Expeditious N-monoalkylation of 1,4,7,10-tetraazacyclododecane (cyclen) via formamido protection

Keyphrases

• 1,4,7,10-tetraazacyclododecane 100%
• Monofluoroalkylation 100%
• Macrocycles 33%
• Alkylation 33%
• Monosubstituted 33%
• Excellent Yields 33%
• Chloral Hydrate 33%
• Selective Entry 33%
• Formyl Group 33%
• Electrophile 33%

Chemistry

• 1,4,7,10-tetraazacyclododecane 100%
• Macrocycle 33%
• Electrophile 33%
• Formyl Group 33%
• Chloral Hydrate 33%