Evolving concepts in the management of drug resistant ovarian cancer: Dose dense chemotherapy and the reversal of clinical platinum resistance

David J. Pinato, Janet Graham, Hani Gabra, Rohini Sharma

Research output: Contribution to journalReview articlepeer-review

Abstract

Despite the initially high response rate to standard front-line debulking surgery followed by platinum-based chemotherapy, the relapse rate in ovarian cancer is high and many patients will recur within 6. months of completing platinum based treatment. These patients may still require further chemotherapy despite being considered " platinum resistant" In this setting, response rates to conventionally scheduled second line platinum and non-platinum agents is low, ranging between 5% and 15%. There is an emerging body of evidence that in this scenario, chemotherapeutic activity can be enhanced using unconventionally scheduled " dose-dense" platinum and non-platinum based regimens with improved response rates of up to 65%. Randomised studies to evaluate the impact of this approach on survival in recurrent, platinum resistant disease are urgently required to confirm the promising phase II findings if there is to be a change in the standard of care of patients with platinum resistant disease. In this review we discuss the evolving strategies to overcome resistance in patients with platinum resistant ovarian cancer with a particular focus on alterations in dose schedule as a means of reversing platinum resistance.

Original languageEnglish
Pages (from-to)153-160
Number of pages8
JournalCancer Treatment Reviews
Volume39
Issue number2
DOIs
Publication statusPublished - Apr 2013
Externally publishedYes

Keywords

  • Chemotherapy
  • Dose-dense
  • Ovarian cancer
  • Paclitaxel
  • Platinum
  • Relapse
  • Resistant

Fingerprint

Dive into the research topics of 'Evolving concepts in the management of drug resistant ovarian cancer: Dose dense chemotherapy and the reversal of clinical platinum resistance'. Together they form a unique fingerprint.

Cite this