FMLP-activated neutrophils evoke histamine release from mast cells

R. Fantozzi; S. Brunelleschi; A. Rubino; S. Tarli; E. Masini; P. F. Mannaioni

doi:10.1007/BF01988009

FMLP-activated neutrophils evoke histamine release from mast cells

R. Fantozzi
, S. Brunelleschi
, A. Rubino
, S. Tarli
, E. Masini
, P. F. Mannaioni

Research output: Contribution to journal › Article › peer-review

Abstract

Human neutrophils, having been activated by the chemotactic peptide N-formylmethionyl-leucyl-phenylalanine (FMLP), evoke histamine release from rat serosal mast cells. The release is dependent on FMLP concentration and it can be inhibited by disodium cromoglycate and by a flavonoid, silymarin, which displays free radical scavenging properties. Silymarin inhibition of neutrophil-mediated histamine release is dose-dependent. These results further stress the concept of a neutrophil-mast cell interaction, which may be involved in inflammatory processes.

Original language	English
Pages (from-to)	155-158
Number of pages	4
Journal	Agents and Actions
Volume	18
Issue number	1-2
DOIs	https://doi.org/10.1007/BF01988009
Publication status	Published - Apr 1986
Externally published	Yes

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title = "FMLP-activated neutrophils evoke histamine release from mast cells",

abstract = "Human neutrophils, having been activated by the chemotactic peptide N-formylmethionyl-leucyl-phenylalanine (FMLP), evoke histamine release from rat serosal mast cells. The release is dependent on FMLP concentration and it can be inhibited by disodium cromoglycate and by a flavonoid, silymarin, which displays free radical scavenging properties. Silymarin inhibition of neutrophil-mediated histamine release is dose-dependent. These results further stress the concept of a neutrophil-mast cell interaction, which may be involved in inflammatory processes.",

author = "R. Fantozzi and S. Brunelleschi and A. Rubino and S. Tarli and E. Masini and Mannaioni, \{P. F.\}",

year = "1986",

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doi = "10.1007/BF01988009",

language = "English",

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TY - JOUR

T1 - FMLP-activated neutrophils evoke histamine release from mast cells

AU - Fantozzi, R.

AU - Brunelleschi, S.

AU - Rubino, A.

AU - Tarli, S.

AU - Masini, E.

AU - Mannaioni, P. F.

PY - 1986/4

Y1 - 1986/4

N2 - Human neutrophils, having been activated by the chemotactic peptide N-formylmethionyl-leucyl-phenylalanine (FMLP), evoke histamine release from rat serosal mast cells. The release is dependent on FMLP concentration and it can be inhibited by disodium cromoglycate and by a flavonoid, silymarin, which displays free radical scavenging properties. Silymarin inhibition of neutrophil-mediated histamine release is dose-dependent. These results further stress the concept of a neutrophil-mast cell interaction, which may be involved in inflammatory processes.

AB - Human neutrophils, having been activated by the chemotactic peptide N-formylmethionyl-leucyl-phenylalanine (FMLP), evoke histamine release from rat serosal mast cells. The release is dependent on FMLP concentration and it can be inhibited by disodium cromoglycate and by a flavonoid, silymarin, which displays free radical scavenging properties. Silymarin inhibition of neutrophil-mediated histamine release is dose-dependent. These results further stress the concept of a neutrophil-mast cell interaction, which may be involved in inflammatory processes.

UR - https://www.scopus.com/pages/publications/0022611095

U2 - 10.1007/BF01988009

DO - 10.1007/BF01988009

M3 - Article

SN - 0065-4299

VL - 18

SP - 155

EP - 158

JO - Agents and Actions

JF - Agents and Actions

IS - 1-2

ER -

FMLP-activated neutrophils evoke histamine release from mast cells

Abstract

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