Estrogen Derivatives of Transition-Metal Complexes for Analytical Detection Enhancement

Domenico Osella; Olimpia Gambino; Carlo Nervi; Edison Stein; Gerard Jaouen; Anne Vessiéres

doi:10.1021/om00020a027

Estrogen Derivatives of Transition-Metal Complexes for Analytical Detection Enhancement

Domenico Osella
, Olimpia Gambino
, Carlo Nervi
, Edison Stein
, Gerard Jaouen
, Anne Vessiéres

Research output: Contribution to journal › Article › peer-review

Abstract

We report herein the labeling of 17α-ethynyl-17β-estradiol with a “Co₃(CO)₉” fragment. The cluster exhibits fully reversible electrochemical behavior and is assayed by means of the square-wave voltammetric technique. During the condensation of metallocarbonyl fragments around the organic chain, elimination of the 17β-OH group in the original molecule occurs, affording Co₃(CO)₉(dehydroxyethynylestradiol). This modification causes an important decrease of relative binding affinity for the receptors. However, the cluster can still be used for immunoassay of estradiol, since its cross reactivity for specific antibodies is high.

Original language	English
Pages (from-to)	3110-3114
Number of pages	5
Journal	Organometallics
Volume	13
Issue number	8
DOIs	https://doi.org/10.1021/om00020a027
Publication status	Published - 1 Aug 1994
Externally published	Yes

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title = "Estrogen Derivatives of Transition-Metal Complexes for Analytical Detection Enhancement",

abstract = "We report herein the labeling of 17α-ethynyl-17β-estradiol with a “Co3(CO)9” fragment. The cluster exhibits fully reversible electrochemical behavior and is assayed by means of the square-wave voltammetric technique. During the condensation of metallocarbonyl fragments around the organic chain, elimination of the 17β-OH group in the original molecule occurs, affording Co3(CO)9(dehydroxyethynylestradiol). This modification causes an important decrease of relative binding affinity for the receptors. However, the cluster can still be used for immunoassay of estradiol, since its cross reactivity for specific antibodies is high.",

author = "Domenico Osella and Olimpia Gambino and Carlo Nervi and Edison Stein and Gerard Jaouen and Anne Vessi{\'e}res",

year = "1994",

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doi = "10.1021/om00020a027",

language = "English",

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TY - JOUR

T1 - Estrogen Derivatives of Transition-Metal Complexes for Analytical Detection Enhancement

AU - Osella, Domenico

AU - Gambino, Olimpia

AU - Nervi, Carlo

AU - Stein, Edison

AU - Jaouen, Gerard

AU - Vessiéres, Anne

PY - 1994/8/1

Y1 - 1994/8/1

N2 - We report herein the labeling of 17α-ethynyl-17β-estradiol with a “Co3(CO)9” fragment. The cluster exhibits fully reversible electrochemical behavior and is assayed by means of the square-wave voltammetric technique. During the condensation of metallocarbonyl fragments around the organic chain, elimination of the 17β-OH group in the original molecule occurs, affording Co3(CO)9(dehydroxyethynylestradiol). This modification causes an important decrease of relative binding affinity for the receptors. However, the cluster can still be used for immunoassay of estradiol, since its cross reactivity for specific antibodies is high.

AB - We report herein the labeling of 17α-ethynyl-17β-estradiol with a “Co3(CO)9” fragment. The cluster exhibits fully reversible electrochemical behavior and is assayed by means of the square-wave voltammetric technique. During the condensation of metallocarbonyl fragments around the organic chain, elimination of the 17β-OH group in the original molecule occurs, affording Co3(CO)9(dehydroxyethynylestradiol). This modification causes an important decrease of relative binding affinity for the receptors. However, the cluster can still be used for immunoassay of estradiol, since its cross reactivity for specific antibodies is high.

UR - https://www.scopus.com/pages/publications/0000954341

U2 - 10.1021/om00020a027

DO - 10.1021/om00020a027

M3 - Article

SN - 0276-7333

VL - 13

SP - 3110

EP - 3114

JO - Organometallics

JF - Organometallics

IS - 8

ER -

Estrogen Derivatives of Transition-Metal Complexes for Analytical Detection Enhancement

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