Estradiols Modified by Metal Carbonyl Clusters as Suicide Substrates for the Study of Receptor Proteins: Application to the Estradiol Receptor

Anne Vessières; Siden Top; Colette Vaillant; Domenico Osella; Jean‐Paul ‐P Mornon; Gérard Jaouen

doi:10.1002/anie.199207531

Estradiols Modified by Metal Carbonyl Clusters as Suicide Substrates for the Study of Receptor Proteins: Application to the Estradiol Receptor

Anne Vessières
, Siden Top
, Colette Vaillant
, Domenico Osella
, Jean‐Paul ‐P Mornon
, Gérard Jaouen

Research output: Contribution to journal › Article › peer-review

Abstract

Derivatizing biomolecules with transition‐metal fragments can be a useful approach to some biochemical problems, for example in labeling hormone receptors. The estradiol derivatives 1–4 deactivate the estradiol receptor to varying degrees, allowing conclusions to be drawn concerning the chemical environment of the binding site. (Figure Presented.)

Original language	English
Pages (from-to)	753-755
Number of pages	3
Journal	Angewandte Chemie - International Edition
Volume	31
Issue number	6
DOIs	https://doi.org/10.1002/anie.199207531
Publication status	Published - Jun 1992
Externally published	Yes

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

Access to Document

10.1002/anie.199207531

Cite this

@article{6c100e57447f4b27b7bd8a2e4ae26016,

title = "Estradiols Modified by Metal Carbonyl Clusters as Suicide Substrates for the Study of Receptor Proteins: Application to the Estradiol Receptor",

abstract = "Derivatizing biomolecules with transition‐metal fragments can be a useful approach to some biochemical problems, for example in labeling hormone receptors. The estradiol derivatives 1{\textendash}4 deactivate the estradiol receptor to varying degrees, allowing conclusions to be drawn concerning the chemical environment of the binding site. (Figure Presented.)",

author = "Anne Vessi{\`e}res and Siden Top and Colette Vaillant and Domenico Osella and Mornon, \{Jean‐Paul ‐P\} and G{\'e}rard Jaouen",

year = "1992",

month = jun,

doi = "10.1002/anie.199207531",

language = "English",

volume = "31",

pages = "753--755",

journal = "Angewandte Chemie - International Edition",

issn = "0570-0833",

publisher = "John Wiley and Sons Inc.",

number = "6",

}

TY - JOUR

T1 - Estradiols Modified by Metal Carbonyl Clusters as Suicide Substrates for the Study of Receptor Proteins

T2 - Application to the Estradiol Receptor

AU - Vessières, Anne

AU - Top, Siden

AU - Vaillant, Colette

AU - Osella, Domenico

AU - Mornon, Jean‐Paul ‐P

AU - Jaouen, Gérard

PY - 1992/6

Y1 - 1992/6

N2 - Derivatizing biomolecules with transition‐metal fragments can be a useful approach to some biochemical problems, for example in labeling hormone receptors. The estradiol derivatives 1–4 deactivate the estradiol receptor to varying degrees, allowing conclusions to be drawn concerning the chemical environment of the binding site. (Figure Presented.)

AB - Derivatizing biomolecules with transition‐metal fragments can be a useful approach to some biochemical problems, for example in labeling hormone receptors. The estradiol derivatives 1–4 deactivate the estradiol receptor to varying degrees, allowing conclusions to be drawn concerning the chemical environment of the binding site. (Figure Presented.)

UR - https://www.scopus.com/pages/publications/33748242024

U2 - 10.1002/anie.199207531

DO - 10.1002/anie.199207531

M3 - Article

SN - 0570-0833

VL - 31

SP - 753

EP - 755

JO - Angewandte Chemie - International Edition

JF - Angewandte Chemie - International Edition

IS - 6

ER -

Estradiols Modified by Metal Carbonyl Clusters as Suicide Substrates for the Study of Receptor Proteins: Application to the Estradiol Receptor

Abstract

UN SDGs

Access to Document

Other files and links

Fingerprint

Cite this