Expanding the causes of Fever of Unknown Origin in immunocompromised patients: report of two cases highlighting the role of SARS-CoV-2

Carmelina Calitri; Francesca Romano; Andrea Perinzano; Barbara Rizzello; Marco Domenico Carbutto; Fabio Antonino Ranzani; Roberto Angilletta; Marco Mussa; Andrea CALCAGNO

doi:10.53854/liim-3304-10

Expanding the causes of Fever of Unknown Origin in immunocompromised patients: report of two cases highlighting the role of SARS-CoV-2

Carmelina Calitri
, Francesca Romano
, Andrea Perinzano
, Barbara Rizzello
, Marco Domenico Carbutto
, Fabio Antonino Ranzani
, Roberto Angilletta
, Marco Mussa
, Andrea CALCAGNO

Department of Translational Medicine

Research output: Contribution to journal › Article › peer-review

Abstract

Fever of Unknown Origin (FUO) remains a diagnostic challenge for clinicians, with multiple infectious and non-infectious etiologies. SARS-CoV-2 can determine a prolonged viral shedding in the immunocompromised host, firstly in those receiving B-cell targeted therapies, being responsible of persistent infection which may configure as a FUO. We report two cases of long-lasting fever in patients with multiple sclerosis and B-cell depletion, finally diagnosed as COVID-19. We suggest the inclusion of SARS-CoV-2 testing in the differential diagnosis of FUO.

Original language	English
Pages (from-to)	448-452
Number of pages	5
Journal	LE INFEZIONI IN MEDICINA
Volume	33
Issue number	4
DOIs	https://doi.org/10.53854/liim-3304-10
Publication status	Published - 2025

Keywords

B-cell depletion
FUO
SARS-CoV-2
immunocompromised host

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10.53854/liim-3304-10

https://hdl.handle.net/11579/229722

Cite this

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abstract = "Fever of Unknown Origin (FUO) remains a diagnostic challenge for clinicians, with multiple infectious and non-infectious etiologies. SARS-CoV-2 can determine a prolonged viral shedding in the immunocompromised host, firstly in those receiving B-cell targeted therapies, being responsible of persistent infection which may configure as a FUO. We report two cases of long-lasting fever in patients with multiple sclerosis and B-cell depletion, finally diagnosed as COVID-19. We suggest the inclusion of SARS-CoV-2 testing in the differential diagnosis of FUO.",

keywords = "B-cell depletion, FUO, SARS-CoV-2, immunocompromised host, B-cell depletion, FUO, SARS-CoV-2, immunocompromised host",

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AU - Calitri, Carmelina

AU - Romano, Francesca

AU - Perinzano, Andrea

AU - Rizzello, Barbara

AU - Carbutto, Marco Domenico

AU - Ranzani, Fabio Antonino

AU - Angilletta, Roberto

AU - Mussa, Marco

AU - CALCAGNO, Andrea

PY - 2025

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AB - Fever of Unknown Origin (FUO) remains a diagnostic challenge for clinicians, with multiple infectious and non-infectious etiologies. SARS-CoV-2 can determine a prolonged viral shedding in the immunocompromised host, firstly in those receiving B-cell targeted therapies, being responsible of persistent infection which may configure as a FUO. We report two cases of long-lasting fever in patients with multiple sclerosis and B-cell depletion, finally diagnosed as COVID-19. We suggest the inclusion of SARS-CoV-2 testing in the differential diagnosis of FUO.

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KW - FUO

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KW - immunocompromised host

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KW - FUO

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KW - immunocompromised host

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M3 - Article

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ER -

Expanding the causes of Fever of Unknown Origin in immunocompromised patients: report of two cases highlighting the role of SARS-CoV-2

Abstract

Keywords

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