Efficient synthesis of α-ketoamides via 2-acyl-5-aminooxazoles by reacting acyl chlorides and α-isocyanoacetamides

Riccardo Mossetti; Tracey Pirall; Gian Cesare Tron; Jieping Zhu

doi:10.1021/ol902894p

Efficient synthesis of α-ketoamides via 2-acyl-5-aminooxazoles by reacting acyl chlorides and α-isocyanoacetamides

Riccardo Mossetti
, Tracey Pirall
, Gian Cesare Tron
, Jieping Zhu

Department of Pharmaceutical Sciences

Research output: Contribution to journal › Article › peer-review

Abstract

"Chemical equation presented" Acyl chlorides and α-isocyanoacetamides undergo an efficient reaction in dichloromethane in the presence of triethylamine to give 2-acyl5-aminooxazoles. Subsequent acid hydrolysis of the 5-aminooxazole moiety leads to α-ketoamides in good overall yields.

Original language	English
Pages (from-to)	820-823
Number of pages	4
Journal	Organic Letters
Volume	12
Issue number	4
DOIs	https://doi.org/10.1021/ol902894p
Publication status	Published - 19 Feb 2010

Access to Document

10.1021/ol902894p

Cite this

@article{cad5d76c0113435e9e3efc1add82555a,

title = "Efficient synthesis of α-ketoamides via 2-acyl-5-aminooxazoles by reacting acyl chlorides and α-isocyanoacetamides",

abstract = "{"}Chemical equation presented{"} Acyl chlorides and α-isocyanoacetamides undergo an efficient reaction in dichloromethane in the presence of triethylamine to give 2-acyl5-aminooxazoles. Subsequent acid hydrolysis of the 5-aminooxazole moiety leads to α-ketoamides in good overall yields.",

author = "Riccardo Mossetti and Tracey Pirall and Tron, \{Gian Cesare\} and Jieping Zhu",

year = "2010",

month = feb,

day = "19",

doi = "10.1021/ol902894p",

language = "English",

volume = "12",

pages = "820--823",

journal = "Organic Letters",

issn = "1523-7060",

publisher = "American Chemical Society",

number = "4",

}

TY - JOUR

T1 - Efficient synthesis of α-ketoamides via 2-acyl-5-aminooxazoles by reacting acyl chlorides and α-isocyanoacetamides

AU - Mossetti, Riccardo

AU - Pirall, Tracey

AU - Tron, Gian Cesare

AU - Zhu, Jieping

PY - 2010/2/19

Y1 - 2010/2/19

N2 - "Chemical equation presented" Acyl chlorides and α-isocyanoacetamides undergo an efficient reaction in dichloromethane in the presence of triethylamine to give 2-acyl5-aminooxazoles. Subsequent acid hydrolysis of the 5-aminooxazole moiety leads to α-ketoamides in good overall yields.

AB - "Chemical equation presented" Acyl chlorides and α-isocyanoacetamides undergo an efficient reaction in dichloromethane in the presence of triethylamine to give 2-acyl5-aminooxazoles. Subsequent acid hydrolysis of the 5-aminooxazole moiety leads to α-ketoamides in good overall yields.

UR - https://www.scopus.com/pages/publications/76849113146

U2 - 10.1021/ol902894p

DO - 10.1021/ol902894p

M3 - Article

SN - 1523-7060

VL - 12

SP - 820

EP - 823

JO - Organic Letters

JF - Organic Letters

IS - 4

ER -

Efficient synthesis of α-ketoamides via 2-acyl-5-aminooxazoles by reacting acyl chlorides and α-isocyanoacetamides

Abstract

Access to Document

Other files and links

Fingerprint

Cite this