelling after myocardial infarction. Nevertheless, our understanding in this field is complicated by lack of an unequivocal definition of EPCs, thus limiting their clinical applications. This review summarizes current knowledge and uncertainties on EPC characterization and mobilization in the attempt to define their role in the management of cardiovascular diseases.

Original language	English
Pages (from-to)	890-899
Number of pages	10
Journal	European Heart Journal
Volume	30
Issue number	8
DOIs	https://doi.org/10.1093/eurheartj/ehp078
Publication status	Published - Apr 2009
Externally published	Yes

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

Keywords

Acute myocardial infarction
Bone marrow-derived stem cells
Endothelial progenitor cells
Stem cell mobilization

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10.1093/eurheartj/ehp078

Cite this

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title = "From bone marrow to the arterial wall: The ongoing tale of endothelial progenitor cells",

abstract = "Several physiological and pathophysiological stimuli or drugs modulate endothelial progenitor cell (EPC) mobilization. Moreover, levels of circulating EPCs predict cardiovascular risk and left ventricular remodelling after myocardial infarction. Nevertheless, our understanding in this field is complicated by lack of an unequivocal definition of EPCs, thus limiting their clinical applications. This review summarizes current knowledge and uncertainties on EPC characterization and mobilization in the attempt to define their role in the management of cardiovascular diseases.",

keywords = "Acute myocardial infarction, Bone marrow-derived stem cells, Endothelial progenitor cells, Stem cell mobilization",

author = "Leone, \{Antonio Maria\} and Marco Valgimigli and Giannico, \{Maria Benedetta\} and Vincenzo Zaccone and Matteo Perfetti and Domenico D'Amario and Rebuzzi, \{Antonio Giuseppe\} and Filippo Crea",

note = "Funding Information: This study was supported by a grant from the Fondazione Cassa di Ris-parmio di Roma to UNICATT Cord Blood Bank of the Catholic University of the Sacred Heart of Rome.",

year = "2009",

month = apr,

doi = "10.1093/eurheartj/ehp078",

language = "English",

volume = "30",

pages = "890--899",

journal = "European Heart Journal",

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publisher = "Oxford University Press",

number = "8",

}

TY - JOUR

T1 - From bone marrow to the arterial wall

T2 - The ongoing tale of endothelial progenitor cells

AU - Leone, Antonio Maria

AU - Valgimigli, Marco

AU - Giannico, Maria Benedetta

AU - Zaccone, Vincenzo

AU - Perfetti, Matteo

AU - D'Amario, Domenico

AU - Rebuzzi, Antonio Giuseppe

AU - Crea, Filippo

N1 - Funding Information: This study was supported by a grant from the Fondazione Cassa di Ris-parmio di Roma to UNICATT Cord Blood Bank of the Catholic University of the Sacred Heart of Rome.

PY - 2009/4

Y1 - 2009/4

N2 - Several physiological and pathophysiological stimuli or drugs modulate endothelial progenitor cell (EPC) mobilization. Moreover, levels of circulating EPCs predict cardiovascular risk and left ventricular remodelling after myocardial infarction. Nevertheless, our understanding in this field is complicated by lack of an unequivocal definition of EPCs, thus limiting their clinical applications. This review summarizes current knowledge and uncertainties on EPC characterization and mobilization in the attempt to define their role in the management of cardiovascular diseases.

AB - Several physiological and pathophysiological stimuli or drugs modulate endothelial progenitor cell (EPC) mobilization. Moreover, levels of circulating EPCs predict cardiovascular risk and left ventricular remodelling after myocardial infarction. Nevertheless, our understanding in this field is complicated by lack of an unequivocal definition of EPCs, thus limiting their clinical applications. This review summarizes current knowledge and uncertainties on EPC characterization and mobilization in the attempt to define their role in the management of cardiovascular diseases.

KW - Acute myocardial infarction

KW - Bone marrow-derived stem cells

KW - Endothelial progenitor cells

KW - Stem cell mobilization

UR - https://www.scopus.com/pages/publications/65249187239

U2 - 10.1093/eurheartj/ehp078

DO - 10.1093/eurheartj/ehp078

M3 - Review article

SN - 0195-668X

VL - 30

SP - 890

EP - 899

JO - European Heart Journal

JF - European Heart Journal

IS - 8

ER -

From bone marrow to the arterial wall: The ongoing tale of endothelial progenitor cells

Abstract

UN SDGs

Keywords

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