Eosinophilic inflammation of chronic rhinosinusitis with nasal polyps is related to OX40 ligand expression

Monica Boita; Massimiliano Garzaro; Luca Raimondo; Giuseppe Riva; Jasenka Mazibrada; Giancarlo Pecorari; Caterina Bucca; Graziella Bellone; Barbara Vizio; Enrico Heffler; Fabio Luigi Ricciardolo; Giovanni Rolla

doi:10.1177/1753425914523460

Eosinophilic inflammation of chronic rhinosinusitis with nasal polyps is related to OX40 ligand expression

Monica Boita, Massimiliano Garzaro, Luca Raimondo, Giuseppe Riva, Jasenka Mazibrada, Giancarlo Pecorari, Caterina Bucca, Graziella Bellone, Barbara Vizio, Enrico Heffler, Fabio Luigi Ricciardolo, Giovanni Rolla

Research output: Contribution to journal › Article › peer-review

Abstract

The aims of this study were to investigate OX40 ligand expression in sinus tissue from patients with nasal polyposis compared with patients with chronic rhinosinusitis without nasal polyps (NPs), and to determine if OX40 ligand expression is related to eosinophilic sinus infiltration. Twenty patients with chronic rhinosinusitis (11 with and nine without NPs) and seven controls were enrolled in the study. The mRNA expression of OX40 ligand and thymic stromal lymphopoietin and its receptor were analyzed. The immunoreactivity score for OX40 ligand and the eosinophil count were obtained. The mRNA expression and immunoreactivity score of OX40 ligand were higher in patients with nasal polyposis than in patients without NPs, as well as healthy controls. The mRNA expression of thymic stromal lymphopoietin and its receptor was significantly higher in nasal polyposis than in the control, but not significantly higher than in chronic rhinosinusitis without NPs. A correlation between the number of OX40 ligand-positive cells and the number of eosinophils in sinus biopsies was found only in patients with nasal polyposis. In conclusion, the thymic stromal lymphopoietin/OX40 ligand axis is up-regulated in nasal polyposis and is related to the intensity of eosinophilic inflammation.

Original language	English
Pages (from-to)	167-174
Number of pages	8
Journal	Innate Immunity
Volume	21
Issue number	2
DOIs	https://doi.org/10.1177/1753425914523460
Publication status	Published - 8 Feb 2015
Externally published	Yes

Keywords

Chronic rhinosinusitis
OX40
TSLP
eosinophils
nasal polyps

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1177/1753425914523460

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title = "Eosinophilic inflammation of chronic rhinosinusitis with nasal polyps is related to OX40 ligand expression",

abstract = "The aims of this study were to investigate OX40 ligand expression in sinus tissue from patients with nasal polyposis compared with patients with chronic rhinosinusitis without nasal polyps (NPs), and to determine if OX40 ligand expression is related to eosinophilic sinus infiltration. Twenty patients with chronic rhinosinusitis (11 with and nine without NPs) and seven controls were enrolled in the study. The mRNA expression of OX40 ligand and thymic stromal lymphopoietin and its receptor were analyzed. The immunoreactivity score for OX40 ligand and the eosinophil count were obtained. The mRNA expression and immunoreactivity score of OX40 ligand were higher in patients with nasal polyposis than in patients without NPs, as well as healthy controls. The mRNA expression of thymic stromal lymphopoietin and its receptor was significantly higher in nasal polyposis than in the control, but not significantly higher than in chronic rhinosinusitis without NPs. A correlation between the number of OX40 ligand-positive cells and the number of eosinophils in sinus biopsies was found only in patients with nasal polyposis. In conclusion, the thymic stromal lymphopoietin/OX40 ligand axis is up-regulated in nasal polyposis and is related to the intensity of eosinophilic inflammation.",

keywords = "Chronic rhinosinusitis, OX40, TSLP, eosinophils, nasal polyps",

author = "Monica Boita and Massimiliano Garzaro and Luca Raimondo and Giuseppe Riva and Jasenka Mazibrada and Giancarlo Pecorari and Caterina Bucca and Graziella Bellone and Barbara Vizio and Enrico Heffler and Ricciardolo, {Fabio Luigi} and Giovanni Rolla",

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T1 - Eosinophilic inflammation of chronic rhinosinusitis with nasal polyps is related to OX40 ligand expression

AU - Boita, Monica

AU - Garzaro, Massimiliano

AU - Raimondo, Luca

AU - Riva, Giuseppe

AU - Mazibrada, Jasenka

AU - Pecorari, Giancarlo

AU - Bucca, Caterina

AU - Bellone, Graziella

AU - Vizio, Barbara

AU - Heffler, Enrico

AU - Ricciardolo, Fabio Luigi

AU - Rolla, Giovanni

PY - 2015/2/8

Y1 - 2015/2/8

N2 - The aims of this study were to investigate OX40 ligand expression in sinus tissue from patients with nasal polyposis compared with patients with chronic rhinosinusitis without nasal polyps (NPs), and to determine if OX40 ligand expression is related to eosinophilic sinus infiltration. Twenty patients with chronic rhinosinusitis (11 with and nine without NPs) and seven controls were enrolled in the study. The mRNA expression of OX40 ligand and thymic stromal lymphopoietin and its receptor were analyzed. The immunoreactivity score for OX40 ligand and the eosinophil count were obtained. The mRNA expression and immunoreactivity score of OX40 ligand were higher in patients with nasal polyposis than in patients without NPs, as well as healthy controls. The mRNA expression of thymic stromal lymphopoietin and its receptor was significantly higher in nasal polyposis than in the control, but not significantly higher than in chronic rhinosinusitis without NPs. A correlation between the number of OX40 ligand-positive cells and the number of eosinophils in sinus biopsies was found only in patients with nasal polyposis. In conclusion, the thymic stromal lymphopoietin/OX40 ligand axis is up-regulated in nasal polyposis and is related to the intensity of eosinophilic inflammation.

AB - The aims of this study were to investigate OX40 ligand expression in sinus tissue from patients with nasal polyposis compared with patients with chronic rhinosinusitis without nasal polyps (NPs), and to determine if OX40 ligand expression is related to eosinophilic sinus infiltration. Twenty patients with chronic rhinosinusitis (11 with and nine without NPs) and seven controls were enrolled in the study. The mRNA expression of OX40 ligand and thymic stromal lymphopoietin and its receptor were analyzed. The immunoreactivity score for OX40 ligand and the eosinophil count were obtained. The mRNA expression and immunoreactivity score of OX40 ligand were higher in patients with nasal polyposis than in patients without NPs, as well as healthy controls. The mRNA expression of thymic stromal lymphopoietin and its receptor was significantly higher in nasal polyposis than in the control, but not significantly higher than in chronic rhinosinusitis without NPs. A correlation between the number of OX40 ligand-positive cells and the number of eosinophils in sinus biopsies was found only in patients with nasal polyposis. In conclusion, the thymic stromal lymphopoietin/OX40 ligand axis is up-regulated in nasal polyposis and is related to the intensity of eosinophilic inflammation.

KW - Chronic rhinosinusitis

KW - OX40

KW - TSLP

KW - eosinophils

KW - nasal polyps

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DO - 10.1177/1753425914523460

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JO - Innate Immunity

JF - Innate Immunity

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Eosinophilic inflammation of chronic rhinosinusitis with nasal polyps is related to OX40 ligand expression

Abstract

Keywords

UN SDGs

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