Epilepsy and bipolar disorders

Marco Mula, Antonella Ester Marotta, Francesco Monaco

Research output: Contribution to journalReview articlepeer-review

Abstract

Although mood disorders represent a frequent psychiatric comorbidity among patients with epilepsy, data regarding bipolar disorders are still limited. However, these two conditions apparently share a number of biochemical and pathophysiological underpinnings, such as the kindling phenomenon, changes in neurotransmitters and modifications in voltage-opened ion channels and second messenger systems. Moreover, epilepsy and bipolar disorders are both episodic conditions with a time course of illness that can become chronic. Recent data suggest that mood instability is actually frequent among patients with epilepsy but is phenomenologically different from that described in bipolar disorder. The present paper reviews available evidence regarding such an intriguing comorbidity in order to discuss valuable clinical issues and to suggest novel therapeutic strategies.

Original languageEnglish
Pages (from-to)13-23
Number of pages11
JournalExpert Review of Neurotherapeutics
Volume10
Issue number1
DOIs
Publication statusPublished - Jan 2010
Externally publishedYes

Keywords

  • Antidepressants
  • Antiepileptics
  • Antipsychotics
  • Bipolar disorder
  • Depression
  • Epilepsy
  • Lithium
  • Mania
  • Seizure

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