Fateful music from a talented orchestra with a wicked conductor: Connection between oncogenic BRAF, ER stress, and autophagy in human melanoma

Paola Giglio; Gian Maria Fimia; Penny E. Lovat; Mauro Piacentini; Marco Corazzari

doi:10.4161/23723556.2014.995016

Fateful music from a talented orchestra with a wicked conductor: Connection between oncogenic BRAF, ER stress, and autophagy in human melanoma

Paola Giglio
, Gian Maria Fimia
, Penny E. Lovat
, Mauro Piacentini
, Marco Corazzari

Research output: Contribution to journal › Article › peer-review

Abstract

Autophagy and endoplasmic reticulum (ER) stress are involved in the development, progression, and chemoresistance of melanoma. We recently reported that oncogenic serine/threonine-protein kinase BRAF induces chronic ER stress, hence increasing baseline autophagy and promoting chemoresistance. The attenuation of ER stress restores basal autophagic activity and resensitizes melanoma cells to apoptosis.

Original language	English
Article number	e995016
Journal	Molecular and Cellular Oncology
Volume	2
Issue number	3
DOIs	https://doi.org/10.4161/23723556.2014.995016
Publication status	Published - 3 Jul 2015
Externally published	Yes

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

Keywords

BRAF
ER stress
autophagy
cancer
melanoma

Access to Document

10.4161/23723556.2014.995016

Cite this

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title = "Fateful music from a talented orchestra with a wicked conductor: Connection between oncogenic BRAF, ER stress, and autophagy in human melanoma",

abstract = "Autophagy and endoplasmic reticulum (ER) stress are involved in the development, progression, and chemoresistance of melanoma. We recently reported that oncogenic serine/threonine-protein kinase BRAF induces chronic ER stress, hence increasing baseline autophagy and promoting chemoresistance. The attenuation of ER stress restores basal autophagic activity and resensitizes melanoma cells to apoptosis.",

keywords = "BRAF, ER stress, autophagy, cancer, melanoma",

author = "Paola Giglio and Fimia, \{Gian Maria\} and Lovat, \{Penny E.\} and Mauro Piacentini and Marco Corazzari",

note = "Publisher Copyright: {\textcopyright} 2015, {\textcopyright} 2015 The Author(s). Published with license by Taylor \& Francis Group, LLC. {\textcopyright} 2015, {\textcopyright} Paola Giglio, Gian Maria Fimia, Penny E Lovat, Mauro Piacentini, and Marco Corazzari.",

year = "2015",

month = jul,

day = "3",

doi = "10.4161/23723556.2014.995016",

language = "English",

volume = "2",

journal = "Molecular and Cellular Oncology",

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}

TY - JOUR

T1 - Fateful music from a talented orchestra with a wicked conductor

T2 - Connection between oncogenic BRAF, ER stress, and autophagy in human melanoma

AU - Giglio, Paola

AU - Fimia, Gian Maria

AU - Lovat, Penny E.

AU - Piacentini, Mauro

AU - Corazzari, Marco

N1 - Publisher Copyright: © 2015, © 2015 The Author(s). Published with license by Taylor & Francis Group, LLC. © 2015, © Paola Giglio, Gian Maria Fimia, Penny E Lovat, Mauro Piacentini, and Marco Corazzari.

PY - 2015/7/3

Y1 - 2015/7/3

N2 - Autophagy and endoplasmic reticulum (ER) stress are involved in the development, progression, and chemoresistance of melanoma. We recently reported that oncogenic serine/threonine-protein kinase BRAF induces chronic ER stress, hence increasing baseline autophagy and promoting chemoresistance. The attenuation of ER stress restores basal autophagic activity and resensitizes melanoma cells to apoptosis.

AB - Autophagy and endoplasmic reticulum (ER) stress are involved in the development, progression, and chemoresistance of melanoma. We recently reported that oncogenic serine/threonine-protein kinase BRAF induces chronic ER stress, hence increasing baseline autophagy and promoting chemoresistance. The attenuation of ER stress restores basal autophagic activity and resensitizes melanoma cells to apoptosis.

KW - BRAF

KW - ER stress

KW - autophagy

KW - cancer

KW - melanoma

U2 - 10.4161/23723556.2014.995016

DO - 10.4161/23723556.2014.995016

M3 - Article

SN - 2372-3556

VL - 2

JO - Molecular and Cellular Oncology

JF - Molecular and Cellular Oncology

IS - 3

M1 - e995016

ER -

Fateful music from a talented orchestra with a wicked conductor: Connection between oncogenic BRAF, ER stress, and autophagy in human melanoma

Abstract

UN SDGs

Keywords

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