Forensic mitochondrial DNA analysis in HIV-infected patients treated with nucleoside reverse transcriptase inhibitors

C. Robino; C. Colla; A. Biglino; M. Degioanni; S. Gino; C. Torre

doi:10.1016/j.fsigss.2009.08.023

Forensic mitochondrial DNA analysis in HIV-infected patients treated with nucleoside reverse transcriptase inhibitors

C. Robino
, C. Colla
, A. Biglino
, M. Degioanni
, S. Gino
, C. Torre

Research output: Contribution to journal › Article › peer-review

Abstract

Hypervariable regions HV1 and HV2 of the mitochondrial DNA control region were sequenced in pre-therapy (serum) and post-therapy (saliva, hair) biological samples collected from HIV-infected patients (n = 13) treated with nucleoside reverse transcriptase inhibitors (NRTIs). Occurrence of length/point heteroplasmic mutations as a consequence of treatment with NRTIs was evaluated. The observed rate of length heteroplasmy in the analyzed samples was consistent with values previously reported in untreated subjects, whereas no evidence of point heteroplasmy in post-treatment tissue samples was seen.

Original language	English
Pages (from-to)	501-502
Number of pages	2
Journal	Forensic Science International: Genetics Supplement Series
Volume	2
Issue number	1
DOIs	https://doi.org/10.1016/j.fsigss.2009.08.023
Publication status	Published - Jan 2009
Externally published	Yes

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

Keywords

Control region
HIV
Hair
Mitochondrial DNA
Reverse transcriptase inhibitors

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10.1016/j.fsigss.2009.08.023

Cite this

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title = "Forensic mitochondrial DNA analysis in HIV-infected patients treated with nucleoside reverse transcriptase inhibitors",

abstract = "Hypervariable regions HV1 and HV2 of the mitochondrial DNA control region were sequenced in pre-therapy (serum) and post-therapy (saliva, hair) biological samples collected from HIV-infected patients (n = 13) treated with nucleoside reverse transcriptase inhibitors (NRTIs). Occurrence of length/point heteroplasmic mutations as a consequence of treatment with NRTIs was evaluated. The observed rate of length heteroplasmy in the analyzed samples was consistent with values previously reported in untreated subjects, whereas no evidence of point heteroplasmy in post-treatment tissue samples was seen.",

keywords = "Control region, HIV, Hair, Mitochondrial DNA, Reverse transcriptase inhibitors",

author = "C. Robino and C. Colla and A. Biglino and M. Degioanni and S. Gino and C. Torre",

year = "2009",

month = jan,

doi = "10.1016/j.fsigss.2009.08.023",

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pages = "501--502",

journal = "Forensic Science International: Genetics Supplement Series",

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TY - JOUR

T1 - Forensic mitochondrial DNA analysis in HIV-infected patients treated with nucleoside reverse transcriptase inhibitors

AU - Robino, C.

AU - Colla, C.

AU - Biglino, A.

AU - Degioanni, M.

AU - Gino, S.

AU - Torre, C.

PY - 2009/1

Y1 - 2009/1

N2 - Hypervariable regions HV1 and HV2 of the mitochondrial DNA control region were sequenced in pre-therapy (serum) and post-therapy (saliva, hair) biological samples collected from HIV-infected patients (n = 13) treated with nucleoside reverse transcriptase inhibitors (NRTIs). Occurrence of length/point heteroplasmic mutations as a consequence of treatment with NRTIs was evaluated. The observed rate of length heteroplasmy in the analyzed samples was consistent with values previously reported in untreated subjects, whereas no evidence of point heteroplasmy in post-treatment tissue samples was seen.

AB - Hypervariable regions HV1 and HV2 of the mitochondrial DNA control region were sequenced in pre-therapy (serum) and post-therapy (saliva, hair) biological samples collected from HIV-infected patients (n = 13) treated with nucleoside reverse transcriptase inhibitors (NRTIs). Occurrence of length/point heteroplasmic mutations as a consequence of treatment with NRTIs was evaluated. The observed rate of length heteroplasmy in the analyzed samples was consistent with values previously reported in untreated subjects, whereas no evidence of point heteroplasmy in post-treatment tissue samples was seen.

KW - Control region

KW - HIV

KW - Hair

KW - Mitochondrial DNA

KW - Reverse transcriptase inhibitors

UR - https://www.scopus.com/pages/publications/70649112203

U2 - 10.1016/j.fsigss.2009.08.023

DO - 10.1016/j.fsigss.2009.08.023

M3 - Article

AN - SCOPUS:70649112203

SN - 1875-1768

VL - 2

SP - 501

EP - 502

JO - Forensic Science International: Genetics Supplement Series

JF - Forensic Science International: Genetics Supplement Series

IS - 1

ER -

Forensic mitochondrial DNA analysis in HIV-infected patients treated with nucleoside reverse transcriptase inhibitors

Abstract

UN SDGs

Keywords

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