Fatality rate and predictors of mortality in an Italian cohort of hospitalized COVID-19 patients

Mattia BELLAN; Giuseppe Rocco Salvatore Patti; E Hayden; D Azzolina; Mario PIRISI; A Acquaviva; Gianluca AIMARETTI; Paolo ALUFFI VALLETTI; R Angilletta; R Arioli; GC Avanzi; G Avino; PE Balbo; G Baldon; F Baorda; E Barbero; A Baricich; M Barini; Francesco BARONE ADESI; S Battistini; M Beltrame; M Bertoli; S Bertolin; M Bertolotti; M Betti; F Bobbio; PAOLO BOFFANO; Lucio BOGLIONE; S Borrè; Matteo BRUCOLI; E Calzaducca; E Cammarata; Vincenzo CANTALUPPI; R Cantello; A Capponi; Alessandro CARRIERO; FG Casciaro; Luigi Mario CASTELLO; F Ceruti; G Chichino; E Chirico; C Cisari; MG Cittone; C Colombo; Cristoforo COMI; E Croce; T Daffara; P Danna; F Della Corte; S De Vecchi; Umberto DIANZANI; D Di Benedetto; E Esposto; Fabrizio FAGGIANO; Z Falaschi; Daniela FERRANTE; A Ferrero; I Gagliardi; Gianluca GAIDANO; A Galbiati; S Gallo; PL Garavelli; CA Gardino; Massimiliano GARZARO; ML Gastaldello; Francesco GAVELLI; Alessandra Gennari; GM Giacomini; I Giacone; V Giai Via; F Giolitti; LC Gironi; Carla Maria Gramaglia; L Grisafi; I Inserra; MARCO INVERNIZZI; M Krengli; E Labella; IC Landi; R Landi; I Leone; V Lio; L Lorenzini; A Maconi; Mario MALERBA; GF Manfredi; M Martelli; L Marzari; Paolo MARZULLO; MARCO GIOVANNI MENNUNI; C Montabone; U Morosini; M Mussa; I Nerici; A Nuzzo; C Olivieri; SA Padelli; Massimiliano PANELLA; A Parisini; A Paschè; A Pau; AR Pedrinelli; I Percivale; R Re; Cristina RIGAMONTI; E Rizzi; A Rognoni; A Roveta; L Salamina; M Santagostino; M Saraceno; Paola SAVOIA; M Sciarra; A Schimmenti; Lorenza Scotti; E Spinoni; Carlo SMIRNE; V Tarantino; PA Tillio; Rosanna VASCHETTO; V Vassia; D Zagaria; Elisa ZAVATTARO; Patrizia ZEPPEGNO; F Zottarelli; Pier Paolo SAINAGHI

doi:10.1038/s41598-020-77698-4

Fatality rate and predictors of mortality in an Italian cohort of hospitalized COVID-19 patients

Mattia BELLAN, Giuseppe Rocco Salvatore Patti, E Hayden, D Azzolina, Mario PIRISI, A Acquaviva, Gianluca AIMARETTI, Paolo ALUFFI VALLETTI, R Angilletta, R Arioli, GC Avanzi, G Avino, PE Balbo, G Baldon, F Baorda, E Barbero, A Baricich, M Barini, Francesco BARONE ADESI, S BattistiniM Beltrame, M Bertoli, S Bertolin, M Bertolotti, M Betti, F Bobbio, PAOLO BOFFANO, Lucio BOGLIONE, S Borrè, Matteo BRUCOLI, E Calzaducca, E Cammarata, Vincenzo CANTALUPPI, R Cantello, A Capponi, Alessandro CARRIERO, FG Casciaro, Luigi Mario CASTELLO, F Ceruti, G Chichino, E Chirico, C Cisari, MG Cittone, C Colombo, Cristoforo COMI, E Croce, T Daffara, P Danna, F Della Corte, S De Vecchi, Umberto DIANZANI, D Di Benedetto, E Esposto, Fabrizio FAGGIANO, Z Falaschi, Daniela FERRANTE, A Ferrero, I Gagliardi, Gianluca GAIDANO, A Galbiati, S Gallo, PL Garavelli, CA Gardino, Massimiliano GARZARO, ML Gastaldello, Francesco GAVELLI, Alessandra Gennari, GM Giacomini, I Giacone, V Giai Via, F Giolitti, LC Gironi, Carla Maria Gramaglia, L Grisafi, I Inserra, MARCO INVERNIZZI, M Krengli, E Labella, IC Landi, R Landi, I Leone, V Lio, L Lorenzini, A Maconi, Mario MALERBA, GF Manfredi, M Martelli, L Marzari, Paolo MARZULLO, MARCO GIOVANNI MENNUNI, C Montabone, U Morosini, M Mussa, I Nerici, A Nuzzo, C Olivieri, SA Padelli, Massimiliano PANELLA, A Parisini, A Paschè, A Pau, AR Pedrinelli, I Percivale, R Re, Cristina RIGAMONTI, E Rizzi, A Rognoni, A Roveta, L Salamina, M Santagostino, M Saraceno, Paola SAVOIA, M Sciarra, A Schimmenti, Lorenza Scotti, E Spinoni, Carlo SMIRNE, V Tarantino, PA Tillio, Rosanna VASCHETTO, V Vassia, D Zagaria, Elisa ZAVATTARO, Patrizia ZEPPEGNO, F Zottarelli, Pier Paolo SAINAGHI

Research output: Contribution to journal › Article › peer-review

Abstract

Clinical features and natural history of coronavirus disease 2019 (COVID‑19) differ widely among different countries and during different phases of the pandemia. Here, we aimed to evaluate the case fatality rate (CFR) and to identify predictors of mortality in a cohort of COVID‑19 patients admitted to three hospitals of Northern Italy between March 1 and April 28, 2020. All these patients had a confirmed diagnosis of SARS‑CoV‑2 infection by molecular methods. During the study period 504/1697 patients died; thus, overall CFR was 29.7%. We looked for predictors of mortality in a subgroup of 486 patients (239 males, 59%; median age 71 years) for whom sufficient clinical data were available at data cut‑off. Among the demographic and clinical variables considered, age, a diagnosis of cancer, obesity and current smoking independently predicted mortality. When laboratory data were added to the model in a further subgroup of patients, age, the diagnosis of cancer, and the baseline PaO2/FiO2 ratio were identified as independent predictors of mortality. In conclusion, the CFR of hospitalized patients in Northern Italy during the ascending phase of the COVID‑19 pandemic approached 30%. The identification of mortality predictors might contribute to better stratification of individual patient risk.

Original language	English
Journal	Scientific Reports
Volume	10
Issue number	1
DOIs	https://doi.org/10.1038/s41598-020-77698-4
Publication status	Published - 2020

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

Access to Document

10.1038/s41598-020-77698-4

https://hdl.handle.net/11579/118463

Cite this

BELLAN, M., Patti, G. R. S., Hayden, E., Azzolina, D., PIRISI, M., Acquaviva, A., AIMARETTI, G., ALUFFI VALLETTI, P., Angilletta, R., Arioli, R., Avanzi, GC., Avino, G., Balbo, PE., Baldon, G., Baorda, F., Barbero, E., Baricich, A., Barini, M., BARONE ADESI, F., ... SAINAGHI, P. P. (2020). Fatality rate and predictors of mortality in an Italian cohort of hospitalized COVID-19 patients. Scientific Reports, 10(1). https://doi.org/10.1038/s41598-020-77698-4

@article{7e133f0078754d168c6afc4c96d06530,

title = "Fatality rate and predictors of mortality in an Italian cohort of hospitalized COVID-19 patients",

abstract = "Clinical features and natural history of coronavirus disease 2019 (COVID‑19) differ widely among different countries and during different phases of the pandemia. Here, we aimed to evaluate the case fatality rate (CFR) and to identify predictors of mortality in a cohort of COVID‑19 patients admitted to three hospitals of Northern Italy between March 1 and April 28, 2020. All these patients had a confirmed diagnosis of SARS‑CoV‑2 infection by molecular methods. During the study period 504/1697 patients died; thus, overall CFR was 29.7%. We looked for predictors of mortality in a subgroup of 486 patients (239 males, 59%; median age 71 years) for whom sufficient clinical data were available at data cut‑off. Among the demographic and clinical variables considered, age, a diagnosis of cancer, obesity and current smoking independently predicted mortality. When laboratory data were added to the model in a further subgroup of patients, age, the diagnosis of cancer, and the baseline PaO2/FiO2 ratio were identified as independent predictors of mortality. In conclusion, the CFR of hospitalized patients in Northern Italy during the ascending phase of the COVID‑19 pandemic approached 30%. The identification of mortality predictors might contribute to better stratification of individual patient risk.",

author = "Mattia BELLAN and Patti, {Giuseppe Rocco Salvatore} and E Hayden and D Azzolina and Mario PIRISI and A Acquaviva and Gianluca AIMARETTI and {ALUFFI VALLETTI}, Paolo and R Angilletta and R Arioli and GC Avanzi and G Avino and PE Balbo and G Baldon and F Baorda and E Barbero and A Baricich and M Barini and {BARONE ADESI}, Francesco and S Battistini and M Beltrame and M Bertoli and S Bertolin and M Bertolotti and M Betti and F Bobbio and PAOLO BOFFANO and Lucio BOGLIONE and S Borr{\`e} and Matteo BRUCOLI and E Calzaducca and E Cammarata and Vincenzo CANTALUPPI and R Cantello and A Capponi and Alessandro CARRIERO and FG Casciaro and CASTELLO, {Luigi Mario} and F Ceruti and G Chichino and E Chirico and C Cisari and MG Cittone and C Colombo and Cristoforo COMI and E Croce and T Daffara and P Danna and {Della Corte}, F and {De Vecchi}, S and Umberto DIANZANI and {Di Benedetto}, D and E Esposto and Fabrizio FAGGIANO and Z Falaschi and Daniela FERRANTE and A Ferrero and I Gagliardi and Gianluca GAIDANO and A Galbiati and S Gallo and PL Garavelli and CA Gardino and Massimiliano GARZARO and ML Gastaldello and Francesco GAVELLI and Alessandra Gennari and GM Giacomini and I Giacone and {Giai Via}, V and F Giolitti and LC Gironi and Gramaglia, {Carla Maria} and L Grisafi and I Inserra and MARCO INVERNIZZI and M Krengli and E Labella and IC Landi and R Landi and I Leone and V Lio and L Lorenzini and A Maconi and Mario MALERBA and GF Manfredi and M Martelli and L Marzari and Paolo MARZULLO and MENNUNI, {MARCO GIOVANNI} and C Montabone and U Morosini and M Mussa and I Nerici and A Nuzzo and C Olivieri and SA Padelli and Massimiliano PANELLA and A Parisini and A Pasch{\`e} and A Pau and AR Pedrinelli and I Percivale and R Re and Cristina RIGAMONTI and E Rizzi and A Rognoni and A Roveta and L Salamina and M Santagostino and M Saraceno and Paola SAVOIA and M Sciarra and A Schimmenti and Lorenza Scotti and E Spinoni and Carlo SMIRNE and V Tarantino and PA Tillio and Rosanna VASCHETTO and V Vassia and D Zagaria and Elisa ZAVATTARO and Patrizia ZEPPEGNO and F Zottarelli and SAINAGHI, {Pier Paolo}",

note = "Publisher Copyright: {\textcopyright} 2020, The Author(s).",

year = "2020",

doi = "10.1038/s41598-020-77698-4",

language = "English",

volume = "10",

journal = "Scientific Reports",

issn = "2045-2322",

publisher = "Nature Publishing Group",

number = "1",

}

BELLAN, M , Patti, GRS, Hayden, E, Azzolina, D, PIRISI, M, Acquaviva, A, AIMARETTI, G , ALUFFI VALLETTI, P, Angilletta, R, Arioli, R, Avanzi, GC, Avino, G, Balbo, PE, Baldon, G, Baorda, F, Barbero, E, Baricich, A, Barini, M, BARONE ADESI, F, Battistini, S, Beltrame, M, Bertoli, M, Bertolin, S, Bertolotti, M, Betti, M, Bobbio, F, BOFFANO, PAOLO , BOGLIONE, L, Borrè, S, BRUCOLI, M, Calzaducca, E, Cammarata, E, CANTALUPPI, V, Cantello, R, Capponi, A, CARRIERO, A, Casciaro, FG, CASTELLO, LM, Ceruti, F, Chichino, G, Chirico, E, Cisari, C, Cittone, MG, Colombo, C, COMI, C, Croce, E, Daffara, T, Danna, P, Della Corte, F, De Vecchi, S, DIANZANI, U, Di Benedetto, D, Esposto, E, FAGGIANO, F, Falaschi, Z, FERRANTE, D, Ferrero, A, Gagliardi, I, GAIDANO, G, Galbiati, A, Gallo, S, Garavelli, PL, Gardino, CA, GARZARO, M, Gastaldello, ML, GAVELLI, F , Gennari, A, Giacomini, GM, Giacone, I, Giai Via, V, Giolitti, F, Gironi, LC, Gramaglia, CM, Grisafi, L, Inserra, I, INVERNIZZI, MARCO, Krengli, M, Labella, E, Landi, IC, Landi, R, Leone, I, Lio, V, Lorenzini, L, Maconi, A, MALERBA, M, Manfredi, GF, Martelli, M, Marzari, L, MARZULLO, P , MENNUNI, MARCOGIOVANNI, Montabone, C, Morosini, U, Mussa, M, Nerici, I, Nuzzo, A, Olivieri, C, Padelli, SA, PANELLA, M, Parisini, A, Paschè, A, Pau, A, Pedrinelli, AR, Percivale, I, Re, R, RIGAMONTI, C, Rizzi, E, Rognoni, A, Roveta, A, Salamina, L, Santagostino, M, Saraceno, M, SAVOIA, P, Sciarra, M, Schimmenti, A, Scotti, L, Spinoni, E, SMIRNE, C, Tarantino, V, Tillio, PA, VASCHETTO, R, Vassia, V, Zagaria, D, ZAVATTARO, E , ZEPPEGNO, P, Zottarelli, F & SAINAGHI, PP 2020, 'Fatality rate and predictors of mortality in an Italian cohort of hospitalized COVID-19 patients', Scientific Reports, vol. 10, no. 1. https://doi.org/10.1038/s41598-020-77698-4

TY - JOUR

T1 - Fatality rate and predictors of mortality in an Italian cohort of hospitalized COVID-19 patients

AU - BELLAN, Mattia

AU - Patti, Giuseppe Rocco Salvatore

AU - Hayden, E

AU - Azzolina, D

AU - PIRISI, Mario

AU - Acquaviva, A

AU - AIMARETTI, Gianluca

AU - ALUFFI VALLETTI, Paolo

AU - Angilletta, R

AU - Arioli, R

AU - Avanzi, GC

AU - Avino, G

AU - Balbo, PE

AU - Baldon, G

AU - Baorda, F

AU - Barbero, E

AU - Baricich, A

AU - Barini, M

AU - BARONE ADESI, Francesco

AU - Battistini, S

AU - Beltrame, M

AU - Bertoli, M

AU - Bertolin, S

AU - Bertolotti, M

AU - Betti, M

AU - Bobbio, F

AU - BOFFANO, PAOLO

AU - BOGLIONE, Lucio

AU - Borrè, S

AU - BRUCOLI, Matteo

AU - Calzaducca, E

AU - Cammarata, E

AU - CANTALUPPI, Vincenzo

AU - Cantello, R

AU - Capponi, A

AU - CARRIERO, Alessandro

AU - Casciaro, FG

AU - CASTELLO, Luigi Mario

AU - Ceruti, F

AU - Chichino, G

AU - Chirico, E

AU - Cisari, C

AU - Cittone, MG

AU - Colombo, C

AU - COMI, Cristoforo

AU - Croce, E

AU - Daffara, T

AU - Danna, P

AU - Della Corte, F

AU - De Vecchi, S

AU - DIANZANI, Umberto

AU - Di Benedetto, D

AU - Esposto, E

AU - FAGGIANO, Fabrizio

AU - Falaschi, Z

AU - FERRANTE, Daniela

AU - Ferrero, A

AU - Gagliardi, I

AU - GAIDANO, Gianluca

AU - Galbiati, A

AU - Gallo, S

AU - Garavelli, PL

AU - Gardino, CA

AU - GARZARO, Massimiliano

AU - Gastaldello, ML

AU - GAVELLI, Francesco

AU - Gennari, Alessandra

AU - Giacomini, GM

AU - Giacone, I

AU - Giai Via, V

AU - Giolitti, F

AU - Gironi, LC

AU - Gramaglia, Carla Maria

AU - Grisafi, L

AU - Inserra, I

AU - INVERNIZZI, MARCO

AU - Krengli, M

AU - Labella, E

AU - Landi, IC

AU - Landi, R

AU - Leone, I

AU - Lio, V

AU - Lorenzini, L

AU - Maconi, A

AU - MALERBA, Mario

AU - Manfredi, GF

AU - Martelli, M

AU - Marzari, L

AU - MARZULLO, Paolo

AU - MENNUNI, MARCO GIOVANNI

AU - Montabone, C

AU - Morosini, U

AU - Mussa, M

AU - Nerici, I

AU - Nuzzo, A

AU - Olivieri, C

AU - Padelli, SA

AU - PANELLA, Massimiliano

AU - Parisini, A

AU - Paschè, A

AU - Pau, A

AU - Pedrinelli, AR

AU - Percivale, I

AU - Re, R

AU - RIGAMONTI, Cristina

AU - Rizzi, E

AU - Rognoni, A

AU - Roveta, A

AU - Salamina, L

AU - Santagostino, M

AU - Saraceno, M

AU - SAVOIA, Paola

AU - Sciarra, M

AU - Schimmenti, A

AU - Scotti, Lorenza

AU - Spinoni, E

AU - SMIRNE, Carlo

AU - Tarantino, V

AU - Tillio, PA

AU - VASCHETTO, Rosanna

AU - Vassia, V

AU - Zagaria, D

AU - ZAVATTARO, Elisa

AU - ZEPPEGNO, Patrizia

AU - Zottarelli, F

AU - SAINAGHI, Pier Paolo

PY - 2020

Y1 - 2020

N2 - Clinical features and natural history of coronavirus disease 2019 (COVID‑19) differ widely among different countries and during different phases of the pandemia. Here, we aimed to evaluate the case fatality rate (CFR) and to identify predictors of mortality in a cohort of COVID‑19 patients admitted to three hospitals of Northern Italy between March 1 and April 28, 2020. All these patients had a confirmed diagnosis of SARS‑CoV‑2 infection by molecular methods. During the study period 504/1697 patients died; thus, overall CFR was 29.7%. We looked for predictors of mortality in a subgroup of 486 patients (239 males, 59%; median age 71 years) for whom sufficient clinical data were available at data cut‑off. Among the demographic and clinical variables considered, age, a diagnosis of cancer, obesity and current smoking independently predicted mortality. When laboratory data were added to the model in a further subgroup of patients, age, the diagnosis of cancer, and the baseline PaO2/FiO2 ratio were identified as independent predictors of mortality. In conclusion, the CFR of hospitalized patients in Northern Italy during the ascending phase of the COVID‑19 pandemic approached 30%. The identification of mortality predictors might contribute to better stratification of individual patient risk.

AB - Clinical features and natural history of coronavirus disease 2019 (COVID‑19) differ widely among different countries and during different phases of the pandemia. Here, we aimed to evaluate the case fatality rate (CFR) and to identify predictors of mortality in a cohort of COVID‑19 patients admitted to three hospitals of Northern Italy between March 1 and April 28, 2020. All these patients had a confirmed diagnosis of SARS‑CoV‑2 infection by molecular methods. During the study period 504/1697 patients died; thus, overall CFR was 29.7%. We looked for predictors of mortality in a subgroup of 486 patients (239 males, 59%; median age 71 years) for whom sufficient clinical data were available at data cut‑off. Among the demographic and clinical variables considered, age, a diagnosis of cancer, obesity and current smoking independently predicted mortality. When laboratory data were added to the model in a further subgroup of patients, age, the diagnosis of cancer, and the baseline PaO2/FiO2 ratio were identified as independent predictors of mortality. In conclusion, the CFR of hospitalized patients in Northern Italy during the ascending phase of the COVID‑19 pandemic approached 30%. The identification of mortality predictors might contribute to better stratification of individual patient risk.

UR - https://iris.uniupo.it/handle/11579/118463

U2 - 10.1038/s41598-020-77698-4

DO - 10.1038/s41598-020-77698-4

M3 - Article

SN - 2045-2322

VL - 10

JO - Scientific Reports

JF - Scientific Reports

IS - 1

ER -

Fatality rate and predictors of mortality in an Italian cohort of hospitalized COVID-19 patients

Abstract

UN SDGs

Access to Document

Other files and links

Fingerprint

Cite this