Abstract
The activity of 8-prenylapigenin (8-PA) and its 3'-methoxylated analogue isocannflavin B (IsoB) was investigated in estrogen-dependent T47-D and estrogen-independent MDA-MB-231 human breast cancer cell lines. 8-PA showed a biphasic effect on T47-D cell proliferation, while no significant effect was observed on MDA-MB-231 cells. Conversely, IsoB exhibited only an inhibitory effect on T47-D cell proliferation, accompanied by the appearance of an intense intracytoplasmic vacuolization of autophagic origin. Moreover, biochemical analysis showed that IsoB reduced Akt phosphorylation and p21Cip1 expression in T47-D cells. These data show that the prenylflavone moiety is a versatile platform for the induction and modulation of bioactivity.
Original language | English |
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Pages (from-to) | 327-332 |
Number of pages | 6 |
Journal | Fitoterapia |
Volume | 80 |
Issue number | 6 |
DOIs | |
Publication status | Published - Sept 2009 |
Keywords
- 8-Prenylapigenin
- 8-Prenylnaringenin
- Autophagy
- Breast cancer cells
- Cell signalling
- Isocannflavin B