TY - JOUR
T1 - Fenoldopam for Renal Protection in Patients Undergoing Cardiopulmonary Bypass
AU - PP, CAIMMI
AU - PAGANI, L
AU - MICALIZZI, E
AU - FIUME, C
AU - GUANI, S
AU - BERNARDI, M
AU - PARODI, F
AU - CORDERO, G
AU - FREGONARA, M
AU - KAPETANAKIS, E
AU - PANELLA, Massimiliano
AU - DE, GASPERIS C.
PY - 2003
Y1 - 2003
N2 - OBJECTIVE:
To evaluate the possible protective effects of fenoldopam on renal function in patients undergoing cardiopulmonary bypass.
DESIGN:
Prospective, randomized trial.
SETTING:
University teaching hospital.
PARTICIPANTS:
One hundred sixty consecutive patients with serum creatinine >1.5 mg/dL who underwent uncomplicated moderate hypothermic cardiopulmonary bypass for cardiac surgery.
INTERVENTIONS:
A random group of 80 patients was managed conventionally (group A), whereas another random group of 80 patients received continuous intravenous administration of low-dose fenoldopam (0.1-0.3 microg/kg/min) during cardiopulmonary bypass and in the early postoperative period (group B).
MEASUREMENTS AND MAIN RESULTS:
An improvement of postoperative renal parameters were observed only in group B: preoperative serum creatinine 1.82 +/- 0.2 versus 1.43 +/- 0.73 postoperatively (p < 0.001), preoperative creatinine clearance 51.34 +/- 22.26 versus 67.14 +/- 18.55 postoperatively (p < 0.001).
CONCLUSIONS:
In this study, fenoldopam was an effective agent in the prevention of renal dysfunction after cardiopulmonary bypass
AB - OBJECTIVE:
To evaluate the possible protective effects of fenoldopam on renal function in patients undergoing cardiopulmonary bypass.
DESIGN:
Prospective, randomized trial.
SETTING:
University teaching hospital.
PARTICIPANTS:
One hundred sixty consecutive patients with serum creatinine >1.5 mg/dL who underwent uncomplicated moderate hypothermic cardiopulmonary bypass for cardiac surgery.
INTERVENTIONS:
A random group of 80 patients was managed conventionally (group A), whereas another random group of 80 patients received continuous intravenous administration of low-dose fenoldopam (0.1-0.3 microg/kg/min) during cardiopulmonary bypass and in the early postoperative period (group B).
MEASUREMENTS AND MAIN RESULTS:
An improvement of postoperative renal parameters were observed only in group B: preoperative serum creatinine 1.82 +/- 0.2 versus 1.43 +/- 0.73 postoperatively (p < 0.001), preoperative creatinine clearance 51.34 +/- 22.26 versus 67.14 +/- 18.55 postoperatively (p < 0.001).
CONCLUSIONS:
In this study, fenoldopam was an effective agent in the prevention of renal dysfunction after cardiopulmonary bypass
UR - https://iris.uniupo.it/handle/11579/14763
M3 - Article
SN - 1053-0770
VL - 17
SP - 491
EP - 494
JO - Journal of Cardiothoracic and Vascular Anesthesia
JF - Journal of Cardiothoracic and Vascular Anesthesia
ER -