Flavonoid oligoglycosides from Ophioglossum vulgatum L. Having wound healing properties

Marco Clericuzio; Stefano Tinello; Bruno Burlando; Elia Ranzato; Simona Martinotti; Laura Cornara; Arianna La Rocca

doi:10.1055/s-0032-1315149

Flavonoid oligoglycosides from Ophioglossum vulgatum L. Having wound healing properties

Marco Clericuzio, Stefano Tinello, Bruno Burlando, Elia Ranzato, Simona Martinotti, Laura Cornara, Arianna La Rocca

Department of Science and Technological Innovation

Research output: Contribution to journal › Article › peer-review

Abstract

Two new glycosylated and acylated flavonols, viz. quercetin-3-O-[(6- caffeoyl)-β-glucopyranosyl (1→3) α-rhamnopyranoside]-7-O- α-rhamnopyranoside (2), and kaempferol-3-O-[(6-caffeoyl)-β- glucopyranosyl (1→3) α-rhamnopyranoside]-7-O-α-rhamnopyranoside (3), together with the known quercetin-3-O-methyl ether (1), were isolated from the aerial parts of the fern Ophioglossum vulgatum L. Their structures were established by means of 1D and 2D NMR spectra, as well as ESI-MS and ESI-HRMS spectra. Compounds 1-3 were all found to be active in scratch-wound healing assays on keratinocytes, with 3 being the most active one and showing maximum activity at 20μM.

Original language	English
Pages (from-to)	1639-1644
Number of pages	6
Journal	Planta Medica
Volume	78
Issue number	15
DOIs	https://doi.org/10.1055/s-0032-1315149
Publication status	Published - 2012

Keywords

Ophioglossaceae
Ophioglossum vulgatum L.
kaempferol acyl-glycosides
keratinocytes
quercetin acyl-glycosides
scratch-wound healing

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10.1055/s-0032-1315149

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title = "Flavonoid oligoglycosides from Ophioglossum vulgatum L. Having wound healing properties",

abstract = "Two new glycosylated and acylated flavonols, viz. quercetin-3-O-[(6- caffeoyl)-β-glucopyranosyl (1→3) α-rhamnopyranoside]-7-O- α-rhamnopyranoside (2), and kaempferol-3-O-[(6-caffeoyl)-β- glucopyranosyl (1→3) α-rhamnopyranoside]-7-O-α-rhamnopyranoside (3), together with the known quercetin-3-O-methyl ether (1), were isolated from the aerial parts of the fern Ophioglossum vulgatum L. Their structures were established by means of 1D and 2D NMR spectra, as well as ESI-MS and ESI-HRMS spectra. Compounds 1-3 were all found to be active in scratch-wound healing assays on keratinocytes, with 3 being the most active one and showing maximum activity at 20μM.",

keywords = "Ophioglossaceae, Ophioglossum vulgatum L., kaempferol acyl-glycosides, keratinocytes, quercetin acyl-glycosides, scratch-wound healing",

author = "Marco Clericuzio and Stefano Tinello and Bruno Burlando and Elia Ranzato and Simona Martinotti and Laura Cornara and {La Rocca}, Arianna",

year = "2012",

doi = "10.1055/s-0032-1315149",

language = "English",

volume = "78",

pages = "1639--1644",

journal = "Planta Medica",

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T1 - Flavonoid oligoglycosides from Ophioglossum vulgatum L. Having wound healing properties

AU - Clericuzio, Marco

AU - Tinello, Stefano

AU - Burlando, Bruno

AU - Ranzato, Elia

AU - Martinotti, Simona

AU - Cornara, Laura

AU - La Rocca, Arianna

PY - 2012

Y1 - 2012

N2 - Two new glycosylated and acylated flavonols, viz. quercetin-3-O-[(6- caffeoyl)-β-glucopyranosyl (1→3) α-rhamnopyranoside]-7-O- α-rhamnopyranoside (2), and kaempferol-3-O-[(6-caffeoyl)-β- glucopyranosyl (1→3) α-rhamnopyranoside]-7-O-α-rhamnopyranoside (3), together with the known quercetin-3-O-methyl ether (1), were isolated from the aerial parts of the fern Ophioglossum vulgatum L. Their structures were established by means of 1D and 2D NMR spectra, as well as ESI-MS and ESI-HRMS spectra. Compounds 1-3 were all found to be active in scratch-wound healing assays on keratinocytes, with 3 being the most active one and showing maximum activity at 20μM.

AB - Two new glycosylated and acylated flavonols, viz. quercetin-3-O-[(6- caffeoyl)-β-glucopyranosyl (1→3) α-rhamnopyranoside]-7-O- α-rhamnopyranoside (2), and kaempferol-3-O-[(6-caffeoyl)-β- glucopyranosyl (1→3) α-rhamnopyranoside]-7-O-α-rhamnopyranoside (3), together with the known quercetin-3-O-methyl ether (1), were isolated from the aerial parts of the fern Ophioglossum vulgatum L. Their structures were established by means of 1D and 2D NMR spectra, as well as ESI-MS and ESI-HRMS spectra. Compounds 1-3 were all found to be active in scratch-wound healing assays on keratinocytes, with 3 being the most active one and showing maximum activity at 20μM.

KW - Ophioglossaceae

KW - Ophioglossum vulgatum L.

KW - kaempferol acyl-glycosides

KW - keratinocytes

KW - quercetin acyl-glycosides

KW - scratch-wound healing

UR - http://www.scopus.com/inward/record.url?scp=84867874844&partnerID=8YFLogxK

U2 - 10.1055/s-0032-1315149

DO - 10.1055/s-0032-1315149

M3 - Article

SN - 0032-0943

VL - 78

SP - 1639

EP - 1644

JO - Planta Medica

JF - Planta Medica

IS - 15

ER -

Flavonoid oligoglycosides from Ophioglossum vulgatum L. Having wound healing properties

Abstract

Keywords

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