Expeditious N-monoalkylation of 1,4,7,10-tetraazacyclododecane (cyclen) via formamido protection

V. Boldrini, G. B. Giovenzana, Roberto Pagliarin, G. Palmisano, M. Sisti

Research output: Contribution to journalArticlepeer-review

Abstract

The reaction of cyclen 1 with chloral hydrate afforded exclusively 1,4,7-triformylcyclen 2 in high yield; the triprotected macrocycle was easily alkylated with various electrophiles in good to excellent yields. The alkaline removal of the formyl groups provided a selective entry into N-monosubstituted cyclen derivatives.

Original languageEnglish
Pages (from-to)6527-6530
Number of pages4
JournalTetrahedron Letters
Volume41
Issue number33
DOIs
Publication statusPublished - 12 Aug 2000

Fingerprint

Dive into the research topics of 'Expeditious N-monoalkylation of 1,4,7,10-tetraazacyclododecane (cyclen) via formamido protection'. Together they form a unique fingerprint.

Cite this