Flavonoid-induced autophagy in hormone sensitive breast cancer cells

Elisa Brunelli; Giulia Pinton; Paolo Bellini; Alberto Minassi; Giovanni Appendino; Laura Moro

doi:10.1016/j.fitote.2009.04.002

Flavonoid-induced autophagy in hormone sensitive breast cancer cells

Elisa Brunelli
, Giulia Pinton
, Paolo Bellini
, Alberto Minassi
, Giovanni Appendino
, Laura Moro

Department of Pharmaceutical Sciences

Research output: Contribution to journal › Article › peer-review

Abstract

The activity of 8-prenylapigenin (8-PA) and its 3'-methoxylated analogue isocannflavin B (IsoB) was investigated in estrogen-dependent T47-D and estrogen-independent MDA-MB-231 human breast cancer cell lines. 8-PA showed a biphasic effect on T47-D cell proliferation, while no significant effect was observed on MDA-MB-231 cells. Conversely, IsoB exhibited only an inhibitory effect on T47-D cell proliferation, accompanied by the appearance of an intense intracytoplasmic vacuolization of autophagic origin. Moreover, biochemical analysis showed that IsoB reduced Akt phosphorylation and p21^Cip1 expression in T47-D cells. These data show that the prenylflavone moiety is a versatile platform for the induction and modulation of bioactivity.

Original language	English
Pages (from-to)	327-332
Number of pages	6
Journal	Fitoterapia
Volume	80
Issue number	6
DOIs	https://doi.org/10.1016/j.fitote.2009.04.002
Publication status	Published - Sept 2009

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

Keywords

8-Prenylapigenin
8-Prenylnaringenin
Autophagy
Breast cancer cells
Cell signalling
Isocannflavin B

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10.1016/j.fitote.2009.04.002

Cite this

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title = "Flavonoid-induced autophagy in hormone sensitive breast cancer cells",

abstract = "The activity of 8-prenylapigenin (8-PA) and its 3'-methoxylated analogue isocannflavin B (IsoB) was investigated in estrogen-dependent T47-D and estrogen-independent MDA-MB-231 human breast cancer cell lines. 8-PA showed a biphasic effect on T47-D cell proliferation, while no significant effect was observed on MDA-MB-231 cells. Conversely, IsoB exhibited only an inhibitory effect on T47-D cell proliferation, accompanied by the appearance of an intense intracytoplasmic vacuolization of autophagic origin. Moreover, biochemical analysis showed that IsoB reduced Akt phosphorylation and p21Cip1 expression in T47-D cells. These data show that the prenylflavone moiety is a versatile platform for the induction and modulation of bioactivity.",

keywords = "8-Prenylapigenin, 8-Prenylnaringenin, Autophagy, Breast cancer cells, Cell signalling, Isocannflavin B",

author = "Elisa Brunelli and Giulia Pinton and Paolo Bellini and Alberto Minassi and Giovanni Appendino and Laura Moro",

note = "Funding Information: This work was supported by Miur and Regione Piemonte.",

year = "2009",

month = sep,

doi = "10.1016/j.fitote.2009.04.002",

language = "English",

volume = "80",

pages = "327--332",

journal = "Fitoterapia",

issn = "0367-326X",

publisher = "Elsevier B.V.",

number = "6",

}

TY - JOUR

T1 - Flavonoid-induced autophagy in hormone sensitive breast cancer cells

AU - Brunelli, Elisa

AU - Pinton, Giulia

AU - Bellini, Paolo

AU - Minassi, Alberto

AU - Appendino, Giovanni

AU - Moro, Laura

N1 - Funding Information: This work was supported by Miur and Regione Piemonte.

PY - 2009/9

Y1 - 2009/9

N2 - The activity of 8-prenylapigenin (8-PA) and its 3'-methoxylated analogue isocannflavin B (IsoB) was investigated in estrogen-dependent T47-D and estrogen-independent MDA-MB-231 human breast cancer cell lines. 8-PA showed a biphasic effect on T47-D cell proliferation, while no significant effect was observed on MDA-MB-231 cells. Conversely, IsoB exhibited only an inhibitory effect on T47-D cell proliferation, accompanied by the appearance of an intense intracytoplasmic vacuolization of autophagic origin. Moreover, biochemical analysis showed that IsoB reduced Akt phosphorylation and p21Cip1 expression in T47-D cells. These data show that the prenylflavone moiety is a versatile platform for the induction and modulation of bioactivity.

AB - The activity of 8-prenylapigenin (8-PA) and its 3'-methoxylated analogue isocannflavin B (IsoB) was investigated in estrogen-dependent T47-D and estrogen-independent MDA-MB-231 human breast cancer cell lines. 8-PA showed a biphasic effect on T47-D cell proliferation, while no significant effect was observed on MDA-MB-231 cells. Conversely, IsoB exhibited only an inhibitory effect on T47-D cell proliferation, accompanied by the appearance of an intense intracytoplasmic vacuolization of autophagic origin. Moreover, biochemical analysis showed that IsoB reduced Akt phosphorylation and p21Cip1 expression in T47-D cells. These data show that the prenylflavone moiety is a versatile platform for the induction and modulation of bioactivity.

KW - 8-Prenylapigenin

KW - 8-Prenylnaringenin

KW - Autophagy

KW - Breast cancer cells

KW - Cell signalling

KW - Isocannflavin B

UR - https://www.scopus.com/pages/publications/67650450192

U2 - 10.1016/j.fitote.2009.04.002

DO - 10.1016/j.fitote.2009.04.002

M3 - Article

SN - 0367-326X

VL - 80

SP - 327

EP - 332

JO - Fitoterapia

JF - Fitoterapia

IS - 6

ER -

Flavonoid-induced autophagy in hormone sensitive breast cancer cells

Abstract

UN SDGs

Keywords

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