Evidence for the involvement of distinct voltage-sensitive calcium channels in the release of 3H-dopamine from primary cultures of mesencephalic neurons

M. G. Grilli; A. G. Wright; I. Hanbauer

doi:10.1016/0028-3908(89)90222-0

Evidence for the involvement of distinct voltage-sensitive calcium channels in the release of ³H-dopamine from primary cultures of mesencephalic neurons

M. G. Grilli
, A. G. Wright
, I. Hanbauer

Research output: Contribution to journal › Article › peer-review

Abstract

In ventral mesencephalic neurons cultured for five days the K⁺-evoked ³H-dopamine release is mediated through activation of N-type Ca²⁺ channels, while L- or T-type channels appear to be inactive. In contrast, veratridine-elicited release of ³H-dopamine that was attenuated by tetrodotoxin was not altered by N-, L-, nor T-type Ca²⁺ channel blockers.

Original language	English
Pages (from-to)	1275-1278
Number of pages	4
Journal	Neuropharmacology
Volume	28
Issue number	11
DOIs	https://doi.org/10.1016/0028-3908(89)90222-0
Publication status	Published - Nov 1989
Externally published	Yes

Keywords

Ca channels
Dopamine release
membrane depolarization
primary cultures
ventral mesencephalic neurons

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10.1016/0028-3908(89)90222-0

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title = "Evidence for the involvement of distinct voltage-sensitive calcium channels in the release of 3H-dopamine from primary cultures of mesencephalic neurons",

abstract = "In ventral mesencephalic neurons cultured for five days the K+-evoked 3H-dopamine release is mediated through activation of N-type Ca2+ channels, while L- or T-type channels appear to be inactive. In contrast, veratridine-elicited release of 3H-dopamine that was attenuated by tetrodotoxin was not altered by N-, L-, nor T-type Ca2+ channel blockers.",

keywords = "Ca channels, Dopamine release, membrane depolarization, primary cultures, ventral mesencephalic neurons",

author = "Grilli, \{M. G.\} and Wright, \{A. G.\} and I. Hanbauer",

note = "Funding Information: Dr. M.G. Grilli was supported by a research grant from FIDIA, Abano Terme, Italy. Di Porzio and E. Costa for their stimulatingI nterest and advice.",

year = "1989",

month = nov,

doi = "10.1016/0028-3908(89)90222-0",

language = "English",

volume = "28",

pages = "1275--1278",

journal = "Neuropharmacology",

issn = "0028-3908",

publisher = "Elsevier Ltd.",

number = "11",

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TY - JOUR

T1 - Evidence for the involvement of distinct voltage-sensitive calcium channels in the release of 3H-dopamine from primary cultures of mesencephalic neurons

AU - Grilli, M. G.

AU - Wright, A. G.

AU - Hanbauer, I.

N1 - Funding Information: Dr. M.G. Grilli was supported by a research grant from FIDIA, Abano Terme, Italy. Di Porzio and E. Costa for their stimulatingI nterest and advice.

PY - 1989/11

Y1 - 1989/11

N2 - In ventral mesencephalic neurons cultured for five days the K+-evoked 3H-dopamine release is mediated through activation of N-type Ca2+ channels, while L- or T-type channels appear to be inactive. In contrast, veratridine-elicited release of 3H-dopamine that was attenuated by tetrodotoxin was not altered by N-, L-, nor T-type Ca2+ channel blockers.

AB - In ventral mesencephalic neurons cultured for five days the K+-evoked 3H-dopamine release is mediated through activation of N-type Ca2+ channels, while L- or T-type channels appear to be inactive. In contrast, veratridine-elicited release of 3H-dopamine that was attenuated by tetrodotoxin was not altered by N-, L-, nor T-type Ca2+ channel blockers.

KW - Ca channels

KW - Dopamine release

KW - membrane depolarization

KW - primary cultures

KW - ventral mesencephalic neurons

UR - https://www.scopus.com/pages/publications/0024420233

U2 - 10.1016/0028-3908(89)90222-0

DO - 10.1016/0028-3908(89)90222-0

M3 - Article

SN - 0028-3908

VL - 28

SP - 1275

EP - 1278

JO - Neuropharmacology

JF - Neuropharmacology

IS - 11

ER -

Evidence for the involvement of distinct voltage-sensitive calcium channels in the release of ³H-dopamine from primary cultures of mesencephalic neurons

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