EP1572: A novel peptido-mimetic GH secretagogue with potent and selective GH-releasing activity in man

F. Broglio; F. Boutignon; A. Benso; C. Gottero; F. Prodam; E. Arvat; C. Ghè; F. Catapano; A. Torsello; V. Locatelli; G. Muccioli; D. Boeglin; V. Guerlavais; J. A. Fehrentz; J. Martinez; Ezio Ghigo; R. Deghenghi

doi:10.1007/BF03345096

EP1572: A novel peptido-mimetic GH secretagogue with potent and selective GH-releasing activity in man

F. Broglio, F. Boutignon, A. Benso, C. Gottero, F. Prodam, E. Arvat, C. Ghè, F. Catapano, A. Torsello, V. Locatelli, G. Muccioli, D. Boeglin, V. Guerlavais, J. A. Fehrentz, J. Martinez, Ezio Ghigo, R. Deghenghi

Research output: Contribution to journal › Article › peer-review

Abstract

EP1572 (JMV1843 [Aib-DTrp-DgTrp-CHO]) is a new peptido-mimetic GH secretagogue (GHS) showing binding potency to the GHS-receptor in animal and human tissues similar to that of ghrelin and peptidyl GHS. EP1572 induces marked GH increase after sc administration in neonatal rats. Preliminary data in 2 normal young men show that: 1) acute iv EP1572 administration (1.0 μg/kg) induces strong and selective increase of GH levels; 2) single oral EP1572 administration strongly and reproducibly increases GH levels even after a dose as low as 0.06 mg/kg. Thus, EP1572 is a new peptido-mimetic GHS with potent and selective GH-releasing activity.

Original language	English
Pages (from-to)	RC26-RC28
Journal	Journal of Endocrinological Investigation
Volume	25
Issue number	8
DOIs	https://doi.org/10.1007/BF03345096
Publication status	Published - Sept 2002
Externally published	Yes

Keywords

GH
Ghrelin receptors
Humans
Oral administration
Synthetic GH secretagogues

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1007/BF03345096

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Broglio, F., Boutignon, F., Benso, A., Gottero, C., Prodam, F., Arvat, E., Ghè, C., Catapano, F., Torsello, A., Locatelli, V., Muccioli, G., Boeglin, D., Guerlavais, V., Fehrentz, J. A., Martinez, J., Ghigo, E., & Deghenghi, R. (2002). EP1572: A novel peptido-mimetic GH secretagogue with potent and selective GH-releasing activity in man. Journal of Endocrinological Investigation, 25(8), RC26-RC28. https://doi.org/10.1007/BF03345096

@article{68d7ce33388f4569aa389373b8d7dffe,

title = "EP1572: A novel peptido-mimetic GH secretagogue with potent and selective GH-releasing activity in man",

abstract = "EP1572 (JMV1843 [Aib-DTrp-DgTrp-CHO]) is a new peptido-mimetic GH secretagogue (GHS) showing binding potency to the GHS-receptor in animal and human tissues similar to that of ghrelin and peptidyl GHS. EP1572 induces marked GH increase after sc administration in neonatal rats. Preliminary data in 2 normal young men show that: 1) acute iv EP1572 administration (1.0 μg/kg) induces strong and selective increase of GH levels; 2) single oral EP1572 administration strongly and reproducibly increases GH levels even after a dose as low as 0.06 mg/kg. Thus, EP1572 is a new peptido-mimetic GHS with potent and selective GH-releasing activity.",

keywords = "GH, Ghrelin receptors, Humans, Oral administration, Synthetic GH secretagogues",

author = "F. Broglio and F. Boutignon and A. Benso and C. Gottero and F. Prodam and E. Arvat and C. Gh{\`e} and F. Catapano and A. Torsello and V. Locatelli and G. Muccioli and D. Boeglin and V. Guerlavais and Fehrentz, {J. A.} and J. Martinez and Ezio Ghigo and R. Deghenghi",

year = "2002",

month = sep,

doi = "10.1007/BF03345096",

language = "English",

volume = "25",

pages = "RC26--RC28",

journal = "Journal of Endocrinological Investigation",

issn = "0391-4097",

publisher = "Springer Science and Business Media Deutschland GmbH",

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}

Broglio, F, Boutignon, F, Benso, A, Gottero, C, Prodam, F, Arvat, E, Ghè, C, Catapano, F, Torsello, A, Locatelli, V, Muccioli, G, Boeglin, D, Guerlavais, V, Fehrentz, JA, Martinez, J, Ghigo, E & Deghenghi, R 2002, 'EP1572: A novel peptido-mimetic GH secretagogue with potent and selective GH-releasing activity in man', Journal of Endocrinological Investigation, vol. 25, no. 8, pp. RC26-RC28. https://doi.org/10.1007/BF03345096

TY - JOUR

T1 - EP1572

T2 - A novel peptido-mimetic GH secretagogue with potent and selective GH-releasing activity in man

AU - Broglio, F.

AU - Boutignon, F.

AU - Benso, A.

AU - Gottero, C.

AU - Prodam, F.

AU - Arvat, E.

AU - Ghè, C.

AU - Catapano, F.

AU - Torsello, A.

AU - Locatelli, V.

AU - Muccioli, G.

AU - Boeglin, D.

AU - Guerlavais, V.

AU - Fehrentz, J. A.

AU - Martinez, J.

AU - Ghigo, Ezio

AU - Deghenghi, R.

PY - 2002/9

Y1 - 2002/9

N2 - EP1572 (JMV1843 [Aib-DTrp-DgTrp-CHO]) is a new peptido-mimetic GH secretagogue (GHS) showing binding potency to the GHS-receptor in animal and human tissues similar to that of ghrelin and peptidyl GHS. EP1572 induces marked GH increase after sc administration in neonatal rats. Preliminary data in 2 normal young men show that: 1) acute iv EP1572 administration (1.0 μg/kg) induces strong and selective increase of GH levels; 2) single oral EP1572 administration strongly and reproducibly increases GH levels even after a dose as low as 0.06 mg/kg. Thus, EP1572 is a new peptido-mimetic GHS with potent and selective GH-releasing activity.

AB - EP1572 (JMV1843 [Aib-DTrp-DgTrp-CHO]) is a new peptido-mimetic GH secretagogue (GHS) showing binding potency to the GHS-receptor in animal and human tissues similar to that of ghrelin and peptidyl GHS. EP1572 induces marked GH increase after sc administration in neonatal rats. Preliminary data in 2 normal young men show that: 1) acute iv EP1572 administration (1.0 μg/kg) induces strong and selective increase of GH levels; 2) single oral EP1572 administration strongly and reproducibly increases GH levels even after a dose as low as 0.06 mg/kg. Thus, EP1572 is a new peptido-mimetic GHS with potent and selective GH-releasing activity.

KW - GH

KW - Ghrelin receptors

KW - Humans

KW - Oral administration

KW - Synthetic GH secretagogues

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U2 - 10.1007/BF03345096

DO - 10.1007/BF03345096

M3 - Article

SN - 0391-4097

VL - 25

SP - RC26-RC28

JO - Journal of Endocrinological Investigation

JF - Journal of Endocrinological Investigation

IS - 8

ER -

EP1572: A novel peptido-mimetic GH secretagogue with potent and selective GH-releasing activity in man

Abstract

Keywords

UN SDGs

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