A novel trinuclear platinum complex overcomes cisplatin resistance an osteosarcoma cell system

Keyphrases

• Platinum Complexes 100%
• Cell Systems 100%
• Cisplatin Resistance 100%
• Trinuclear 100%
• Osteosarcoma Cells 100%
• Cisplatin 80%
• DNA Lesions 80%
• Platinum Compounds 40%
• Multinuclear 40%
• Mismatch Repair 40%
• Cross-link Formation 40%
• Cytotoxicity 20%
• Molecular Size 20%
• Cellular Basis 20%
• U2OS Cells 20%
• Mononuclear Complexes 20%
• DNA Mismatch Repair Protein 20%
• PMS2 20%
• Drug-induced 20%
• Platinum Drugs 20%
• Microsatellite Instability-high (MSI-H) 20%
• DNA Interaction 20%
• Cell Resistance 20%
• DNA Platination 20%
• Cytotoxic Activity 20%
• Cellular Response 20%
• Cross-resistance 20%
• DNA Repair Pathways 20%
• HCT116 20%
• Reduced Expression 20%
• Drug-resistant Tumor 20%
• Human Osteosarcoma Cell Line 20%
• Intrastrand Cross-link 20%
• Resistant Phenotypes 20%
• Antitumor Efficacy 20%
• Drug-likeness 20%
• Drug Removal 20%
• Cellular Alterations 20%
• Monoadducts 20%
• Charge Size 20%
• Cisplatin Accumulation 20%

Immunology and Microbiology

• DNA Damage 100%
• Osteosarcoma Cell 100%
• Cross Linking 75%
• Mismatch Repair 50%
• Mismatch DNA Repair 25%
• Cytotoxicity 25%
• Microsatellite Instability 25%
• DNA Repair 25%
• Cross-Resistance 25%
• Molecular Size 25%
• Osteosarcoma Cell Line 25%
• In Vitro 25%

Biochemistry, Genetics and Molecular Biology

• Cisplatin 100%
• DNA Damage 40%
• DNA Mismatch Repair 30%
• Cross-Link 30%
• Isocitrate Lyase 20%
• Cytotoxicity 10%
• DNA Repair 10%
• Cross Resistance 10%
• Molecular Size 10%
• Microsatellite Instability 10%
• PMS2 10%